Osaka, Japan – The truth is out there – but identifying signs of life in space involves an intense search for biosignatures within our solar system and beyond. However, developing sensitive, yet compact, technologies capable of detection has proven to be an out-of-this-world challenge.
However, this may be set to change, as researchers at the University of Osaka have developed an electrical method that could be used to detect extraterrestrial life. This exciting discovery is set to be published in Nature Communications .
Identifying both living beings and nonliving chemicals and processes relies on amino acids, the building blocks for proteins. Amino acids have the same chemical formula but possess two mirror image forms, capable of distinguishing the living from the nonliving. For living creatures, almost all amino acids are exclusively in the L-form, with sugars existing in the D-form. By contrast, nonliving chemical and physical processes produce both L- and D-forms in equal abundance.
Consequently, the L/D ratio is a potential biosignature of life, making amino acids an ideal target for astrobiology research. Traditional methods distinguish samples by measuring large groups of molecules, presenting researchers with practical challenges. It has been suggested that an alternative method involving electrical detection would be simpler, less sensitive to vibrations, and circumvent the use of chemical reagents.
Recent developments in nanotechnology were harnessed to electrically detect single molecules of biological relevance. To do this, the team measures molecules passing through a gap between two gold nanowires, which generates an electrical tunneling current. As the current waveforms of each form of amino acid are different from one another, the team could directly count the number of molecules passing through the gap.
“By combining our nanogap tunneling technique with artificial intelligence, we were able to distinguish between the L- and D-forms of amino acids with over 80% accuracy,” says lead author, Takahito Oshiro. “This is the first discrimination of amino-acid chirality at the single-molecule level and constitutes a fundamental advance in chemical sensing.”
As astrobiological samples typically contain many types of molecules, the team tested whether the technique could be used to identify amino acids in complex mixtures.
“We analyzed natural samples from the Murchison meteorite in Australia and soil samples from the Atacama Desert in Chile,” explains senior author, Masateru Taniguchi. “Our method was comparable to traditional methods, as both were capable of capturing the major features of amino acid composition.”
It is hoped that these developments could be used to create compact, electrically based instruments, capable of detecting extraterrestrial life.
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The article, “Chiral discrimination of amino acids in meteorite and desert soil extracts via single-molecule nanogap conductance”, will be published in Nature Communications at DOI: 10.1038/s41467-026-77947-6
About The University of Osaka
The University of Osaka was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world. Now, The University of Osaka is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.
Website: https://resou.osaka-u.ac.jp/en
Nature Communications
Experimental study
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Chiral discrimination of amino acids in meteorite and desert soil extracts via single-molecule nanogap conductance
5-Oct-2026