Researchers have discovered that cholesterol molecules facilitate hedgehog protein function by causing its split and acting as an anchor, highlighting the importance of cholesterol in developmental processes.
A clinical trial by investigators at the Johns Hopkins Children's Center found that teenage girls with iron deficiency performed significantly better on verbal learning tests than those who took a placebo. The study suggests that even in the absence of anemia, iron deficiency may impair learning in adolescent females.
A Johns Hopkins study found that high-risk gastrointestinal surgery patients are less likely to die if treated at hospitals performing more complex procedures, without increased costs. The study's lead author notes that Maryland's unique data collection system contributed to the findings.
Researchers found that a drug called MK-801 can reduce brain cell death during cardiac surgery by blocking glutamate receptors. The study used dogs and showed promising results, suggesting a potential new approach to preventing brain damage during heart surgery.
Researchers developed a new technique to measure electrical impulses in the trigeminal nerve, a major nerve in the jaw. The technique accurately measured the nerve's electrical impulses, helping researchers determine normal levels for electrical activity in these branches.
A Johns Hopkins study found that motor nerve grafts were more effective in regrowing nerve fibers than sensory nerve grafts. This breakthrough may lead to improved treatments for individuals with facial nerve injuries and other nerve damage, allowing for the restoration of movement while minimizing numbness or paralysis.
Researchers at Johns Hopkins Medicine discovered a peptide that closes an NMDA glutamate receptor, potentially aiding the development of stroke treatment drugs. The peptide, known as Mag-1.5, can help regulate communication between nerve cells and may provide insights for potential new therapies.
Researchers at Johns Hopkins have found that spending more time and money on strict drug regimens saves money in the long run. The cost-effective strategy, called directly observed therapy (DOT), cures more people sooner and decreases the risk of developing TB germs resistant to treatment.
A Johns Hopkins study found that over 1 in 5 neurologists and obstetricians had patients with epilepsy who developed unwanted pregnancies due to anti-epilepsy drugs interfering with birth control pills. Increasing birth control medication levels or switching to non-interfering medications can reduce the risk of unplanned pregnancy.
Scientists have developed a new vaccine that uses an anti-idiotype antibody to stimulate the immune system and prevent Chlamydia trachomatis infections, which affect 700 million people worldwide. The vaccine was effective in animal experiments and may be available for humans with further development.
A Johns Hopkins study finds that removing career obstacles for women in academic medicine benefits men as well, increasing promotion expectations by 29% and reducing consideration of leaving by 42%. The interventions led to a 66% increase in women's expected promotions and a 63% decline in those considering leaving.
A recent study by Johns Hopkins Medicine has identified a genetic mutation that may be associated with an increased risk of osteoporosis. The mutation, found in the calcium-sensing receptor gene, was discovered in people with primary hyperparathyroidism and showed no link to this condition, but may play a role in other bone diseases.
A very low protein diet with amino acid supplements has been shown to cure severe kidney disease in some individuals. The study suggests that this dietary therapy should be tried before drug treatment for nephrotic syndrome, which often leads to kidney failure.
A recent study by Johns Hopkins Medicine detected genetic mutations specific to cancer in blood samples of six patients with head and neck cancer. The presence of DNA alterations in the blood was associated with large, advanced tumors and poor outcomes, including increased mortality rates.
A study led by Johns Hopkins researchers found that positive messages nearly doubled the pain threshold and tolerance of both groups, while negative messages lowered it. The results suggest that addressing both biological and emotional causes is crucial for pain treatment.
Researchers at Johns Hopkins Medicine have identified a protein glitch as an early problem in inherited Alzheimer's disease. Presenilin normally cleaves in two, but a disease-causing mutation can prevent this crucial change. This study may lead to new treatments by targeting the point of cleavage with drugs or other interventions.
The implant is a button-sized polymer that releases hydromorphone over one to three months, providing steady pain medication. It could be used in developing nations where cancer rates are high but limited treatment options exist, and potentially as an alternative to oral methadone treatment for heroin addicts.
Thyroid screening can prevent mild problem from becoming severe and reverse undiagnosed symptoms, according to a Johns Hopkins study. Screening costs are comparable to other preventative tests, with greatest savings from lowering cholesterol and heart disease risk.
A new study by Johns Hopkins Medicine reveals that testosterone replacement therapy may improve visual and spatial skills, as well as verbal fluency and memory in men with low testosterone. The findings suggest a potential role for testosterone in cognitive function and brain function.
A Johns Hopkins study found that declining testosterone levels in HIV-positive men can predict weight loss and increased risk of death. Researchers measured testosterone in 26 men and discovered a significant decline in hormone levels among those who experienced weight loss.
Research from Johns Hopkins Children's Center reveals that African-American children are 16.4 times more likely than Caucasian children to be sensitive to cockroach allergens, highlighting the link between race and asthma. The study also found that poor children and those from urban areas are more susceptible to roach infestation.
A Johns Hopkins study found that fires occur in 17% of commuter and air taxi crashes, resulting in 536 deaths and 744 injuries. The researchers emphasize the need for adoption of latest fire safety technology to minimize risk of fire in these aircraft.
Scientists found that brains of patients with Lesch-Nyhan disease have fewer nerve endings containing dopamine, a chemical messenger controlling movement. This discovery is crucial in developing future treatments for the disorder.
Researchers at Johns Hopkins Medicine found that squalamine, a shark liver substance, nearly stops the growth of new blood vessels that nourish solid brain tumors. The study showed a significant reduction in tumor cell growth and slowed the formation of new blood vessels by up to 83% after two days.
A year-long study found that nearly twice as many smokers made progress toward quitting in church-based programs with pastoral support compared to self-help pamphlets. The programs emphasized cultural and spiritual norms, particularly among Baptists who consider smoking a sin, leading to higher quit rates.
Researchers at Johns Hopkins Medicine have identified unique molecular footprints on the biochemical trail leading the immune system to attack its own tissues in scleroderma. Exposure to toxic oxygen products causes tissue molecules to break apart, exposing hidden parts that trigger an immune response.
A new study published in The Journal of Plastic and Reconstructive Surgery found that non-invasive magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) can effectively manage vascular malformations. The imaging techniques showed the growths' connections to surrounding tissues, allowing for better treatment planning.