Researchers identified a novel glycosyltransferase enzyme, PamUGT, from American pokeweed, which can decorate five major classes of natural products. The enzyme shows remarkable promiscuity, using multiple UDP-sugars to glycosylate diverse substrates.
Researchers discover and evaluate marine peptides with improved efficiency using green solvents, enzymatic hydrolysis, and membrane separation. Bioinformatics tools help predict structures and functions of these peptides, offering potential candidates for various diseases.
Researchers found Xijiaqi Formula reduces neuroinflammation and promotes neuroplasticity in CHF rats, improving cognitive function. The formula also enhances molecular signatures of neuroplasticity by regulating PDE4-cAMP/PKA/CREB signaling.
Researchers use AI methods to tackle complexity of TCM formulas, predicting pharmacokinetic behavior and identifying synergistic interactions. AI-assisted modeling helps connect constituents to protein targets, supporting iterative cycles of prediction and experimental confirmation.