Dr. Jennifer Gillette is studying the role of hematopoietic stem cells in directing the creation of new blood vessels at the site of a crisis, such as a heart attack. Her research aims to improve treatment responses for heart disease and potentially benefit cancer patients who receive hematopoietic stem cell transplants.
Researchers at the University of New Mexico Cancer Center have identified a first-in-class chemical compound, CID2950007, that inhibits Cdc42 GTPase activity, controlling cell migration and adhesion. This novel compound shows promise in preventing cancer metastasis and may also be effective against infectious diseases.
Abnormalities in DNA repair mechanisms are a hallmark of cancer cells, leading to increased errors and genetic mutations. The UNM Cancer Center researcher is investigating the role of enzymes that repair DNA damage, aiming to identify new targets for cancer therapy.
Researchers at the UNM Cancer Center are studying GPER, a novel estrogen receptor, to develop potential therapies for breast cancer. By understanding how GPER influences tumor growth and metastasis, they aim to create more effective treatments that can reduce resistance to existing drugs.
A study on histone modification could lead to targeted drugs for cancer treatment. Dr. Osley's research focuses on how ubiquitin attaches to H2B and its impact on DNA copying, potentially targeting quiescent cancer cells.
A UNM Cancer Center researcher is investigating the link between mitochondrial DNA and ovarian cancer. She hopes to identify genetic markers that could lead to a screening test or therapy, potentially increasing survival rates.
UNM Cancer Center researchers have identified R-ketorolac as a potential treatment for ovarian cancer cells, using flow cytometry and computer modeling to target specific GTPases. Initial animal studies show promising results in controlling tumor growth.
Scientists focus on RNA processing differences in cancer cells to understand their role in tumor development. Alternative RNA splicing occurs more frequently in cancerous cells, but its biological importance is unknown.