Researchers at Mayo Clinic found that the protein p120 catenin can both suppress and promote metastasis, depending on its interaction with cadherin proteins. The study suggests that a future designer drug could block the beginning of metastasis or stop it once it starts.
Researchers investigated the impact of two copies of the G2019S Parkinson's gene mutation on disease severity. They found no observable differences in symptoms, age of onset, or life expectancy between those with two copies and those with only one copy.
Mutations in the progranulin gene cause frontotemporal dementia (FTD), a group of brain disorders affecting personality and speech. The discovery reveals the mechanism that causes the disease and points to potential therapeutic approaches.
A recent study found that the LRRK2 gene mutation is associated with Parkinson's disease in several families, indicating a genetic component of the disease. The mutation was identified in 22 out of 42 family members who carried the G2019S mutation, and all shared a common ancestral pattern.
Researchers found a mutation in the LRRK2 gene that plays a central role in developing Parkinson's disease and other neurodegenerative disorders. The discovery has major implications for understanding mechanisms of these diseases and potentially leading to curative treatments.
A Mayo Clinic study found that over one-third of adults aged 45+ had plaque buildup on their aortic valves, increasing the risk of hardening and narrowing of the aorta. Lifestyle changes can help prevent life-threatening complications. Risk factors include male gender, high blood pressure, obesity, and elevated homocysteine levels.
Researchers at Mayo Clinic have successfully bred mice with both amyloid plaques and neurofibrillary tangles, the key pathologic hallmarks of Alzheimer's disease. The double transgenic mouse model provides a more complete representation of human AD and will enable researchers to test therapies aimed at preventing or halting progression.
Scientists at Mayo Clinic have identified a region on chromosome 10 as a potential contributor to late-onset Alzheimer's disease, affecting amyloid β protein processing. Researchers hope to discover the associated gene and potentially identify individuals at risk before they develop the disease.