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Science News for August 31, 2001


Masking genetic mutations

Scientists have identified an important parallel between C. elegans and human NMD pathways, revealing a potential therapeutic strategy for masking genetic mutations. Inactivation of the human homolog of the C. elegans smg-1 gene inhibits NMD, allowing truncated proteins to accumulate and potentially compensate for genetic disorders.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateAug 31, 2001

Mayo Clinic study: Echocardiogram spots risk of valve narrowing, stroke

A Mayo Clinic study found that over one-third of adults aged 45+ had plaque buildup on their aortic valves, increasing the risk of hardening and narrowing of the aorta. Lifestyle changes can help prevent life-threatening complications. Risk factors include male gender, high blood pressure, obesity, and elevated homocysteine levels.

SourceMayo Clinic, Jacksonville·JournalJournal of the American College of Cardiology·DateAug 31, 2001

Nature's chemical weapons save lives

Researchers at Texas A&M University have discovered a marine compound, pateamine A, with immunosuppressive properties. The study could lead to the development of new immunosuppressive drugs, and pharmaceutical companies are already inquiring about licensing the compound.

The genetics behind miniature plants

Researchers identified BONZAI1 as a central player in Arabidopsis plant growth homeostasis. The gene influences plant size at different temperatures, with mutant cells failing to grow normally at cooler temps. A related protein, BAP1, was also found to interact with BONZAI1 and is more highly expressed at lower temps.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateAug 31, 2001

Study finds lower dose of mifepristone still effective when used with misoprostol in early termination of pregnancy

A recent study published in Obstetrics and Gynecology found that a lower dose of mifepristone is as effective as higher doses when used with misoprostol for early pregnancy termination. The study showed that 72 out of 80 women experienced complete abortions after using the lower dose regimen.

SourceUniversity of Pittsburgh Medical Center·JournalObstetrics and Gynecology·DateAug 31, 2001

DOE contract to study combustion chemistry

Professor Terrill Cool's research uses flame-sampling photoionization mass spectrometry to detect key-reaction intermediates in laboratory flames. The new facility will produce average photon fluxes 100 times larger than current sources, enabling more accurate predictive models of combustion kinetics.

Mega-tsunami to devastate US coastline

A new model predicts a mega-tsunami could devastate the US coastline, with wave heights reaching 100 meters on the West Saharan shore and 50 kilometers high in Florida. The energy released would be equivalent to the electricity consumption of the entire United States in half a year.

SourceUniversity College London·JournalGeophysical Research Letters·DateAug 31, 2001