The researchers show that FGF-21 regulates glucose uptake in human fat cells. Moreover, therapeutic administration of FGF-21 decreased plasma glucose levels and triglycerides to near normal levels in multiple mouse models of type 2 diabetes. FGF-21, when overexpressed, protected animals from diet-induced obesity. These results define a functional role for FGF-21 in vivo and provide evidence that FGF-21 can lower glucose and triglyceride levels in diabetic animals.
TITLE: FGF-21 as a novel metabolic regulator
AUTHOR CONTACT:
Alexei Kharitonenkov
Lilly Research Laboratories, Indianapolis, IN USA
Phone: 317-276-0091; Fax: 317-277-2934; E-mail: a.kharch@lilly.com
View the PDF of this article at: https://www.the-jci.org/article.php?id=23606
Journal of Clinical Investigation