A novel function of noncoding RNA in senescence and cancer
Researchers discovered that noncoding RNA derived from pericentromeric repetitive sequences upregulates SASP-like inflammatory gene expression by disturbing chromatin interactions. hSATII RNA is highly detectable in cancer cells and supports tumor development via small EVs, highlighting a new role in age-related pathologies.
SourceJapanese Foundation For Cancer Research·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 23, 2021