Transdermal delivery of biologics like extracellular vesicles (EVs) holds great promise for regenerative medicine and dermatological therapy. However, the stratum corneum poses a formidable barrier, especially for large and delicate molecules such as EVs. While microneedles (MNs) offer a minimally invasive solution, long needles (≥600 μm) often cause pain and irritation, and short needles struggle with limited penetration depth. Now, researchers from Sungkyunkwan University, led by Prof. Changhyun Pang and Prof. Jae Hyung Park, have developed a bio-inspired, dual-amplified transdermal patch (MN@EV/SC) that enables pain-free, uniform, and deep delivery of EVs using short microneedles.
Why This Matters
Innovative Design and Features
Applications and Future Outlook
This work highlights the power of bio-inspired engineering in overcoming biological barriers and opens new avenues for EV-based therapeutics. Stay tuned for more innovations from Prof. Pang and Prof. Park’s teams at Sungkyunkwan University!
Nano-Micro Letters
Experimental study
A Hierarchical Short Microneedle‑Cupping Dual‑Amplified Patch Enables Accelerated, Uniform, Pain‑Free Transdermal Delivery of Extracellular Vesicles
23-Jul-2025