Research at the University of Alabama at Birmingham found that mice exposed to cigarette smoke and fed a liquid diet containing ethanol had a 4.7-fold increase in artery lesions, compared to those breathing filtered air and eating a normal solid diet.
A new study found that Forteo significantly increased bone density measurements, particularly in the lumbar spine and hip, compared to Fosamax. The findings suggest Forteo may be a valuable treatment option for secondary osteoporosis caused by glucocorticoid use.
A combination of common anti-HIV drugs tenofovir and emtricitabine with nevirapine during labor significantly reduces the risk of HIV-positive pregnant women developing resistance to a class of drugs, potentially improving future treatment options.
Researchers at University of Alabama at Birmingham discovered a key cell-signaling pathway regulating cell growth and patterning in tadpoles. The study found that modification of histone protein H2A influences normal cell pathways and cell growth.
A new study published in JAMA found that antiretroviral drug therapy and non-physician care, such as nursing, are essential in saving the lives of HIV-infected African children. The research showed significant improvements in CD4 cell counts and weight-for-age scores among children treated with antiretrovirals.
The UAB Center for Education and Research on Therapeutics has won a $3.8 million grant to continue its research on the safety and effectiveness of new therapeutics for inflammatory, arthritic, and musculoskeletal diseases. The funding will also support efforts to reduce treatment disparities among minority communities.
A new study from the University of Alabama at Birmingham found that garlic compounds can liberate hydrogen sulfide in red blood cells, leading to vessel relaxation. This effect is believed to be behind the protective effects of garlic on cardiovascular health.
A UAB research team will lead the NF Consortium, a nine-institution group studying neurofibromatosis type 1. The $5.7M grant will focus on clinical trials testing new treatments for adults and children with NF.
Pertuzumab prolongs survival time for women with Stage 3 ovarian cancer, a Phase II clinical trial found. The experimental drug added weeks to the standard survival period and was well-tolerated by the body.
Researchers found that administering hydrogen sulfide directly into the heart during a simulated heart attack significantly reduces tissue and cell damage. The study showed a 72% reduction in severe heart-tissue death after restoring normal oxygen and blood flow.
Researchers at UAB found that resveratrol, a compound in red wine, reduces prostate cancer risk by 87% in male mice. The study also showed that resveratrol slows tumor growth in less-serious forms of prostate cancer.
A new study found that inhaling nitric oxide during liver transplantation reduces hospital stays and improves blood-clotting and liver-enzyme activity. The treatment also protects transplanted livers from cell death, promising relief for donor-organ shortages.
Researchers found SIVcpz infection in up to 35% of chimpanzees in West Africa, allowing for genetic comparisons between HIV-1 and its simian counterpart. The study provides insights into the origins of HIV-1 and how it made the jump from animals to humans.
Two surgical interventions, primary peritoneal drainage and laparotomy, were compared in a clinical trial involving 117 preterm infants with perforated NEC. The study found that the type of operation performed did not influence survival or other clinically important outcomes.
A massive study of 100,000 individuals found that Caucasians have the highest prevalence of hemochromatosis/iron overload due to a specific gene mutation. In contrast, Asian and Pacific Islanders have high blood iron levels despite lower genetic mutations, suggesting a different underlying cause.