The Alliance for Lupus Research has awarded nearly $7 million to researchers globally, funding over 100 projects and committing $50 million to research since its founding in 1999. The grants focus on removing barriers to new treatments and therapies for lupus, a disease affecting disproportionately women of color.
A landmark genetic study identified multiple genes linked to systemic lupus erythematosus (SLE), a debilitating autoimmune disease affecting joints, kidneys, heart, lungs, brain and blood. The findings will ultimately lead to new therapies and earlier diagnosis, with 13 strong candidates supported by data that are 99% accurate.
Researchers discovered that SpA, a staph protein, causes B cell suicide in mice. Properly dosed injections of SpA may control immune system over-activity and potentially treat lupus. The study provides a promising lead for future development of B-cell based therapy.