Researchers at Immerge have identified that human-tropic PERV is acquired during life, rather than being present in the germ-line DNA of mini-swine. The study found no viruses in the germ-line DNA that could infect human cells, paving the way for safer xenotransplantation procedures.
New lab results show no recombination of porcine and human retroviruses, reducing the risk of PERV transmission to humans. This finding supports Immerge's progress toward clinical xenotransplantation research.
Researchers achieved best survival to date with islet cells from swine, reversing insulin dependency in diabetic cynomolgus monkeys. The study showed no evidence of antibody-mediated rejection, a major type of organ rejection, and demonstrated the potential for xenotransplantation.
Immerge BioTherapeutics has identified the PERV receptor, a key factor in understanding the safety of xenotransplantation. This breakthrough allows for the development of safer porcine organs for human transplantation, addressing an unmet need in clinical transplantation.
Scientists have successfully cloned the world's first double knock-out miniature swine, eliminating a major hurdle in xenotransplantation research. The genetically modified pigs lack the gene GGTA1, which triggers an immune response against pig organs.
A new study using gene therapy has shown promise in treating Parkinson's disease by 'resetting' overactive brain cells. The therapy may arrest or delay disease progression, offering a safer and more powerful alternative to current treatments.
Researchers at Immerge BioTherapeutics have identified miniature swine that do not transmit the pig retrovirus (PERV) to humans. The study characterizes three sub-classes of PERV A, B and C found in the herd of inbred miniature swine, showing consistent non-transmitting phenotypes.