Researchers identified thousands of potentially functional SNPs associated with changes in gene expression, highlighting the unique value of using iPSC-derived neurons as a model. The study advances understanding of genetic causes of neuropsychiatric disorders and offers a path to novel disease treatments.
The DNA10K initiative will engage over 10,000 patients with genomics testing, providing personalized risk factors for hereditary conditions. Patients will have access to genetic counselors and clinical pharmacists to interpret test results and develop individualized care plans.
A study of three genes associated with prostate cancer found that men with inherited mutations are more likely to develop aggressive forms and die earlier. The study suggests that germline mutations in these genes can be used to predict risk for lethal prostate cancer.