SAN DIEGO — Researchers are shedding light on neural mechanisms underlying the progression of Alzheimer's disease. These findings will be presented at Neuroscience 2025, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to symptoms including cognitive decline, memory loss, and the inability to perform daily functions. According to the Alzheimer's Association , it's estimated that 6.9 million Americans were living with AD in 2024; that number is expected to increase. Scientists are working to understand the signs of early disease in the brain before more severe pathologies, including amyloid plaques and neurofibrillary tangles, emerge.
Today’s new findings show that:
"As exciting as it is to see new disease-modifying treatments for Alzheimer’s becoming available, it’s equally important that we empower people with knowledge and tools to protect their own brain health. Evidence-based lifestyle choices can reduce the risk of Alzheimer’s and support long-term cognitive health,” said Sharyn Rossi, PhD , senior director of neuroscience programs at BrightFocus Foundation and moderator of the press conference. “Our role is not only to advance treatments, but also to ensure the public understands the steps they can take today to safeguard their brain health.”
For complete access to Neuroscience 2025 in-person and online, request media credentials . This research was supported by national funding agencies including the National Institutes of Health and private funding organizations.
Sunday, November 16, 2025
3–4 p.m. PST
San Diego Convention Center, Room 15A, and online for registered media
Alzheimer’s Disease Press Conference Summary
Prediction of mild cognitive impairment to Alzheimer's dementia using excitation-inhibition imbalance
Guoshi Li, guoshi_li@med.unc.edu , Abstract PSTR323.23
Impact of Alzheimer’s disease on suprachiasmatic nucleus connectivity, sleep regulation and circadian rhythm
Satchin Panda, panda@salk.edu , Abstract PSTR156.10
The night watch: how midlife sleep guards neural networks underlying memory in Alzheimer’s
Frank Raven, frankra@umich.edu , Abstract PSTR156.25
Impact of Combination Therapies on Alzheimer's Disease-Related Outcomes in a Humanized APP/APOE AD-Risk Model During Midlife
Roberta Diaz Brinton, rbrinton@arizona.edu , Abstract PSTR437.12
Altered Mitochondrial Function and Inflammation in Humanized APP/APOE Mouse Model of Alzheimer’s Disease Risk
Roberta Diaz Brinton, rbrinton@arizona.edu , Abstract PSTR437.06
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The Society for Neuroscience (SfN) is an organization of nearly 30,000 basic scientists and clinicians who study the brain and the nervous system.