The UniProt database will consolidate existing protein databases SWISS-PROT, TrEMBL, and PIR to provide a non-redundant source of protein information. The new database aims to facilitate research on human disease and translate basic science into clinical applications.
The new guide aims to overcome barriers for researchers to access and effectively use the wealth of freely available human genomic data. The NHGRI team provides practical instructions for searching and analyzing genomic data using major genome portals, such as Map Viewer, Genome Browser, and Ensembl.
A study published in Nature Genetics reveals a gene mutation underlying Amish microcephaly, a birth defect marked by a small head and brain size. The researchers found that the defect disrupts mitochondrial function, leading to abnormal brain development.
The National Human Genome Research Institute (NHGRI) has upgraded the priority of cow, dog, Oxytricha trifallax, and Trichoplax genomes to high or moderate based on medical and biological opportunities. The genome sequences are expected to speed up studies of these agriculturally important animals and have medical benefits for dogs.
The CEGS program supports interdisciplinary research in genomics and its applications in understanding human biology and disease. Two new grants will focus on vertebrate diversity and cell signaling, potentially leading to major insights into genome changes that underlie evolution and human biology.
The new site organizes institute information into seven major categories, including Research, Health, and Careers. NHGRI's commitment to ELSI and educational resources make it a valuable resource for the public and professionals.
A study published in Nature Medicine found that mice without a functional vitamin C transporter gene died shortly after birth due to severe health problems. The research suggests that vitamin C plays a crucial role in fetal lung development, which could have implications for premature infants and pregnant women.
Scientists have identified a specific gene, RNASEL, in the HPC1 region linked to hereditary prostate cancer in some families. The study found mutations that inactivate this cellular self-destruct mechanism, explaining why some prostate cells become cancerous.
Researchers found a genetic signature that divides patients with advanced melanoma into subgroups, offering clues to the disease's biology. This discovery could lead to more accurate prognosis and tailored therapies.
Researchers have sequenced the genome of Caenorhabditis elegans, a tiny worm with similarities to humans. The completed genome reveals over 19,000 protein-coding genes and sheds light on human biology.
A new gene, AIB1, has been discovered in breast cancer cells that amplifies their growth. The gene is part of a family known as SRC-1 and interacts with steroid hormone receptors, enhancing tumor cell growth.
Scientists at the NIH have identified a gene abnormality causing some cases of Parkinson's disease, which affects nerve cells and dopamine production. The discovery provides a new tool for understanding cellular abnormalities in Parkinson's disease and connects it to research on Alzheimer's disease.
Astronomers have found powerful accelerators of material close to home, in our own galactic neighborhood, as nearby black holes with jets. The jets appear to move at velocities approaching the speed of light and are thought to be connected to the accretion disk and surrounding regions.
The 1996-1997 Human Genome Lecture Series featured nine speakers who discussed various aspects of the human genome, including genome sequencing, comparative genomics, and genetic research in specific populations. The series aimed to provide a comprehensive understanding of the human genome and its implications for genetics research.
Researchers at NASA's Marshall Space Flight Center are experimenting with Aerogel, the lightest solid material known, in space to learn how to make it transparent. The goal is to create an insulating material for energy-efficient windows that conserve energy and save money.
Scientists have identified a major gene, HPC-1, that predisposes men to prostate cancer, located on chromosome 1. The gene is believed to contribute to at least a third of familial prostate cancer cases.
Researchers identify a gene on chromosome 4 as a potential cause of Parkinson's disease, shedding light on the mysterious origins of this debilitating condition. The discovery may lead to genetic testing, early diagnosis, and treatment options for all forms of Parkinson's disease.
Scientists have developed a powerful new way to visualize the full set of human chromosomes using spectral karyotyping, which translates computer-gathered light waves into a full-color palette. This technique enables easy examination of chromosome changes that could lead to disease, such as missing or extra pieces.