Researchers developed a new cell-based approach to produce several sugars naturally found in human breastmilk, including complex oligosaccharides. The method involves engineering cultured mammalian cells to express essential enzymes, allowing for the production of structurally diverse HMOs with potential applications in infant nutrition.
Researchers found that specific bacterial genera on litchi peel act as a 'freshness clock' predicting fruit freshness with high accuracy. They also isolated a strain that inhibits postharvest pathogens, providing a safe alternative to synthetic fungicides.
Researchers developed an artery-on-a-chip platform to predict ischemic stroke risk by replicating a patient's specific vascular structure and blood flow dynamics. The tool, called a 'physical twin,' reveals that three-dimensional vascular shape and local flow disturbances matter more than simple narrowing in predicting stroke risk.
A study has shown that a peptide isolated from a Brazilian frog can increase the shelf life of strawberries by up to five days. The molecule preserves the fruit's firmness and chemical composition without affecting its flavor, offering a potential new approach to extend postharvest treatment.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
Scientists have developed a method to encapsulate enzymes in a protective molecular cage, enabling efficient and recyclable reactions at high temperatures. This breakthrough has far-reaching implications for sustainable chemical manufacturing and could lead to the creation of new products in industries such as cosmetics.
A team at TUM has developed a process to produce crucial amino acids from carbon dioxide, hydrogen, and renewable energy. The approach converts solar energy into electricity, generating hydrogen that is then converted into methanol and eventually into amino acids.
A new automated workflow called Pathogen2Read streamlines bacterial sample preparation for genetic sequencing, reducing hands-on preparation time from a full day to under 45 minutes. This innovation enables small labs to participate in outbreak-monitoring networks and improve response times.
A new model, PSIDMViT, combines anatomy, physics, and machine learning to predict accurate dose distributions for CyberKnife radiation therapy. The study shows improved agreement with Monte Carlo reference doses and reduced computation time, suggesting a promising strategy for improving radiotherapy dose prediction.
A review study reveals diverse metabolite families containing atypical atoms, including fluorine, selenium, arsenic, and boron, with distinct biological functions and properties. These elements shape natural products with structural and functional versatility, paving ways toward sustainable biotechnologies.
Scientists at Murdoch University mapped the genes of Salinivibrio bacteria from Rottnest Island's salt lakes, revealing their potential for producing biodegradable plastic. The study found seven new genes that may enable some strains to break down the plastic.
Recent advances in organic photosensitizers for tumor photodynamic therapy enhance reactive oxygen species generation and tumor-killing efficacy. Molecular-structure engineering, nanodelivery systems, and multimodal combination-treatment strategies improve therapeutic outcomes.
SourceELSP·JournalBiofunctional Materials·TypeLiterature review·DateJul 20, 2026
A new study published in Chinese Neurosurgical Journal found that real-time MRI and brain function monitoring during neurosurgery can improve the removal of tumors affecting the corpus callosum more effectively and safely. This multimodal approach gave patients about 30 extra months after treatment before the tumor grew back or worsene...
Researchers use CRISPR-Cas9 to edit red perilla, producing green plants with increased levels of antioxidants and anti-inflammatory compounds. The study demonstrates a new strategy for developing high-value crops for the food and pharmaceutical industries.
Researchers identified a precise gene edit that lowers cadmium in rice grains while maintaining yield and essential mineral nutrients. The OsNramp5 I441T mutation selectively limits cadmium translocation, reducing grain cadmium by 48% without compromising zinc or manganese uptake.
SLAS Discovery highlights innovative screening platforms accelerating therapeutic discovery for neurodegenerative diseases, including a newly identified link to Alzheimer's progression. The journal showcases novel technologies and approaches to understand and treat human disease, advancing life sciences discovery and technology.
Researchers analyzed 49 journal articles on bacterial cellulose-derived carbon electrodes for supercapacitors, finding that preservation of the nanofiber network and mechanical properties are crucial for performance. The study highlights BCC's potential to outperform commercial activated carbon under comparable conditions.
A new study suggests venture capital is playing a significant role in driving innovation in radiology, particularly in medical devices and artificial intelligence. The study found $11.4 billion was invested across 646 companies between 2000-2023, with funding peaking in 2021.
This volume of SLAS Technology highlights novel laboratory technologies, open-source software, and disease-specific tools for advancing life sciences research and development. The journal emphasizes the importance of education, knowledge exchange, and global community building to drive innovation in biomedical research.
Researchers at MIT have created a precise way to engineer artificial blood vessels by mechanically stretching and pulling a "blood vessel on a chip". The new method, reported in the Proceedings of the National Academy of Sciences, enables controlled sprouting of new vessels and programming of their growth patterns.
Reducing carbon dioxide concentration improves microbial production of biodegradable plastic, such as poly[(R)-3-hydroxybutyrate]. Lower CO2 levels trigger adaptive cellular responses that enhance carbon utilization efficiency.
Researchers developed an analytical technique to evaluate culture media quality by analyzing patterns of fluorescence from synthetic polymer probes. This technology detects quality differences in serum, stem cell, and microbial cultures with high precision, improving reproducibility.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
Recent studies have challenged the classical view of immune checkpoints as local suppressive molecules only active in tumor immunity. Instead, ICs participate in systemic immune homeostasis and are embedded in broader inflammatory and metabolic networks.
Bacteriophages, viruses that naturally infect bacteria, can be engineered into rapid and highly specific biosensors for clinical diagnosis, food safety, and environmental monitoring. These phage-based systems offer a compelling alternative to conventional methods, which often involve tradeoffs between speed, sensitivity, and cost.
Researchers from BST and IGTP are developing therapies based on extracellular vesicles, which can perform tissue regeneration and modulate inflammation. These nanoparticles could revolutionize medicine by delivering medicines directly to damaged tissues.
Researchers have developed a new anticancer immunotherapy technology that selectively eliminates key substances released by cancer cells and boosts the patient's immune response. This 'nanoswitch' technology uses laser therapy to reactivate beneficial extracellular vesicles that induce anticancer immunity.
The ORIGIN project aims to reduce development timelines for sustainable, fermentation-based ingredients from 5-7 years to 2-3 years. By combining AI, biotechnology, and fermentation, the project will address scientific and technological challenges to produce high-value natural ingredients.
A new study explores an FMQA-based optimization framework for RNA design, revealing that encoding matters in achieving optimal results. The approach identifies high-quality RNA sequence candidates with relatively few evaluations, outperforming competing methods.
Recent studies have expanded our understanding of immune checkpoint functions, revealing their involvement in systemic immune homeostasis and broader inflammatory networks. Aberrant IC regulation has been linked to various conditions, including infections, autoimmune diseases, and metabolic inflammation.
A team of researchers has successfully created an artificial protein motor that can perform tasks such as cell division and muscle movement with high efficiency and precision. The breakthrough, published in Nature Nanotechnology, demonstrates the feasibility of designing dynamic proteins capable of performing movements.
A new study suggests that pairing iron and manganese modified biochar with carefully chosen irrigation strategies can reduce cadmium and mercury buildup in rice. FMBC helped stabilize both metals while reshaping microbial processes to control methylmercury formation.
A new gene circuit technology has enabled cells to autonomously generate programmed responses, processing multiple molecular signals at once. The RATEX platform allows cells to compute and respond to various types of molecular information.
BetaDescribe, an AI system, converts protein sequences into detailed textual descriptions of their functions and characteristics. The technology helps bridge the gap between characterized and existing proteins in nature, enabling researchers to rapidly generate evidence-based hypotheses regarding unknown proteins.
Researchers have successfully produced genome-edited T cells that can target and destroy cancer cells using the Platinum TALEN genetic engineering technique. The technique was found to be efficient, with an average yield of 72 million 1G4-TCR cells for every 3 million T-cells.
Researchers have developed a microfluidic platform that recreates the complex ecosystem surrounding pancreatic tumors and observed how cells interact dynamically. The findings reveal a critical mechanism that may explain why many therapies fail and point to new therapeutic strategies.
Researchers have discovered that advanced brain interfacing technology used for both touch and vision prostheses is almost identical, despite being developed separately. This breakthrough could lead to faster restoration of lost senses, including sight and motor function, with a unified technology that benefits both patient groups.
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Researchers at ISTA have developed a way to guide AlphaFold with experimental data, enabling the model to better reflect physical and biological reality. This approach aims to improve future predictive models by accounting for structural heterogeneity and dynamism in proteins.
Researchers developed a pH-triggered nanocomposite that synchronizes the release of therapeutic agents, combating bacterial biofilms and oxidative stress. The platform accelerates healing and promotes tissue repair in infected wounds.
A POSTECH research team has created an automated, modular system for assembling reconstituted cell-free systems, significantly reducing costs by 95% and preparation time to 2 days. This innovation enables the customization of individual components, paving the way for improved biologically engineered high-value therapeutics.
The project aims to systematically map how individual pairs of cells influence each other, with the goal of understanding cell-cell communication in health and disease. By characterizing the cellular dyad, scientists can determine which cell influenced which partner, when the interaction began and what changed as a result.
Luis Márquez, a renowned expert in applied plant biology and biotechnology, will lead the UMass Amherst Cranberry Station. He aims to increase cranberry quality and health benefits, leveraging its medicinal food potential.
Researchers developed an injectable hydrogel combining silk proteins and a kudzu plant compound, achieving complete wound closure within 72 hours. The material's mechanical stability and cell viability exceeded expectations.
Researchers designed artificial proteins that simultaneously form pentagonal and hexagonal arrangements to create virus-like structures. These structures can stably carry drugs, genetic materials, and enzymes within their interior space.
Researchers have developed a generative AI model called Void-X that can predict protein-protein interactions with high accuracy, enabling the design of new biomolecules for drug discovery and synthetic biology. The model achieves predictive accuracies of 78.3% for intra-chain clusters and 68.2% for inter-chain clusters.
Terasaki Institute researchers and key pioneers publish comprehensive review on glioma organoid models, proposing a foundational classification framework to guide translational brain tumor research. The review provides an overview of human glioma organoid systems and aims to address methodological heterogeneity in the field.
Old Dominion University has launched a National Security Institute to accelerate research and technology solutions for pressing national security challenges. The institute will bring together researchers' strengths in AI, autonomy, and coastal systems to deliver innovative solutions.
A new study has analyzed over 2100 samples to build a genetic dataset containing more than 500 million unique genes, revealing the immense potential of deep-sea biodiversity for developing new technologies. The research found that despite vast genetic diversity, deep-sea organisms rely on stable, core designs to survive extreme conditi...
Researchers uncover how a previously uncharacterized transporter protein controls magnesium transport in rice, leading to improved grain development, nutritional quality, and cooked texture. The study reveals that magnesium transport is closely linked to crop productivity and sensory traits.
Researchers summarize recent developments in terahertz biophotonics, highlighting its potential for overcoming technical limitations in fields like skin cancer diagnosis, wound assessment, and drug discovery. The study provides a roadmap for future research to improve the field's practical applications.
The center will develop new phage-based treatments for antibiotic-resistant bacterial infections, predicting which phage to use for which patient and designing more effective phages. The goal is to generate unprecedented data and train AI models to identify the right phage for any patient's infection.
Researchers at Tokyo University of Science engineered CYP107J1 enzyme from Bacillus subtilis into a more practical tool for selective oxidation chemistry. The modified enzyme showed 28-fold higher catalytic activity and successfully converted indole into indigo, a commercially important blue dye.
The partnership aims to consolidate and expand scientific partnerships in strategic areas, with a focus on artificial intelligence, biotechnology, and energy transition. FAPESP and UKRI will co-chair the Transatlantic Platform and explore joint research centers to advance this exceptional partnership.
A new five-year field study suggests that pairing annual biochar amendment with water-saving irrigation can reduce methane emissions from paddy fields. Continuous biochar use maintained and strengthened methane mitigation over time, while a one-time application's effect weakened.
Researchers at the University of Toronto have developed a suite of low-cost, portable biotechnology tools to improve access to laboratory research and diagnostics in resource-limited settings. The decentralized biomanufacturing systems enable local production of high-value biological materials, reducing reliance on fragile internationa...
Researchers at Institute of Science Tokyo genetically engineer cyanobacteria to produce sulfated polysaccharides, a sustainable route for manufacturing biomaterials. The study demonstrates the feasibility of engineering complex biosynthetic pathways in photosynthetic organisms.
A new study found that pairing biochar with beneficial Bacillus bacteria can improve phosphorus availability in soil, reshape the root-zone microbial community, and strengthen root architecture. This leads to increased fruit-cluster branching and a 23.53% increase in cherry tomato yield.
A clinical trial is underway at Rice University and Baylor College of Medicine to develop advanced neuroprosthetics for individuals with paralysis. The team is working on decoding cortical neural signals to control robotic assistive devices, enabling people with tetraplegia to eat and drink independently.
A study reveals that TREM2+ macrophages directly recognize candidalysin, a toxin secreted by Candida albicans, to initiate an immune response. This recognition leads to the activation of key immune cells and the production of pro-inflammatory cytokines, ultimately protecting against fungal infection.