A study published in Cancer Research reveals that the Zika virus selectively kills aggressive human embryonal CNS tumor cells in vitro and in vivo. The virus was effective at concentrations as low as one viral particle per ten cells, with no impact on differentiated neurons.
A study published in Cell reveals that tumor cells can be tracked using stemness indices, which help understand cancer progression. The researchers used machine learning algorithms on genomic data from 12,000 samples to identify molecular characteristics of healthy stem cells and differentiated cells.
Researchers found genetic clues to distinct susceptibility to virus infection in congenital Zika syndrome, using Brazilian twin babies with different outcomes. The study revealed a single gene cannot explain the cases of CZS development nor brain resistance to Zika virus.
A recent proposal to reorganize the traditional dinosaur family tree has sparked debate among experts. However, a new analysis by an international consortium found that the current model of an Ornithischia-Saurischia split remains supported, albeit with weak evidence for an alternative arrangement.
A study published in Cell Host & Microbe reveals that a Plasmodium surface-protein is essential for the malaria parasite's life cycle in mosquitoes. The discovery provides a new approach to block transmission and offers hope for developing vaccines or drugs to alleviate malaria suffering.
Researchers have created a new library of human stem cells with different levels of admixed European, African and Native American genomic ancestry. The cell lines can be used to test drug toxicity and study differential drug response.
A baby born with Zika infection remained infected for two months and one week after birth, showing delayed psychomotor development and spastic hemiplegia. The virus may have been sexually transmitted, as the father also showed symptoms before his wife.
The Brazilian Zika virus strain causes significant damage to mouse fetuses, leading to cell death and impaired growth. In vitro experiments confirm the virus's lethal effects on human nervous system cells, mirroring the development of congenital malformations like microcephaly.
A vast reef system spanning 10,000 km2 has been discovered at the Amazon River mouth, contradicting long-held assumptions about reef development. The ecosystem thrives under a plume layer due to chemosynthesizing microorganisms, supporting complex biodiversity in low light conditions.
Researchers developed a novel, more accurate classification system for gliomas using molecular profiles of 1122 cells. The study identified seven categories for tumor progression assessment, providing a more precise way to predict patient outcomes and treatment responses.