Articles tagged with Biotechnology
A study from Institute of Science Tokyo reveals how histone variants direct DNA methylation to jumping genes, preventing accidental gene silencing in plants. This molecular framework enables plant cells to distinguish transposons from genes, ensuring precise epigenetic regulation across the genome.
Researchers at Dongguk University have developed an innovative gene switch that uses electromagnetic fields to control gene expression. The switch, which targets the Lgr4 gene, demonstrates precise activation with no detectable adverse effects, making it a promising platform for non-invasive gene therapies.
Researchers developed a flexible microsystem to deliver light directly to internal cancer treatment sites, overcoming the limitation of traditional PDT. The system, powered wirelessly and containing tiny light-emitting components, shows promising results in laboratory tests, paving the way for more precise and effective cancer treatments.
The new integrations provide enterprise AI agents direct access to live, structured research data from Dimensions' 430M+ interconnected records. This allows for AI-assisted analytics across one of the world's most comprehensive linked views of global research activity.
Researchers explore bacterial extracellular vesicles as a tool for cancer diagnosis and treatment, with potential for targeted delivery of therapeutic molecules and immunotherapy. However, consistency and safety remain major challenges in this emerging field.
Scientists created a platform that pinpoints genetic triggers for microbes to produce new chemicals and materials. The method enables rapid, precise reprogramming of bacteria as biotechnology tools, supporting the domestic production of valuable products.
Lehigh University researchers develop comprehensive mathematical model of the neural circuitry linking the gut and brain to regulate stomach function, opening new pathways for treating chronic digestive disorders through targeted vagus nerve stimulation. The digital twin could help accelerate therapy development and improve quality of ...
The University of Tennessee is expanding its research excellence with the addition of eight exceptional researchers, tackling pressing challenges in fields like precision health, advanced computing, and sustainable materials. The new faculty members bring expertise that builds on the university's strengths and solidifies its standing a...
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Researchers found perilla oil supplementation significantly prolonged platelet function and reduced inflammation in healthy smokers. The study also showed increased levels of omega-3 fatty acids and antioxidants in the body.
Wearable sensors can track dynamic changes in uric acid levels, providing valuable information for assessing healing progress and adjusting treatment plans. Researchers have improved the accuracy and reliability of these sensors using new materials and technologies.
Scientists from the University of Osaka created an autonomous solid-state nanopore that can sense molecules, generate electrical signals, and retain memories of recent events. The device continuously changes its structure through chemical reactions, creating a dynamic sensing environment that responds to molecules passing through it.
A new wearable sticker system has been developed to simplify diagnostic sweat testing for cystic fibrosis, a genetic disorder affecting digestion and breathing. The innovative technology is reliably accurate and makes the test more accessible beyond specialized centers.
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
Researchers at the University of Manchester have developed a new family of antifungal agents that are more potent and less toxic than existing treatments. The compounds, which were discovered through genome mining, showed increased antifungal activity and improved solubility compared to existing drugs.
Researchers have developed an oxidation-free approach to oligonucleotide synthesis using P(V)-fluoridates, enabling rapid coupling and automated synthesis. The new platform offers improved efficiency and stability compared to conventional methods.
Researchers identify AXL as a previously unrecognized regulator of bone formation, promoting osteoblast maturation and increasing bone mass. Inhibiting Axl using BGB324 increases bone growth in mice without significant toxicity.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers developed a soft, stretchable antenna that can maintain stable wireless connections even during movement. The antenna's design allows it to compensate for changes in shape and size, enabling wearable devices to track vital signs continuously and reliably.
Researchers developed a new cell-based approach to produce several sugars naturally found in human breastmilk, including complex oligosaccharides. The method involves engineering cultured mammalian cells to express essential enzymes, allowing for the production of structurally diverse HMOs with potential applications in infant nutrition.
Researchers found that specific bacterial genera on litchi peel act as a 'freshness clock' predicting fruit freshness with high accuracy. They also isolated a strain that inhibits postharvest pathogens, providing a safe alternative to synthetic fungicides.
Researchers developed an artery-on-a-chip platform to predict ischemic stroke risk by replicating a patient's specific vascular structure and blood flow dynamics. The tool, called a 'physical twin,' reveals that three-dimensional vascular shape and local flow disturbances matter more than simple narrowing in predicting stroke risk.
A study has shown that a peptide isolated from a Brazilian frog can increase the shelf life of strawberries by up to five days. The molecule preserves the fruit's firmness and chemical composition without affecting its flavor, offering a potential new approach to extend postharvest treatment.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
Scientists have developed a method to encapsulate enzymes in a protective molecular cage, enabling efficient and recyclable reactions at high temperatures. This breakthrough has far-reaching implications for sustainable chemical manufacturing and could lead to the creation of new products in industries such as cosmetics.
A new model, PSIDMViT, combines anatomy, physics, and machine learning to predict accurate dose distributions for CyberKnife radiation therapy. The study shows improved agreement with Monte Carlo reference doses and reduced computation time, suggesting a promising strategy for improving radiotherapy dose prediction.
A review study reveals diverse metabolite families containing atypical atoms, including fluorine, selenium, arsenic, and boron, with distinct biological functions and properties. These elements shape natural products with structural and functional versatility, paving ways toward sustainable biotechnologies.
A team at TUM has developed a process to produce crucial amino acids from carbon dioxide, hydrogen, and renewable energy. The approach converts solar energy into electricity, generating hydrogen that is then converted into methanol and eventually into amino acids.
A new automated workflow called Pathogen2Read streamlines bacterial sample preparation for genetic sequencing, reducing hands-on preparation time from a full day to under 45 minutes. This innovation enables small labs to participate in outbreak-monitoring networks and improve response times.
Recent advances in organic photosensitizers for tumor photodynamic therapy enhance reactive oxygen species generation and tumor-killing efficacy. Molecular-structure engineering, nanodelivery systems, and multimodal combination-treatment strategies improve therapeutic outcomes.
Scientists at Murdoch University mapped the genes of Salinivibrio bacteria from Rottnest Island's salt lakes, revealing their potential for producing biodegradable plastic. The study found seven new genes that may enable some strains to break down the plastic.
A new study published in Chinese Neurosurgical Journal found that real-time MRI and brain function monitoring during neurosurgery can improve the removal of tumors affecting the corpus callosum more effectively and safely. This multimodal approach gave patients about 30 extra months after treatment before the tumor grew back or worsene...
Researchers use CRISPR-Cas9 to edit red perilla, producing green plants with increased levels of antioxidants and anti-inflammatory compounds. The study demonstrates a new strategy for developing high-value crops for the food and pharmaceutical industries.
Researchers identified a precise gene edit that lowers cadmium in rice grains while maintaining yield and essential mineral nutrients. The OsNramp5 I441T mutation selectively limits cadmium translocation, reducing grain cadmium by 48% without compromising zinc or manganese uptake.
SLAS Discovery highlights innovative screening platforms accelerating therapeutic discovery for neurodegenerative diseases, including a newly identified link to Alzheimer's progression. The journal showcases novel technologies and approaches to understand and treat human disease, advancing life sciences discovery and technology.
Researchers analyzed 49 journal articles on bacterial cellulose-derived carbon electrodes for supercapacitors, finding that preservation of the nanofiber network and mechanical properties are crucial for performance. The study highlights BCC's potential to outperform commercial activated carbon under comparable conditions.
A new study suggests venture capital is playing a significant role in driving innovation in radiology, particularly in medical devices and artificial intelligence. The study found $11.4 billion was invested across 646 companies between 2000-2023, with funding peaking in 2021.
This volume of SLAS Technology highlights novel laboratory technologies, open-source software, and disease-specific tools for advancing life sciences research and development. The journal emphasizes the importance of education, knowledge exchange, and global community building to drive innovation in biomedical research.
Researchers at MIT have created a precise way to engineer artificial blood vessels by mechanically stretching and pulling a "blood vessel on a chip". The new method, reported in the Proceedings of the National Academy of Sciences, enables controlled sprouting of new vessels and programming of their growth patterns.
Reducing carbon dioxide concentration improves microbial production of biodegradable plastic, such as poly[(R)-3-hydroxybutyrate]. Lower CO2 levels trigger adaptive cellular responses that enhance carbon utilization efficiency.
Researchers developed an analytical technique to evaluate culture media quality by analyzing patterns of fluorescence from synthetic polymer probes. This technology detects quality differences in serum, stem cell, and microbial cultures with high precision, improving reproducibility.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
Recent studies have challenged the classical view of immune checkpoints as local suppressive molecules only active in tumor immunity. Instead, ICs participate in systemic immune homeostasis and are embedded in broader inflammatory and metabolic networks.
Bacteriophages, viruses that naturally infect bacteria, can be engineered into rapid and highly specific biosensors for clinical diagnosis, food safety, and environmental monitoring. These phage-based systems offer a compelling alternative to conventional methods, which often involve tradeoffs between speed, sensitivity, and cost.
Researchers from BST and IGTP are developing therapies based on extracellular vesicles, which can perform tissue regeneration and modulate inflammation. These nanoparticles could revolutionize medicine by delivering medicines directly to damaged tissues.
Researchers have developed a new anticancer immunotherapy technology that selectively eliminates key substances released by cancer cells and boosts the patient's immune response. This 'nanoswitch' technology uses laser therapy to reactivate beneficial extracellular vesicles that induce anticancer immunity.
The ORIGIN project aims to reduce development timelines for sustainable, fermentation-based ingredients from 5-7 years to 2-3 years. By combining AI, biotechnology, and fermentation, the project will address scientific and technological challenges to produce high-value natural ingredients.
A new study explores an FMQA-based optimization framework for RNA design, revealing that encoding matters in achieving optimal results. The approach identifies high-quality RNA sequence candidates with relatively few evaluations, outperforming competing methods.
A team of researchers has successfully created an artificial protein motor that can perform tasks such as cell division and muscle movement with high efficiency and precision. The breakthrough, published in Nature Nanotechnology, demonstrates the feasibility of designing dynamic proteins capable of performing movements.
A new study suggests that pairing iron and manganese modified biochar with carefully chosen irrigation strategies can reduce cadmium and mercury buildup in rice. FMBC helped stabilize both metals while reshaping microbial processes to control methylmercury formation.
Recent studies have expanded our understanding of immune checkpoint functions, revealing their involvement in systemic immune homeostasis and broader inflammatory networks. Aberrant IC regulation has been linked to various conditions, including infections, autoimmune diseases, and metabolic inflammation.
Researchers have successfully produced genome-edited T cells that can target and destroy cancer cells using the Platinum TALEN genetic engineering technique. The technique was found to be efficient, with an average yield of 72 million 1G4-TCR cells for every 3 million T-cells.
Researchers have developed a microfluidic platform that recreates the complex ecosystem surrounding pancreatic tumors and observed how cells interact dynamically. The findings reveal a critical mechanism that may explain why many therapies fail and point to new therapeutic strategies.
A new gene circuit technology has enabled cells to autonomously generate programmed responses, processing multiple molecular signals at once. The RATEX platform allows cells to compute and respond to various types of molecular information.
BetaDescribe, an AI system, converts protein sequences into detailed textual descriptions of their functions and characteristics. The technology helps bridge the gap between characterized and existing proteins in nature, enabling researchers to rapidly generate evidence-based hypotheses regarding unknown proteins.
Researchers have discovered that advanced brain interfacing technology used for both touch and vision prostheses is almost identical, despite being developed separately. This breakthrough could lead to faster restoration of lost senses, including sight and motor function, with a unified technology that benefits both patient groups.
Researchers at ISTA have developed a way to guide AlphaFold with experimental data, enabling the model to better reflect physical and biological reality. This approach aims to improve future predictive models by accounting for structural heterogeneity and dynamism in proteins.
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Researchers developed a pH-triggered nanocomposite that synchronizes the release of therapeutic agents, combating bacterial biofilms and oxidative stress. The platform accelerates healing and promotes tissue repair in infected wounds.
A POSTECH research team has created an automated, modular system for assembling reconstituted cell-free systems, significantly reducing costs by 95% and preparation time to 2 days. This innovation enables the customization of individual components, paving the way for improved biologically engineered high-value therapeutics.