Using an ultrahigh-throughput, microfluidic droplet-based platform to screen the oral microbiome of Siberian brown bears ( Ursus arctos collaris ), researchers identified strains of Bacillus pumilus producing the antibiotic amicoumacin A, which kills the pathogenic bacterium Staphylococcus aureus ; the droplet-based approach also helped uncover a mechanism by which Bacillus resists the antibiotic, suggesting that the platform could be used to discover novel antibiotics and screen for antibiotic resistance, according to a study.
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Article #18-11250: "Ultrahigh-throughput functional profiling of microbiota communities" by Stanislav S. Terekhov et al.
MEDIA CONTACT: Alexander Gabibov, Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, RUSSIA; e-mail: < gabibov@ibch.ru >
Proceedings of the National Academy of Sciences