Researchers identified a gene defect underlying childhood-onset osteoporosis in two Finnish families and four additional families worldwide. The SGMS2 gene mutation causes changes in bone metabolism and mineralisation, leading to severe short stature and disturbed bone development.
A study published in Annals of Oncology found that one course of chemotherapy or radiotherapy after surgery does not have a long-term effect on sperm count and concentration in men with early stage testicular cancer. Sperm number and concentration recovered in all groups up to five years after treatment.
Researchers used cryo-EM to visualize the dynamic process of substrate processing in the human proteasome at unprecedented resolution, revealing single magnesium ions bound to ATP and ADP. The study provides novel insights into the complete cycle of substrate processing and suggests distinct modes of ATP hydrolysis.
A multi-year observational study found that eating small amounts of peanut after immunotherapy can extend allergy treatment benefits and improve quality of life. The majority of participants continued regularly eating peanuts daily for up to eight years without any reactions from accidental ingestions.
A study of 800 Swedish women found that those with high levels of mental activities like reading, singing, and gardening were 46% less likely to develop Alzheimer's disease. Women who were physically active also had a reduced risk of developing dementia, with a 52-56% lower risk compared to inactive participants.
A new report suggests that incentivizing downsizing for 'last-time buyers' aged 55+ can ease the UK's housing crisis. The report highlights the role of financial services in expanding mortgage offerings and insurance policies to help older people monetize their housing wealth, thereby funding retirement and covering care costs.
A national longitudinal study found that school-based health centers contribute to academic achievement among adolescents, with immunizations and physical exams associated with higher educational attainment. However, individual-level emotional counseling was inversely associated with educational attainment.