A recent publication in Molecular Therapy unveiled the promise of HDT Bio Corp.’s AMPLIFY vaccine platform combining self-replicating RNA (repRNA) with its localizing cationic nanocarrier (LION™) formulation. The preclinical data showcased a more favorable safety profile and increased efficacy of repRNA vaccines delivery with LION tech...
Researchers discuss inhibiting glutamate receptors as a promising approach for treating chronic pain, migraine and muscle spasticity. Glutamate receptor antagonists like tezampanel have shown potential in clinical trials for treating various conditions.
Researchers measured breast cancer patients' upper limb volume before and after surgery to establish a baseline and monitor for lymphedema. The study found that early detection using compression garments effectively treated subclinical lymphedema.
A new microarray technology enables fast and accurate enrichment of thousands of targeted genomic regions for high-throughput sequencing. This method replaces PCR-based approaches, allowing for the resequencing of entire genomes or specific genes in a cost-effective and efficient manner.
Researchers identified a virus, Israeli Acute Paralysis Virus (IAPV), as a leading candidate in the deaths of tens of billions of bees. The study found that IAPV was only present in collapsed colonies, suggesting a possible causal relationship between infection and Colony Collapse Disorder.
Researchers produced human cardiomyocytes from hESCs using a sequential, directed differentiation protocol that did not rely on serum or feeder cells. Echocardiography showed attenuation of left-ventricular end-diastolic and end-systolic diameters in animals receiving cardiomyocytes compared to control groups.
A retrospective study identified rare drug-resistant HIV variants in blood samples from an earlier clinical trial using ultra-deep sequencing. The findings suggest that even low-level mutations can lead to early treatment failure, highlighting the need for improved resistance testing methods.