Researchers report that whereas gene therapies in mice based on 3 longevity-associated genes, namely FGF21, ?Klotho, and sTGF?R2, ameliorated age-related diseases, including obesity, type II diabetes, heart failure, and renal failure, a single formulation combining 2 of the therapies was able to treat all 4 age-related disorders in mice, suggesting that combinations of gene therapies may help address the interconnectedness of distinct age-related diseases and extend human health-span, according to the authors.
Article #19-10073: "A single combination gene therapy treats multiple age-related diseases," by Noah Davidsohn et al.
MEDIA CONTACT: George M. Church, Harvard University, Boston, MA; tel: 617-432-1278; e-mail: gchurch@genetics.med.harvard.edu
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Proceedings of the National Academy of Sciences