Climate change continues to threaten the world’s coral reefs, which support at least a quarter of all marine life. Though probiotics have been shown to rehabilitate corals in aquarium experiments, demonstrating the efficacy of such microbial therapy in the ocean is difficult. In a study publishing in the Cell Press journal Cell Reports on September 3, researchers establish that both live probiotic and inactivated postbiotic treatments improve coral health—while the animals are under thermal stress during a natural marine heatwave.
“We want a future with coral reefs in it,” says co-lead author Erika Santoro, a postdoctoral fellow at the King Abdullah University of Science and Technology in Saudi Arabia. “We urgently need to understand both the natural mechanisms that allow some corals to tolerate heat and how we can safely enhance those mechanisms.”
Corals host a number of beneficial bacteria, including types that help them adapt to their environment. The aim of microbial therapy is to restore not just the corals themselves but also the microbiomes they sustain. Probiotics, in this case, are groups of living microbes obtained from healthy corals that may be applied to stressed corals.
Postbiotics, on the other hand, are inactivated probiotics and/or their bioactive components. A major goal of the study was to see whether postbiotics could also boost coral health.
“The possibility of using postbiotics is particularly exciting when we think about scaling microbial therapies,” Santoro says. “Inactivated microbial formulations could potentially offer practical advantages, such as longer shelf life, easier storage and transportation, and reduced production costs.”
Santoro and colleagues treated Acropora cf. valida coral in the central Red Sea during a summer 2022 heatwave. Throughout the 15-day field experiment, daily average seawater temperatures ranged from 87.6°F to 89.5°F (30.9°C to 31.9°C). The team isolated beneficial bacterial strains from Red Sea corals to concoct two probiotic treatments and their postbiotic counterparts.
Next, they measured coral health by evaluating the animals’ colors—white or “bleached” hues indicate poor health—and the photosynthetic efficiency of the algae that live inside them. After 15 days of treatment, one of the probiotic and one of the postbiotic formulas had significantly improved coral health.
“When an innovative idea like this actually works—particularly under field conditions—we are positively surprised,” Santoro says. “The most exciting takeaway is that this study opens a new avenue for coral microbial therapies.”
The researchers also ran genetic and metabolic tests on the treated corals, which revealed that the probiotic and postbiotic therapies had restructured their microbial and metabolic profiles in different ways. Specifically, postbiotic-treated corals showed an increase in strains of Cobetia , a kind of bacteria that helps corals tolerate heat stress.
More research is needed to understand the mechanisms behind the treatments’ success, Santoro says, especially for postbiotics.
“We see approaches such as probiotics and postbiotics as additional tools that could help improve coral resilience and support restoration efforts, while broader actions address the causes of climate change,” Santoro says.
###
This work was supported by the King Abdullah University of Science and Technology and the Ocean Science and Solutions Applied Research Institute, Education, Research, and Innovation Sector, NEOM, Tabuk, Saudi Arabia.
Cell Reports , Santoro et al., “Probiotic and postbiotic treatment in situ during a marine heat wave improves coral health and promotes specific metabolic and microbiome changes” URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00917-4
Cell Reports ( @CellReports ), published by Cell Press, is a weekly open-access journal that publishes high-quality papers across the entire life sciences spectrum. The journal features reports, articles, and resources that provide new biological insights, are thought-provoking, and/or are examples of cutting-edge research. Visit http://www.cell.com/cell-reports . To receive Cell Press media alerts, contact press@cell.com .
Cell Reports
Experimental study
Animals
Probiotic and postbiotic treatment in situ during a marine heat wave improves coral health and promotes specific metabolic and microbiome changes
3-Sep-2026