Researchers developed a system of mathematical equations to examine interactions between interventions and post-infection effects. The team found that even small post-infection costs could shift the optimal vaccine coverage to higher rates, even to elimination levels.
A study of 3,860 nurses and midwives from 18 Latin American and Caribbean countries found recurring patterns of emotional overload, professional challenges, and exposure to multiple forms of violence during the pandemic. The researchers identified three interconnected themes: direct violence, stigma, fear, and disruption of social belo...
Researchers analyzed the Texas All-Payer Claims Database to track Long COVID diagnoses across populations and variant periods. They found that Long COVID diagnoses followed waves of acute COVID-19 infection, with older adults and women having higher rates, and higher rates in rural counties.
A new study reveals that public health officials are facing intense backlash, with 76% experiencing threats or harassment since the start of the COVID-19 pandemic. The researchers identified successful strategies, such as promoting civil discourse and building relationships with local businesses, that may reduce backlash.
Researchers at Gladstone Institutes have discovered how SARS-CoV-2 protein ORF8 hijacks immune cells to cause hyperinflammation, leading to severe lung damage. Blocking ORF8 reduces lung inflammation and damage in mice infected with SARS-CoV-2, offering a promising new path for developing treatments.
A new commentary calls for consistent evaluation of potential links between COVID-19, vaccination, and cancer, highlighting potential associations and biological mechanisms. The author argues that similar mechanisms reported in connection with COVID-19 vaccination warrant consideration and further study.
Researchers at ITQB NOVA discovered that SARS-CoV-2 has two fusion peptides in its spike protein, necessary for entering cells. The peptides work together to initiate membrane fusion, a crucial step for the virus's entry. Understanding this mechanism is crucial for developing strategies to block the virus.
A new study has found a significant link between Long COVID and POTS, with nearly two-thirds of Long COVID participants meeting the diagnostic criteria for POTS. The study suggests that POTS may be contributing to symptoms such as dizziness, fatigue, and brain fog in some individuals with Long COVID.
A study of 60,980 US adults with autoimmune rheumatic conditions found that those who received updated COVID-19 vaccines had a 69% lower adjusted odds of COVID-19-related hospitalization compared to those who received only the initial series vaccines or were unvaccinated. The completion of the initial series and booster vaccination als...
A new study estimates that 45%–55% of governments misreported COVID mortality, with underreporting common than overreporting. Countries with stronger institutional checks and balances show less underreporting, emphasizing the importance of verification in protecting the reliability of official information.
Researchers discovered a lower risk of subsequent type 1 diabetes development among individuals under 30 who had COVID-19, especially among unvaccinated individuals. The study found a 16% reduced risk across all variants combined and a 42% lower risk 31-180 days post-infection.
A new study reveals striking biological similarities between five major illnesses, including long Covid and PTSD, suggesting common underlying mechanisms. Chronic fatigue syndrome, rheumatoid arthritis, and multiple sclerosis may be driven by shared regulatory networks in immune and metabolic systems.
A six-country study of children from before to after the pandemic found that most children's health, learning, social development, and wellbeing recovered substantially. Setbacks persisted among children with pre-existing risks, rather than the pandemic alone.
A clinical trial funded by NIH found that PAXLOVID does not improve Long COVID symptoms, but its extended duration did not cause serious side effects. The study recruited 959 patients and monitored symptoms over six months.
Researchers have identified a subset of B cells known as atypical memory cells as the primary precursors of autoantibody-producing cells during SARS-CoV-2 infection. These cells adopt a markedly different biological program, leading to increased autoantibody production. The study provides new insight into how viral infections can trigg...
A 2-year multicenter cohort study found that most hospitalized survivors maintained or regained cognitive function after Omicron infection, while older and reinfected patients may face progressive decline. The study identified age, infection history, and disease severity as risk factors for progressive decline.
In Nigeria, ethnopharmacology played a culturally important role in the COVID-19 response, with some remedies showing promise, such as IHP Detox Tea and Niprimum, but high-quality RCT data are limited and IP laws inadequately protect traditional knowledge.
A new precision oncology paper critiques the methodology used in a 2025 study on mRNA vaccine residual DNA, arguing that it systematically underestimates DNA impurities. The analysis highlights key methodological flaws, including primer design, sample preparation, and analytical platform limitations.
Researchers have discovered a simple ball-milling process that enhances the antiviral activity of manganese-based oxides, improving their ability to inactivate enveloped viruses like SARS-CoV-2. The findings suggest a promising strategy for designing low-cost, high-performance antiviral materials.
A new viewpoint article in BioScience suggests using multiple working hypotheses and strong inference to break the logjam in the COVID-19 origins debate. The approach, inspired by a 1890 paper, aims to distinguish among competing explanations and improve analytical processes guided by an objective consortium of scientists.
A data analysis on excess deaths was retracted by BMJ Group after concerns were raised about the quality and messaging of the research. The Princess Máxima Centre found no evidence of malicious intent or falsification of data, but concluded that the authors' explanations for excess deaths were misleading and selective.
Researchers have compiled ten fundamental mechanisms governing the development of pandemics, highlighting the importance of understanding biological, mathematical, and social factors. These mechanisms can help improve preparedness and response to future pandemics by identifying key drivers of outbreak dynamics.
Researchers developed a model to optimize countermeasures while considering containment costs, identifying a clear threshold for optimal control. The study found that measures become necessary only when the disease reaches a certain severity, and that vaccination campaigns can help reduce transmission rates.
A recent study found that night shift workers are nearly twice as likely to develop long COVID, with chronic insomnia further increasing the risk. The study, published in the Scandinavian Journal of Work, Environment and Health, highlights the importance of healthy sleep habits in preventing long COVID.
A systematic review and meta-analysis investigated changes in mental health symptoms before and during the COVID-19 pandemic. The study found significant differences in symptom changes between sexes and genders, highlighting the need for targeted interventions.
A recent study found that severe COVID-19 reactivates certain dormant viruses in hospitalized patients, which may contribute to autoimmune disease and chronic conditions. Notably, reactivation of Anelloviridae viruses was associated with long-term physical disability and long COVID.
Researchers found the nucleocapsid protein amplifies inflammatory pathways in macrophages, fueling tissue-damaging immune responses. The study suggests a possible mechanism for cardiac injury seen in severe COVID-19 cases and points to targeted treatments
After COVID-19 pandemic restrictions relaxed, Kawasaki disease incidence rebounded in Japan, with distinct age-dependent patterns. Nonpharmaceutical interventions may have contributed to the observed greater rebound in older children, while infants showed minimal changes, suggesting different exposure pathways.
Researchers at Gladstone Institutes have made significant progress in understanding the causes of long COVID, focusing on changes in virus-specific immune cells. Specifically, they found that people with long COVID have distinctive changes in CD8 T cells, which are specialized to protect against specific viruses.
An observational study found that early remdesivir treatment reduced the risk of all-cause graft loss and cardiovascular events in adult kidney transplant recipients with COVID-19. The study included 432 participants, with 177 receiving at least three days of remdesivir therapy.
A new study in The Lancet Planetary Health shows that when communities designed their own health and livelihood programs with local NGOs, they were more resilient to economic hardships caused by COVID-19. As a result, forest loss declined significantly, with rates 52% lower in supported communities compared to unaffiliated ones.
A new study reveals that Republican lawmakers sponsored 86% of antivaccine bills introduced in state legislatures after the COVID-19 pandemic. Meanwhile, Democratic lawmakers supported provaccine bills, highlighting partisan polarization's impact on vaccine access and public health.
A global vaccine trial evaluated fractional doses of COVID-19 boosters, finding they produced strong immune responses comparable to full-dose boosters. This could lead to extended vaccine supplies, improved equity in vaccination programs and reduced costs, especially in low-income countries.
A study found that children born during the first COVID-19 lockdown in England had lower executive function skills, including difficulty focusing and regulating emotions. Overall language scores were at or above expected levels, but expressive language skills were below average.
Researchers have found that GLP-1 agonists can normalize genetic pathways involved in pulmonary fibrosis, a lung disease associated with Long COVID. The treatment has shown promise in reducing the risk of fibrous buildup, suggesting potential benefits for people with type 2 diabetes and severe COVID-19 symptoms.
A study from Linköping University finds that mild COVID-19 can lead to long-term eye problems, including abnormal pupil function and strabismus, affecting daily life. Researchers developed a diagnostic model to detect these issues, which may lead to effective treatment.
A long-term study by Hiroshima University found that lingering symptoms of COVID-19 became less common after the Omicron variant arrived, but some people continued to experience health problems years after infection. The study showed that recovery from COVID-19 does not always end when the infection clears, and that some individuals ma...
Researchers found that COVID-19 vaccine boosters provide protection against some future coronaviruses that risk spreading from animals to humans. The study also showed that the immune response 'locks in' after the first exposure to SARS-CoV-2, impeding the ability to respond to future variants.
A new study suggests that several COVID-19 drugs can be toxic to marine organisms, even at low concentrations. The research found that ivermectin and other pharmaceuticals caused significant mortality in brine shrimp, highlighting an environmental concern.
A new clinical trial led by University College London researchers found that ten weeks of cognitive rehabilitation can help people with long Covid symptoms such as brain fog achieve their goals in returning to work and hobbies. The treatment yielded benefits that lasted for at least six months for most participants.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
A new study found that job dissatisfaction was the leading reason for nurse turnover, with 2.6 times more likelihood to leave among unhappy nurses. Education also played a role, as current students and those with graduate degrees were more likely to leave their jobs.
A new study published in Clinical Infectious Diseases found that metformin reduced the risk of clinician-diagnosed long COVID by 50% when administered during acute COVID-19 infection. The study, which enrolled nearly 3,000 adults, showed improved long-term outcomes and no safety concerns.
A nationwide survey in Japan found a gradual but steady decline in health-related quality of life among the working-age population over seven years. The study also revealed regional differences in HRQoL across prefectures.
Research by Lancaster University and the Indian Institute of Technology, Kanpur found that vulnerable families coped with food insecurity by limiting food diversity, taking loans, and temporarily withdrawing children from school. The study highlights the importance of local social networks and government support in mitigating crisis.
The DIVINE cohort database contains clinical information from 5,813 COVID-19 patients, including characteristics, risk factors, treatments, and outcomes. The data can be used to study disease progression, identify associated factors, and validate predictive models.
A cohort study found that introducing immunity in US nursing homes was associated with lower overall staffing and staff-to-resident time. During the COVID-19 pandemic, many states adopted immunity from tort liability for harms to nursing home residents.
A new study published in the Journal of the American Heart Association found that adults with better Life's Essential 8 scores had lower odds of becoming severely ill or dying from COVID-19. The research suggests that having a healthy heart helps prepare the body for real-life stress tests, such as infectious diseases like COVID-19.
A new study by the University of Turku found that long COVID patients experience increased brain activity in mood and emotion regions, rather than widespread brain inflammation. The study suggests that treatments targeting stress and emotional regulation may be more effective for patients with prolonged symptoms.
A linseed oil-derived polyol compound has been patented by FIU researchers, exhibiting potential to inhibit a broad spectrum of viral and bacterial infections. The compound's low cost, biodegradability, and industrial scalability make it an attractive option for global health challenges.
A study from Murdoch University found that anger, rather than fear of infection, drives aggressive anti-Asian responses during COVID. The research suggests that addressing anger will be critical in preventing future waves of discrimination.
A recent Chinese Medical Journal study analyzed data from 1990 to 2021, revealing a significant increase in neurological disorders such as dementia, Parkinson's disease, and ischemic stroke. The study identified a turning point coinciding with the COVID-19 pandemic, highlighting the need for coordinated national strategies to address t...
A study from the University of Bath reveals widespread psychological distress among people who remain isolated due to Covid-19. The research found a vicious cycle of fear driving withdrawal from social contact, reducing confidence to re-engage with the world and reinforcing isolation.
A study found that airborne viruses can spread between separated indoor spaces through shared bathroom ventilation systems. The study, conducted in a high-rise building in Spain, confirmed COVID-19 transmission through vertical ventilation shafts, highlighting the risk of disease transmission in older buildings.
A study in Japan found that individuals with higher health literacy regarding gastric cancer and screening, those who perceived themselves to be at risk, and those who received encouragement from others exhibited stronger screening intentions. Concrete implementation intentions were also significantly linked to actual screening partici...
The US had substantially higher death rates between 1999 and 2022 compared to other wealthy nations, with cardiovascular diseases being the leading cause of excess mortality. An estimated 12.7 million US deaths could have been averted during this period if US mortality rates mirrored those of its peers.
A Canadian study found that seasonal COVID-19 vaccination significantly reduced the risk of illness in 2025/26, with vaccine protection extending beyond its target strain. The vaccine was particularly beneficial for people aged 65 or older, offering 53% effectiveness against severe COVID-19.
A study found mitochondrial morphological abnormalities and downregulation of mitochondria-related genes in patients who developed myocarditis after mRNA vaccination. Treatment with antioxidants and pharmacological inhibitors suppressed the condition. Sex hormones may also play a role in preventing cardiac dysfunction.
Researchers used high-frequency ultrasound waves to eliminate viruses such as SARS-CoV-2 and H1N1 by causing structural changes that led to inactivation. The technique uses acoustic resonance, which differs from cavitation, a process used for decontamination.
Researchers discovered that early-stage ectoderm cells are especially susceptible to SARS-CoV-2 infection, with heightened vulnerability driven by elevated TMPRSS2 activity and thinner glycocalyx. This raises concerns about potential developmental risks, particularly for infants born to mothers infected during early pregnancy.