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A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries

11.03.22 | PLOS

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A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries
Maps of countries contributing data to the consortium. Sample sizes (cases and controls) for each phenotype were added and represented on the logarithmic scale by each circle. Relative contribution to each phenotype is represented by the three colors. Maps obtained from https://www.naturalearthdata.com/. Credit: Butler-Laporte G, et al., 2022, PLOS Genetics, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries

Article URL: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010367

Article Title: Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

Author Countries : Canada, United States, Italy, Qatar, Germany, Poland, Switzerland, United Kingdom, Spain, Japan, Sweden, Saudi Arabia, Thailand

Funding: see manuscript

PLOS Genetics

10.1371/journal.pgen.1010367

Competing Interests: see manuscript

Keywords

Covid 19 Genetic Variation Health and Medicine Immune System Life Sciences X Chromosomes

Article Information

Journal
PLOS Genetics
DOI
10.1371/journal.pgen.1010367
COI Statement
Competing Interests: see manuscript

Contact Information

Claire Turner
PLOS
plosgeneticspress@plos.org

How to Cite This Article

APA:
PLOS. (2022, November 3). A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries. Brightsurf News. https://www.brightsurf.com/news/LRDWGG58/a-rare-gene-variant-in-the-x-chromosome-tlr7-gene-is-associated-with-a-five-times-greater-risk-of-severe-covid-19-in-study-of-individuals-across-12-countries.html
MLA:
"A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries." Brightsurf News, Nov. 3 2022, https://www.brightsurf.com/news/LRDWGG58/a-rare-gene-variant-in-the-x-chromosome-tlr7-gene-is-associated-with-a-five-times-greater-risk-of-severe-covid-19-in-study-of-individuals-across-12-countries.html.