Mitochondrial oxidative stress is a key driver of autoimmune diseases, with each disease having unique barriers to treatment. The review proposes a single therapeutic target, targeting the interconnected regulatory network of five pathways, including NRF2, AMPK, SIRT1, and mitophagy.
Correspondence in Medicine Discovery argues that the quality of public database research rests on the study process, while the database name provides little information about scientific quality. Databases themselves are not the problem, but rather the production model that exploits them.
A new framework proposes evidence sufficiency, selective prediction, and deferral pathways for multimodal AI in cardiovascular medicine. Missing data are not noise, but rather informative about patient state, clinician decisions, and health system access.
A review grades the evidence behind 38 ATP-induced cell death genes, identifying direct and indirect evidence, context-dependent mechanisms, and insufficient evidence. The review also releases a public gene resource, ATPexGen, to summarize what is known about AICD.
The editorial highlights the gap between prioritization and mechanism in brain multi-omics research, emphasizing the need for functional testing and harmonized metadata to establish biological meaning and clinical relevance. It proposes three complementary strategies: dynamic comparisons, joint measurements, and targeted perturbation e...