About The Study: This multicenter, case-control study found that the vaccine effectiveness of 2024-2025 COVID-19 vaccines was associated with protection against COVID-19 hospitalization and severe in-hospital outcomes and against multiple JN.1 descendants. Monitoring COVID-19 vaccine effectiveness, including stratifying by SARS-CoV-2 lineage and spike protein mutations, remains important to guide COVID-19 vaccine composition and recommendations.
Corresponding Author: To contact the corresponding author, Kevin C. Ma, PhD, email tra3@cdc.gov .
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(doi:10.1001/jamanetworkopen.2025.57415)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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