Peking University-College of Engineering

New dimensions of cryo-electron microscopy uncover ‘multiverse’ of cancer targets for enabling drug discovery

A research team led by Professor Youdong Mao has developed a new method using time-resolved cryo-electron microscopy and machine learning-based 4D reconstruction to visualize the USP14-proteasome system in atomic detail. This reveals a 'multiverse' of parallel reality pathways, allowing for targeted inhibition of cancer cells.

SourcePeking University-College of Engineering·JournalNature·TypeExperimental study·DateMay 22, 2022

Scientists decode dynamics of the largest protein-degrading machine in atomic detail

Researchers used cryo-EM to visualize the dynamic process of substrate processing in the human proteasome at unprecedented resolution, revealing single magnesium ions bound to ATP and ADP. The study provides novel insights into the complete cycle of substrate processing and suggests distinct modes of ATP hydrolysis.

SourcePeking University-College of Engineering·JournalNature·DateFeb 24, 2019