Articles tagged with Microbiota
Researchers at LMU identified a specific bacterial signal that shapes immune response to stroke, worsened brain injury in mice. Indole-producing bacteria acted on AHR receptor in dendritic cells, promoting protective T cells and reducing damage. The study raises potential for targeting gut microbiota to improve stroke outcome.
A new study found that consuming sweets while taking antibiotics amplifies the harm done to the gut microbiome, reducing its diversity and making it more vulnerable to disease. The research tracked 9,419 meals and found that every 100 grams of sugar consumed resulted in a 21% reduction in alpha diversity.
Researchers have identified a unique 'bacterial signature' that flags individuals at risk of type 2 diabetes, even if their blood sugar levels are normal. The study analyzed data from over 200,000 adults and found that changes in the gut microbiome can be detected before the onset of diabetes.
Mizzou researchers have developed an AI tool called MeLSI that can identify specific microbes driving key biological changes in the gut microbiome, which may indicate early warning signs of disease. The tool has shown promising results in detecting meaningful patterns in microbiome data that conventional methods miss.
Researchers found that frogs' natural skin bacteria can help them fight disease and improve survival chances. The study identified disease-inhibiting bacteria that helped certain frogs survive infection.
Scientists have engineered a nonpathogenic E. coli bacterium to carry a phage that specifically targets salmonella, resulting in a protective lining against infections. This breakthrough could lead to the development of new treatments for other diseases, particularly those with high global disease burdens.
A new study identifies bacteria-infecting viruses and antibiotic resistance genes as harbingers of necrotizing enterocolitis in premature infants. The findings suggest that these biomarkers can predict the disease up to eight days before clinical symptoms appear, offering clinicians a window of opportunity to intervene.
Researchers discovered how E. coli bacteria can quickly adapt to attach to human cells when they lose one of their main attachment mechanisms, and found that this process can lead to stronger attachment and more effective infection. The findings suggest a possible target for future treatments that could prevent bacterial attachment and...
A new UCLA study has found a connection between brain aging and gut biology, suggesting that people's brains may be aging decades before symptoms appear. The study, published in eBioMedicine, analyzed brain scans and stool samples to identify a link between brain communication patterns, gut bacteria, and brain aging.
A study found that probiotic supplement use increased 287% among adults and 786% among young people, while fiber intake remained unchanged, between 2009 and 2023. Probiotic users consumed more high-microbial foods and fiber content than non-users, but these beneficial diet habits may be decreasing due to supplement use.
Researchers discovered a bacterium in urine that can convert DHEA into testosterone, shedding light on a previously unknown microbial route to a hormone central to prostate biology. This finding raises new questions about the potential role of microorganisms near the prostate in shaping its chemical environment.
Researchers at the University of Gothenburg identified a link between specific gut bacteria activities and primary sclerosing cholangitis, a rare chronic liver disease. Elevated levels of the metabolite ImP, formed by gut bacteria breakdown, can predict poorer survival outcomes and induce liver inflammation in PSC patients.
The International Society of Microbiota has partnered with the Global Grants for Gut Health program to expand funding opportunities for Japanese early-career researchers. The new partnership will bring $100,000 in funding to Tokyo, highlighting the global significance of microbiome research in Japan.
Researchers found altered gene expression in wharf roach guts after consuming expanded polystyrene, but no significant impact on lifespan. The gut microbiome showed little change, but rare microbes were detected in EPS-fed specimens. This highlights the need to manage EPS waste carefully and prioritize coastal cleanup efforts.
The new center aims to better understand diseases and treatment response by combining human genetics and microbiome research with AI. Researchers will investigate how genetic variation and the gut microbiome jointly shape disease progression and treatment response.
Researchers found that corisin, a bacterial protein fragment, drives tissue fibrosis by disrupting the cell's quality-control system. Antibody treatment can help by blocking corisin, demonstrating its biologically active and causally supported role in disease.
A new study published in Science Advances found that bacteria and fungi from Earth can survive for at least a week in shaded nooks and crannies around the lunar south pole. The study's findings highlight the need to better understand microbial persistence in extreme lunar environments, which is crucial for future space missions.
A three-year field study found that deeper straw incorporation reduced maize ear rot and mycotoxin contamination while improving soil health and microbial communities. The study suggests that optimizing straw management strategies could turn a familiar practice into a more effective tool for soil health and food safety.
A new study from the University of Copenhagen reveals that astronauts experience changes in their gut bacteria shortly after leaving Earth and gravity behind. The researchers found increased protein fermentation, which may contribute to constipation, and suggest potential interventions for future long-duration space missions.
Research at UT MD Anderson Cancer Center has identified biomarkers to identify patients with resectable NSCLC who benefit most from perioperative immunotherapy. The center also found that the composition of donor cord blood may influence CAR NK cell therapy outcomes.
Researchers found that upper and lower surfaces of oak leaves support different microbial communities, with the upper surface hosting stress-tolerant genera and the lower surface favoring sugar-fermenting taxa and insect-associated bacteria. The two sides show striking seasonal divergence in terms of diversity and abundance.
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
Hepatic encephalopathy recurrence can be reduced through education on precipitants correction and pharmacotherapy with lactulose and rifaximin. Nutritional support with protein-rich diets improves QOL and reduces episodes.
A novel treatment approach combining phage therapy and fecal microbiota transplantation has shown promise in treating recurring urinary tract infections. The study, published in Nature Microbiology, found that the treatment reduced UTI episodes and improved quality of life for patients.
Researchers at UC Davis identified a naturally occurring metabolite, 10-hydroxystearic acid (10-HSA), that repairs gut damage caused by HIV infection. Combining 10-HSA with standard antiretroviral therapy improved viral suppression and helped rebuild gut immune defenses in animal models of AIDS.
Researchers at Duke University have developed a method to systematically develop novel probiotic and prebiotic combinations to maintain gut health and treat gastrointestinal diseases. The approach uses machine learning and automation to explore complex interactions between microbes, nutritional sources, and the environment.
Researchers develop synthetic microbial communities to degrade persistent herbicides, improving degradation rates by 1.5-3 times compared to individual strains or natural attenuation. The approach promotes more complete mineralization of pollutants and resilience in complex soil environments.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers are studying foul-smelling substances to understand what attracts the New World screwworm, a flesh-eating parasite, to its favorite meal - open wounds. The goal is to develop better lures for trapping this serious threat to the livestock industry.
A UMaine-led research team has been awarded the inaugural DOE Genesis Mission to develop AI-powered models that simulate the impact of microbes on underground chemical reactions. The project aims to improve predictions in groundwater management, environmental remediation, and energy infrastructure planning.
A randomized clinical trial found that ingesting fecal microbes from healthy donors improved sleep efficiency and reduced wake after sleep onset in participants with chronic insomnia. Sleep quality scores also showed significant improvement over two months.
A new study argues that the microbiome-gut-brain axis has been predominantly studied in wealthy, industrialised nations, limiting scientific discovery. The authors call for greater international collaboration and investment in research infrastructure to uncover universal biological principles that can improve mental health worldwide.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A six-year study on drought's impact on soil microbial communities found decreased biodiversity and shifted ecological configurations. This decline affects nutrient cycling processes and broader ecosystem health.
A study by UNIFESP found that chronic xanthan gum consumption causes colon inflammation, alters gut microbiota, and leads to intestinal barrier integrity loss in rats. This supports previous observations of necrotizing enterocolitis in premature infants linked to xanthan gum use.
A new study published in Biochar shows that combining green manure with biochar can improve soil quality, support maize yield, and reduce dependence on nitrogen fertilizer. The research found that soil microbial diversity emerged as a central driver of improved soil quality.
The gut microbiome is recognized as a key driver of tumor initiation and progression, with microbial dysbiosis fueling malignancy or enhancing anti-tumor immunity. Microbiome science and cancer biology are converging to develop new strategies for prevention, diagnosis, and therapy.
Researchers at UT Health San Antonio found a link between the bacterium Faecalibacterium prausnitzii and systemic lupus erythematosus. Supplementation with this bacteria reduced markers of the disease in animal models, showing promise for treatment.
A study published in Frontiers in Cellular and Infection Microbiology found that healthy infant gut microbiomes are linked to reduced risk of malaria. Babies with beneficial microbes like Bifidobacterium were less likely to develop the disease. However, further research is needed to confirm this association.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers from Institute of Science Tokyo found that postbiotic foods can improve gum health in adults with mild gingivitis, reducing gum bleeding and inflammation. The study suggests a simple way to support oral health without altering oral care habits.
A pilot clinical trial found that adding probiotics to standard care reduced depressive and anxiety symptoms in older adults with moderate depression. However, probiotics did not confer clear additional gains in quality of life compared to a placebo.
Researchers found that areas with more vegetation in Taipei's metropolitan area had higher microbial richness and diversity. The Green View Index measures visible greenery from a pedestrian's perspective and correlates strongly with microbial richness.
Jacques Ravel has been recognized for his foundational contributions to understanding the human vaginal microbiome, its links to pregnancy outcomes and susceptibility to infection. His work also laid the groundwork for live biotherapeutics designed to shape the vaginal microbiome in ways that could improve pregnancy outcomes.
Researchers found that cohabiting individuals shared significantly more oral and gut strains than those living in different households. On average, cohabitors shared 19% of their gut microbiome and 26% of their oral microbiome strains with each other.
A study of 60 pregnant women found associations between maternal factors and microbiota-derived extracellular vesicle profiles in amniotic fluid. Maternal overweight and obesity were linked to lower proportions of certain bacterial groups.
Researchers found that eliminating sugar from a low-fat diet can lead to impaired glucose control, insulin resistance, and gut microbial imbalance. Balanced dietary carbohydrates are essential for supporting gut and immune homeostasis.
A study published in Cell Host & Microbe suggests that GLP-1 analogs may alleviate depression in mice by modulating the gut microbiome. The researchers found that a specific microbe strain, Lactobacillus delbrueckii, played a key role in this process.
Researchers found that people living in areas with more vegetation had a wider microbial variety in their noses, correlating with better mental health scores. Time spent outside was also associated with a healthy nasal microbiome and lower depressive scores.
Researchers investigated the interplay between host and gut microbiota in selenium metabolism, finding that gut microbiota transform selenium into metabolites influencing utilization, detoxification, and excretion. The study also revealed that Se intake affects bacterial diversity and that gut microbes produce unique selenometabolites.
Researchers developed a new method to raise germ-free zebrafish using gamma irradiation, enabling long-term studies of host-microbe interactions. This approach revealed significant differences between germ-free and intact zebrafish, suggesting conserved roles for microbiomes in immunity and metabolism across species.
A study published in PLOS One analyzed microbial communities in well-preserved and degraded bones from medieval cemeteries in Norway. The researchers found distinct microbial communities associated with different levels of degradation, suggesting that microbes play a role in bone preservation and decay.
A study by Harvard T.H. Chan School of Public Health found that gut microbiome alterations persist even after adenoma removal, increasing the risk of colorectal cancer. The researchers discovered that diet and physical activity were closely tied to CRC-associated gut microbes, suggesting lifestyle habits may contribute to sustained risk.
A new screening tool tests for microbial metabolites in urine to identify children at risk for autism, with 90% sensitivity and 100% specificity. The test may guide more targeted interventions, including approaches to restore a healthy gut microbiome.
A Tulane University study found that long-term antiretroviral treatments did not fully restore key immune functions to protect and repair the gut lining in nonhuman primates with SIV. The researchers discovered that diet-derived compounds from vegetables like broccoli and cabbage may support immune activity involved in gut repair.
Researchers found that the gut responds to protein deficiency by activating a fast neural circuit and a slower hormonal signal, which selectively changes dietary priorities. The study reveals a previously unknown gut-brain signaling system that rapidly alters feeding behavior in animals.
Researchers found that aerobic exercise counteracted oxidative stress and inflammation caused by nanoplastics in female zebrafish. Exercise also improved neuroendocrine health by altering gut microbe balances.
A new study found that lobster eggs host surprisingly diverse microbiomes that change as the embryos develop but remain stable under conditions simulating future environmental conditions. The findings challenge decades of assumptions about disease risks in the American lobster fishery.
Researchers tracked six NCAA Division I football players over a season and found that non-concussive head impacts correlated with changes to the gut microbiome. The study suggests that even sub-symptomatic head impacts might affect the gut microbiome, both in the immediate aftermath of injury and over a longer time course.