Articles tagged with Microbiota
Researchers found that an imbalanced gut microbiome escalates the production of metabolic byproducts, driving a feedback loop that worsens CKD. Blocking a single enzyme in the gut stopped this cycle, suggesting iNOS as a potential target for treatment.
Using azithromycin within one day triggers antibiotic resistance in the respiratory tract, according to a study published in Nature Microbiology. The researchers followed hospitalized COVID-19 patients and found that azithromycin changed the mix of microbes in the upper airway, leading to persistent changes for more than a week.
A high-fat diet allows bacteria to move from the gut to the brain in mice, according to a new study. Researchers found that a small number of bacteria translocated to the brain, likely via the vagus nerve, and that these bacteria were also detected in mouse models of Alzheimer's, Parkinson's, and autism.
A new study from Emory University finds that live bacteria from an imbalanced gut microbiome can enter the brain via the vagus nerve, potentially initiating neurological conditions. The study used mouse models and found that high-fat diets increased intestinal barrier permeability, allowing bacteria to reach the brain.
Researchers studied the Seychelles warbler's gut bacteria, finding that immune genes influence which microbes thrive, and that this relationship affects host health and survival. The study suggests a two-way relationship between immune genes and gut bacteria, with potential benefits for human health and disease prevention.
A new study found that voluntary exercise reshapes the gut microbiota, leading to changes in tryptophan metabolism and serotonin signaling. Exercise decreased the relative abundance of certain bacterial genera, shifting neuroactive signaling and lowering a key receptor in the memory center of the brain.
Research found that Roseburia inulinivorans is positively associated with muscle mass and strength in both young and older adults. The study suggests that R inulinivorans may play a causal role in muscle strength, with notable increases in forelimb grip strength and larger muscle fibre size in mice treated with the bacteria.
Researchers at King's College London discovered that certain genetic features of gut bacteria predict long-term survival after fecal transplants. These stable gene groups are linked to traits that help good bacteria compete and survive, and may be used as a source of future drugs.
Pituitary neuroendocrine tumors (PitNETs) are associated with cognitive decline, which may be linked to hormonal dysregulation and gut microbiota alterations. Surgical intervention improves cognitive function, suggesting a potential endocrine mechanism underlying cognitive dysfunction and recovery.
Research reveals complex interactions between soil microbes, viruses, and microplastics, influencing soil health and ecosystem recovery. Innovations such as phage-assisted microbial augmentation aim to enhance plastic degradation in soils.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
Researchers at Houston Methodist found that short-term antibiotic treatment significantly reduced neuroinflammation and neurodegeneration following traumatic brain injury by altering the gut microbiome. Beneficial bacteria Parasutterella excrementihominis and Lactobacillus johnsonii drove cell repair, while reducing harmful gut bacteria.
A global team of scientists, led by University of Houston microbiologist Madhan Tirumalai, has identified the critical role of biofilms in human space exploration. Biofilms could influence astronaut health, drug delivery and space agriculture, while also posing risks to astronaut health.
A growing body of research suggests that microplastics in soils can alter microbial genes controlling essential ecosystem functions, potentially affecting food production, climate processes, and environmental health. Microplastics also enhance the spread of antibiotic resistance genes in soil ecosystems.
A global atlas mapping two key gut bacteria has uncovered a treasure trove of bacterial strains adapted to the infant gut, not found in commercial probiotic products. The study reveals region-specific strains that have naturally evolved to thrive in a baby's microbiome, shaped by regional diets and environments.
A new study finds salcaprozate sodium may have adverse biological effects on the gut and beyond, including shifts in potentially harmful gut bacteria and elevated inflammatory markers. The research highlights an important gap in understanding the long-term impact of repeated SNAC exposure.
Researchers at UCSF and Wayne State University found that generative AI tools can perform orders of magnitude faster than human teams in analyzing health data. Junior researchers paired with AI generated viable prediction models in minutes, outperforming experienced programmers in hours or days.
A study by NYU researchers found that children with Crohn’s disease have a unique microbiome signature, characterized by more pro-inflammatory and less protective bacteria. This could lead to personalized treatments for pediatric Crohn’s disease.
Researchers focus on system-level resilience and long-term biological coordination to understand aging as a loss of coordination between biological systems. Studies show how mitochondrial signaling influences inflammation in senescence and microbiota–brain interactions shape aging trajectories.
Researchers developed wearable devices that track hydrogen levels in flatus to better understand gut microbial metabolism. The Human Flatus Atlas project aims to establish normal ranges for flatulence production, helping to identify excessive gas complaints and inform dietary interventions.
A global study found that a group of bacteria, CAG-170, consistently appeared in high numbers in the gut microbiomes of healthy individuals. This species has the capacity to produce Vitamin B12 and break down carbohydrates, suggesting it plays a crucial role in maintaining human health.
Blautia luti produces formic acid as an electron taxi, bypassing the energetically costly production of hydrogen. The bacterium detoxifies formic acid via a special metabolic pathway, linked to sugar breakdown and acetic acid production.
Researchers at the University of Maryland School of Medicine discovered 25 distinct vaginal microbiome types, challenging the long-standing view of a simplified
A study published in Microbiome found that gut microbiome-derived butyrate activates immune cells to enhance vaccine efficacy by promoting T follicular helper (Tfh) cell activity and mucosal antibody production. This discovery highlights the crucial role of gut environment regulation in controlling infections and enhancing vaccine resp...
The vaginal microbiota is influenced by competition for specific nutritional resources, affecting health outcomes. A resource-based model identified key ecological mechanisms underlying microbiota composition and potential bacterial vaginosis interventions.
Researchers at Helmholtz Munich discovered that gut bacteria can directly deliver proteins into human cells, shaping immune responses. This new mechanism may help explain how changes in gut bacteria contribute to inflammatory diseases like Crohn's disease.
Researchers found that six species exhibited little to no evidence of phylosymbiosis, while five closely related bovids showed patterns consistent with the concept. Drier environments may reveal phylosymbiosis due to reduced microbial diversity.
Researchers at UC Riverside find that faulty gene PTPN2 increases susceptibility to harmful bacteria like AIEC, leading to gut inflammation and IBD. The studies suggest that restoring PTPN2 function or using medications like JAK inhibitors may help control harmful bacterial growth.
A new study reveals that gut microbiota directly affects intestinal stem cell function, leading to impaired regeneration after injury. Restoring a more youthful microbiota can reverse the age-related decline in ISC activity.
Researchers found that hot spring bathing in Japanese macaques subtly reshapes their relationships with parasites and gut microbes. The study suggests that behavior can shape the animal holobiont and act as an important driver of animal health.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
Researchers found that vermicomposting reduces antibiotic resistance genes by 70-95% and mobile genetic elements by up to 68%. The process uses earthworms to transform raw manure into a stable, high-value fertilizer.
A recent study reveals that the specific genetic identity of rice plants determines which microbes they host and how those microbes function. The research found that differences among rice genotypes strongly shape microbial communities in both soil and on leaf surfaces, influencing nutrient cycling, plant health, and soil carbon storage.
A new international study found significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a condition that affects the digestive system. The study reveals a loss of beneficial anaerobic bacteria and an increase in oxygen-tolerant bacteria, which may trigger inflammation.
A new international study discovers that combining biochar with straw can reduce carbon emissions, boost soil health, and encourage microbes to work together. The research bridges Moscow and Guangzhou, delivering one of the clearest pictures yet of how organic amendments shape the hidden world beneath our feet.
A new study found that genetic communities in rats are shaped by their social partners' genes. Researchers identified three gene-microbe associations, including one linked to bacteria that feed on sugar molecules added to mucus.
Researchers identified a specific type of gut bacteria, Turicibacter, that promotes metabolic health and reduces weight gain in mice. The bacterium produces fatty molecules that are absorbed by the small intestine, improving ceramide levels and preventing excessive weight gain.
New research reveals biochar's impact on autotrophic soil microbes that fix carbon dioxide through the Calvin cycle. In paddy soils, these microbes are active capturing carbon dioxide, while in upland soils, microbial biomass and labile carbon pools play a larger role.
Researchers have developed a new test that uses microbes to determine the age of termite droppings, allowing for rapid on-site infestation assessments. The study found that the amount of DNA from E. coli bacteria in the pellets decreases significantly over time, with a nearly 190-fold drop by the 12-month mark.
Researchers found that stool metabolites accurately reflect dietary intake and gut microbiome responses, identifying key food groups and associated compounds. The study suggests a powerful indicator of future heart disease risk, potentially offering more insight than diet scores alone.
Research reveals that Methanogenic archaea, particularly M. smithii, play a crucial role in postnatal growth retardation by depleting β-hydroxybutyrate levels and inducing liver inflammation. Transplanting fecal microbiome from PGR piglets to mice confirms the same phenotypes.
A new study published in Gut Microbes reveals that married individuals with higher perceived emotional support have a lower body mass index and fewer food addiction behaviors. The study found that oxytocin pathways linking the brain, gut microbiome, and eating behaviors play a crucial role in shaping obesity risk.
Research suggests that owning a family dog during adolescence can boost mental well-being and social support by altering the gut microbiota. The study found that adolescents with dogs had higher mental health scores and lower social problems compared to those without dogs.
Research highlights the connection between fungi and cancer, revealing that fungal microbiome can promote tumour progression and activate immunosuppressive pathways. Modulating the fungal microbiome may enhance antitumour immunity, with preliminary validation from preclinical and clinical trials.
A large-scale laboratory screening identified 168 chemicals toxic to human-made gut bacteria. Washing fruit and veggies before consumption may help avoid exposure to these pollutants. Researchers developed a machine learning model to predict chemical harm, emphasizing the need for safer industrial practices.
A study reveals that competition for biotin, a vital vitamin, drives interactions between harmful Staphylococcus aureus and harmless commensal bacteria. This resource scarcity could lead to new strategies for fighting multi-resistant germs.
A new paper outlines a global coalition dedicated to conserving microbial biodiversity, which accounts for 99% of life on Earth. The Microbial Conservation Specialist Group will develop Red List-compatible metrics, pilot restoration projects, and promote public awareness to ensure microbes are recognized as essential to planetary health.
Research reveals that medications can reshape the trillions of microbes in the gut by competing for nutrients, leading to predictable changes in the microbiome. The study provides a framework for predicting how a person's microbial community might change with a given drug, potentially helping scientists find ways to prevent side effects.
A recent study at UC Davis has shown that feeding cows red seaweed can dramatically cut the amount of methane produced, with a 60% reduction in emissions. The research identified specific microbes in the cow's gut that help reduce methane production, opening the door to engineering these microbes for a long-term solution.
Microbial metabolites from the gut microbiome influence gene expression, cellular function, and host health. The MDME axis proposes a unified theoretical framework explaining this complex dialogue.
A recent study published in The FEBS Journal found that specific gut bacteria can efficiently metabolize different forms of nitrogen, preventing carcinogenic nitrosamine formation. This process is critical for maintaining intestinal and systemic health, potentially decreasing the risk of certain cancers.
A comprehensive review synthesizes current insights into the intricate connections between gut microbiota and sleep regulation, highlighting the crucial role of peripheral organs in modulating brain function and behavior. Disruptions in gut microbiota composition are closely linked to sleep disturbances across multiple disorders.
Research links low body weight in young Japanese women to reduced gut microbial diversity, with an increased presence of inflammatory species. The study suggests that improving eating habits could lead to improvements in gut microbiota and body weight.
A study from the Champalimaud Foundation found that when fruit flies are deprived of essential amino acids, their brains upregulate two olfactory receptor genes involved in smell, leading to a refined sense of smell that guides them to protein-rich yeast and gut bacteria. This interplay between smell and taste regulates feeding behavior.
The intra-tumoral microbiome influences cancer initiation, progression, and immune regulation through various mechanisms. Targeting the tumor microbiota holds promise for precision medicine and cancer therapy.
Scientists found that breathing dusty air from the Salton Sea can alter the lung microbiome and trigger immune responses in mice. The study suggests that chronic exposure to such dust could have significant health effects, including asthma.
Researchers found that voluntary running exercise mitigates cafeteria diet-induced behavioral changes via hormonal and microbial pathways. The study revealed specific metabolites, such as anserine and indole-3-carboxylate, were decreased by the cafeteria diet but partially restored by exercise.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
A healthy microbiome promotes overall well-being, influencing areas like cognition, mood, immunity, and disease susceptibility. By incorporating proven dietary interventions, regular exercise, stress reduction, and adequate sleep, individuals can harness their microbiome for optimal health.
Researchers discovered that non-hibernating pikas alter their gut microbiota to increase urea nitrogen salvaging, maintaining protein homeostasis during winter. This adaptation helps the animals cope with the scarcity of dietary protein during the cold season.