Researchers found that patients with a negative pretransplantation scan had a favorable outcome, with 25 still in complete remission after a median follow-up of 1,510 days. In contrast, patients with a positive scan relapsed more frequently, highlighting the potential for [F]FDG-PET to identify nonresponders.
Researchers used ultrafast light pulses to visualize the speed distribution of electrons in Rydberg atoms, revealing their wave-like behavior. This study provides new insights into the interaction between light and slow-moving electrons.
Researchers at St. Jude Children's Hospital have successfully treated four pediatric patients with retinoblastoma using a combination of chemotherapy, radiation therapy, and stem-cell transplantation. The study shows promising results, with two out of four patients surviving for over six years without disease recurrence.
The EVAP-COND software simulates the performance of evaporators and condensers with various cooling agents, enabling engineers to optimize designs. This tool helps conserve energy while reducing laboratory testing and design-to-production time.
Researchers used acoustic measurements to recognize differences in vowel pronunciation among 160 Dutch and Flemish teachers. The study found that acoustic methods can map sociological differences in pronunciation with high accuracy, outperforming phonetic transcription methods which require manual expert analysis.
Finasteride has been shown to prevent prostate cancer in both low-risk and high-risk men. However, those on finasteride were more likely to develop high-grade cancers.
A ferret protein called glucose-6-phosphate isomerase (GPI) plays a key role in the reproductive process, allowing fertilized embryos to implant successfully. The discovery also sheds light on the mechanism of cancer cells, which can co-opt this process to invade healthy tissues.
Contrast-enhanced MRI is a reliable method to measure blood flow to tumors, allowing for accurate assessment of chemotherapy response and tumor viability. The study found that patients who responded to treatment had significant decreases in angiogenesis, while non-responders showed increases.
The National Institute of Standards and Technology has developed a new instrument to study the metal of World Trade Center (WTC) steel. The apparatus rapidly compresses and heats samples at extremely high temperatures, helping to improve understanding of how steel responds under stress.
Women taking long-term combined HRT face a significant increase in breast-cancer risk, doubling the risk for invasive lobular and ductal breast cancer. The study found that both sequential and continuous progestin regimens were associated with similar increases in breast-cancer risk.
The study showed that FDHT-PET detected osseous lesions in patients with advanced metastatic prostate cancer, confirming its utility in evaluating prostate cancer patients. The test also revealed the presence of additional lymph node lesions not identified by CT scans, suggesting its potential to predict response to hormone therapy.
Researchers discover that Alzheimer's protein amyloid beta is transported into the brain by riding piggyback on a larger molecule called RAGE. This discovery opens up new possibilities for treating the disease. By blocking RAGE, blood flow to the brain can be restored and amyloid plaques reduced.
FDG PET demonstrates high accuracy for diagnosing infection and inflammation, with a sensitivity of 93% and specificity of 84%, according to a study analyzing 844 scans on 806 patients.
Researchers tested 'reverse CPR' on critically ill patients in intensive care units, improving average systolic and arterial blood pressure. The new approach could lead to better treatment outcomes in the community setting.
A PET scan study found that only a combination of methylphenidate and a behavioral stimulus resulted in increased dopamine levels. The increases were associated with improved perception of the task as interesting and motivating.
Researchers at Johns Hopkins Medicine found that pancreatic cancer may be triggered by the reactivation of a growth signal normally turned off in adult tissues. By blocking this pathway, they hope to prevent the early cellular changes leading to cancer.
Research suggests that individuals with higher education levels exhibit less cognitive decline in Alzheimer's disease due to increased brain adaptability and flexibility. The study, which analyzed autopsied brains of deceased participants, found a significant association between education and reduced AD pathology.
New guidelines improve pregnancy, labour, and delivery care for HIV-positive women. These updated recommendations allow for longer, healthier pregnancies and increased chances of healthy, HIV-free offspring.
Recent national surveys in the UK show that full-time employment remains dominant, while careers are not dead and job tenure has increased. The study also reveals that new technologies have not revolutionized the work experience of all employees, and labour markets have yet to experience any radical transformation.
Researchers at the University of Toronto have devised a new architecture for manufacturing photonic band gap materials, increasing available bandwidth for optical microchips. The technique uses x-rays to create a precise template, allowing for high-quality silicon photonic band gap materials.
The microPET Focus offers significant improvements in image resolution and system sensitivity compared to its predecessor. The new design features reduced detector crystal cross-sections and gap sizes, resulting in improved spatial resolution and increased sensitivity.
Researchers at Vanderbilt University Medical Center conducted a double-blind, randomized, controlled study involving 240 participants with high cholesterol. The study showed a 16% reduction in low-density lipoprotein (LDL) cholesterol after taking green and black tea extracts enriched with the antioxidant theaflavin for 12 weeks.
Researchers used microPET and optical CCD imaging to track transplanted rat cardiac cells, detecting higher uptake in areas where cells were transplanted compared to background tissues. This study provides valuable insight into cell transplant biology, enabling real-time monitoring of engrafted cells.
A new study found that Neoral is as effective as tacrolimus in preventing acute rejection but better tolerated, with lower rates of diabetes and diarrhoea. The study analyzed 499 patients and showed significant differences in tolerability between the two immunosuppressive therapies.
A study by Joanna Fowler and colleagues found significant reductions in MAO B activity in the heart, lungs, kidneys, and spleen of smokers compared to non-smokers, with reductions ranging from 33 to 46%. The findings suggest that smoking impacts peripheral organs and highlight the need for further examination of these consequences.
The NIAID is distributing the GeneChip SARS Array at no cost to qualified researchers worldwide, providing a powerful tool to better understand the SARS coronavirus and its spread. The array will help scientists achieve objectives such as constructing a family tree of SARS coronaviruses and tracing the virus's evolution.
A new technique allows for the growth of silicon nanowires and carbon nanotubes directly onto a microchip, eliminating cumbersome middle steps in sensor manufacturing. This method enables the production of ultra-sensitive biochemical sensors and early-stage disease detectors that can detect single viruses or toxic agents.
A study by Dr. Pio and colleagues found that FLT-PET imaging outperforms FDG-PET in predicting tumor response to chemotherapy in breast cancer patients. The researchers compared the two imaging modalities in 11 newly diagnosed patients, taking scans before treatment began, after the first dose, and following the final cycle.
A new study suggests radiosynoviorthesis is effective in treating osteoarthritis, providing significant pain relief to 2/3 of patients with proven synovitis. The procedure, which involves removing inflamed membrane using beta-emitting radionuclides, shows promise as a treatment option for OA.
A recent study found that heart failure patients cared for by cardiologists had significantly lower one-year death rates compared to those treated by other types of physicians. The study analyzed data from 38,702 Canadian patients and found that cardiologist-managed patients had a mortality rate of 28.5%, compared to 31.7% for general ...
FDHT PET detected 46 lesions, outperforming conventional methods, which identified 59. The agent rapidly absorbed in metastatic lesions indicating functioning androgen receptors. Notably, FDHT uptake reduced in patients starting testosterone therapy.
The Society of Nuclear Medicine has announced an image that represents a significant advance in achieving high throughput in PET scanning without sacrificing quality. The image showcases technology such as 3D-LSO PET/CT, which could decrease whole-body scan duration substantially, benefiting nuclear medicine professionals and patients.
A high C-reactive protein (CRP) level is an independent risk factor for stroke, with higher levels more closely related to stroke in people with thicker artery walls. Elevated CRP may denote plaque instability, increasing the likelihood of a blood clot forming and causing a stroke.
Researchers at the University of Illinois discovered that birds play a crucial role in protecting Neotropical forests by consuming leaf-eating insects. By eating caterpillars on leaves, birds drastically reduce damage to foliage, with average damage levels increasing by 86% where they could not reach.
A study using PET scans found that schizophrenics have elevated dopamine receptor levels in both basal forebrain and SN/VTA areas of the brain. Differences were observed in cortical dopamine levels, supporting the hypothesis of dysregulated neurotransmission leading to abnormal regulation of neurons.
A study found that people with diabetes in Saskatchewan accounted for $134.3 million in health care expenditures, with major comorbidities contributing to 36.4% of these costs. Targeted strategies to prevent diabetes could produce substantial savings and improved health outcomes.
A study by the American Academy of Neurology found that people with patent foramen ovale, a common heart condition, are at increased risk of stroke after air travel. Researchers analyzed data from over 155 million passengers and found that six percent of those who developed pulmonary embolism had strokes.
A team of researchers from Michigan and Connecticut has received an award for their work on a new antibiotic, linezolid. The drug is the first of its kind to be approved in 35 years and shows promise in treating serious Gram-positive infections that are resistant to conventional antibiotics.
A new species of the gentian family, Macrocarpaea apparata, has been discovered in Ecuador. The plant was found to have yellowish-white bell-shaped flowers that emerge only as darkness falls, mirroring the magical concept of apparition.
Scientists have discovered a layer of cells in the inner retina containing melanopsin, which enables certain animals to synchronize their biological rhythms with day/night cycles. Melanopsin-free mice were unable to react normally to light stimuli and synchronize their rhythms.
Researchers have identified a molecular fingerprint unique to individuals with HIV-associated dementia (HAD), suggesting the potential development of a simple blood test for its diagnosis. The study used proteomics to analyze protein patterns in patients and found correlations between certain proteins and HAD.
A three-year project studies the Dhyanna of Entering into Non-Conceptuality, an 8th-century scripture considered authentic Buddha's teaching. The research aims to show similarities between Chinese and Tibetan Buddhism and how they have been interpreted differently throughout the ages.
The study found that intracoronary infusion of progenitor cells after acute myocardial infarction (AMI) significantly increased mean signal intensity (MSI) in areas with AMI damage, regardless of the type of progenitor cells used. The treatment showed a positive effect on myocardial viability.
A study found that PET-CT scans were more accurate than PET scans alone in staging non-small cell lung cancer patients. The combined imaging technique correctly identified lung cancer with chest wall and vascular spread, downgrading tumor severity in 13.3% of cases.
A study by William Strange and Stuart Rosenthal found that start-up companies are strongly attracted to cities with similar companies nearby, diverse businesses, and outsourcing services. Cities play a vital role in providing new business growth and innovation for countries like Canada.
Researchers found that MYC binds to the WRN gene promoter, activating WRN expression and promoting cellular senescence in tumor cells. This discovery suggests a potential therapeutic target for cancer treatment by inhibiting WRN in MYC-induced tumor cells.
Researchers compared MPI and CCTA scans to determine a more comprehensive assessment of coronary artery disease. Combining functional SPECT MPI and anatomic CT scans provided valuable information on severe myocardial perfusion defects and calcium deposits.
Dr. Pfefferle, known as the 'father of catalytic combustion,' has developed a process to reduce nitrogen oxide emissions from gas turbines. His inventions include the Microlith(r) catalytic reactor and RCL™ catalytic combustor, enhancing combustion efficiency and air quality.
The medical publishing industry has seen a significant acceleration in its pace of production, driven by technological advancements and innovative strategies. This shift is expected to have a positive impact on the quality and timeliness of medical research and knowledge dissemination.
A new study found that repair enzymes can 'distinguish' between various positions on the DNA strand, varying in effectiveness depending on their orientation relative to the nucleosome. This discovery has significant implications for our understanding of DNA repair and its role in preventing diseases like cancer and Alzheimer's.
Researchers used MRI to assess brain function while participants experienced heat stimuli. People who reported higher pain levels showed increased activation in key brain areas, such as the primary somatosensory cortex and anterior cingulate cortex. This confirms the importance of self-reports in guiding pain treatment.
Researchers at Rush University Medical Center found that higher education is associated with better memory and learning ability in individuals with Alzheimer's disease. The study, published in Neurology, suggests that formal education may provide a cognitive reserve that reduces the effects of AD brain abnormalities.
A new SPECT collimator pair increases sensitivity, particularly in central brain structures, while maintaining spatial resolution. The best combination of fan-beam and cone-beam collimation has been found to greatly improve dual-head SPECT images.
Scientists investigated how day length affects soybean flowering, finding early flowering is more active and controlled by small developing leaves or buds. The study's results could help develop cultivars adapted to short growing seasons for northern Canadian soybean producers.
Researchers discuss new findings on HIV-associated dementia and its potential association with the presence of MDM. Additionally, studies suggest that treating post-Lyme disease with antibiotics does not provide benefits, while a possible link is found between insulin and Alzheimer's disease risk factors.
A recent study suggests that I-123 Altropane SPECT imaging can detect dopamine deficiency in patients with drug-naïve ADHD. The study's results indicate a higher binding ratio of the radiopharmaceutical to dopamine transporters in ADHD patients, supporting the idea of a potential diagnostic tool.
A recent study evaluated eZ-Scope's performance in identifying radioactive nodes during sentinel node biopsy. The results showed that eZ-Scope allowed for more accurate identification of nodes in less time.
Dr. Nora D. Volkow, the first woman to lead NIDA, has made significant contributions to understanding addiction through imaging studies. Her extensive publication record and awards recognize her as a leading expert in the field of drug addiction research.
Researchers used video sequences of people, soap operas, and radio shows to investigate face recognition. They found that for unfamiliar faces, memory appears dominated by external features, but once familiar, internal features become more important.
Researchers found that late-identified reading deficits can manifest differently among students, with some having difficulty comprehending text or identifying printed words. The study highlights the need for schools to use varied assessments and tailored intervention programs to address individual students' strengths and weaknesses.