Articles tagged with Biotechnology
Researchers at Osaka Metropolitan University engineered yeast to produce 122 times more 2,3-butanediol in high-concentration environments. Gene expression analysis revealed the crucial role of proteasome and peroxisome activation in tolerance.
Researchers discover RFP's role in adipogenesis, a process that forms fat-storing cells. The study found that high RFP levels promote easy fat cell formation and weight gain, while low levels resist weight gain.
Researchers have created a novel synthetic enzyme that efficiently converts CO2 into formic acid, opening up new possibilities for biotechnological production of valuable chemicals and fuels. The enzyme, FAR, tolerates high concentrations of formate and is stable in both living cells and cell-free systems.
Philip R. Troyk, director of the Pritzker Institute of Biomedical Science and Engineering at Illinois Tech, has been elected as a Fellow of the National Academy of Inventors for his groundbreaking work on neuroprosthetic devices, including an implanted cortical visual prosthesis that provides artificial vision to individuals with profo...
Researchers used CRISPR technologies to discover previously unannotated DNA stretches in the 'dark genome', which control cell response to mechanical properties of their environment. This work could lead to new therapeutic targets for illnesses involving changes to tissue mechanics, including fibrosis and cancer.
Researchers at TUM have developed a method to boost oxidase biosensor accuracy from 50% to 99%, paving the way for new uses in personalized medicine, AI-driven healthcare, and agriculture. This breakthrough could enable on-site adjustments to fertilization, reducing environmental impact.
A newly developed wearable sensor uses polarized light to improve photoplethysmography (PPG) signal accuracy across different skin tones. The device splits light into two channels, detecting co-polarized and cross-polarized signals to filter out superficial scattering and capture stronger signals from deeper tissue.
Researchers found that a mitochondrial protein called COX7RP increases healthy lifespan in mice by improving its mitochondrial energy efficiency. The study also showed improved glucose homeostasis, healthier lipid profiles, enhanced muscle endurance, and lower fat accumulation in the liver.
Researchers at ETH Zurich have developed a solution to introduce artificial amino acids into bacteria efficiently. By hijacking a natural transport system, they can produce designer proteins with unnatural amino acids just as efficiently as their natural counterparts. This breakthrough enables the expansion of the 'amino acid toolbox' ...
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
University of Houston engineers have discovered that melatonin helps plants grow by adjusting biological processes to coincide with daily cycles. The hormone also enhances photosynthesis and improves stress tolerance in crops.
Researchers at Case Western Reserve University improved electrode performance in brain-computer interfaces by delivering anti-inflammatory drugs directly to the site of implantation using platelet-inspired nanoparticles. The breakthrough has potential applications for treating various diseases involving inflammation and vascular injury.
Scientists developed a wireless device that uses light to send information directly to the brain, bypassing natural sensory pathways. The soft device delivers precise patterns of light through the bone to activate neurons across the cortex, allowing mice to learn and interpret meaningful signals.
A new advance in EEG imaging technology has improved mapping for epilepsy surgery, providing an accurate and non-invasive method. Pathological HFOs were found to be the most accurate biomarker for identifying epileptogenic brain regions, allowing for precise localization of seizure onset.
Researchers at Emory University uncover how deep-sea microbes create complex structures through a simple process, driving chaperone-free polymerization of archaeal cannulae. This discovery sheds light on the unique adaptations of extremophiles, which thrive in extreme environments.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
Extracellular vesicles can mediate communication between cells and tissues, influencing processes like immune signaling and cancer progression. Researchers have developed a practical, scalable EV-isolation platform that operates without preprocessing steps or specialized equipment.
A research team developed a hydrogel that senses changes in wound pH and responds with antibacterial agents to fight infection. As healing progresses, the gel releases ions supporting angiogenesis and tissue regeneration, achieving over 90% wound closure in just 14 days.
The team created a specialized two-dimensional thin film dielectric designed to replace traditional heat-generating components in integrated circuit chips. This breakthrough aims to reduce the significant energy cost and heat produced by high-performance computing necessary for AI.
Researchers at UBC Okanagan develop an innovative airflow system that captures and removes exhaled aerosols, significantly reducing the probability of infection. The new device outperforms conventional ventilation systems, offering a comfortable and effective solution for indoor spaces.
The Virtual Cell Pharmacology Initiative (VCPI) aims to build the first standardized framework for virtual cell modeling in drug discovery. Ginkgo Datapoints is offering free high-throughput RNA profiling via its platform, generating over 12 billion data points and aiming to test at least 100,000 compounds.
Researchers have developed a gene editing technique that allows for the creation of tumor cells with silenced genes in mice without triggering an immune response. This enables the study of metastasis regulators and potential new targets for cancer therapies.
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
The partnership aims to co-develop and evaluate next-generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza. Apriori's Octavia platform will be combined with A*STAR IDL's saRNA delivery technology to develop improved H5 influenza vaccines that anticipate infection in humans.
A new heart monitoring system featuring dry 3D-printed electrodes and AI software can diagnose up to 10 types of arrhythmias, reducing testing time and medical waste. The system's reusable design improves patient comfort and compliance during long-term monitoring.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Research suggests that health apps, wearables, and interactive programs can improve physical activity, diet, and weight outcomes for children and teens. Mobile apps had the greatest impact on diet and weight outcomes, while wearables were most effective for reducing sedentary time.
A systematic review examines the current landscape in data processing flow, multimodal fusion strategy, and model architecture for affective computing. Deep learning methods are shown to extract feature representations with high consistency across public datasets and self-collected data.
Researchers have made significant advances in genetically modified plants that produce alpha-amylase inhibitor proteins, making them indigestible to pests like bedbugs, beetles, weevils, and woodworms. Gene editing techniques, such as CRISPR, offer a promising solution to combat insect pests without compromising human consumption.
Researchers at Hosei University developed a hydroponic cultivation system using LED lighting to produce high-quality edamame consistently throughout the year. The nutrient film technique (NFT) method resulted in higher yields, better nutritional value, and increased productivity compared to traditional open-field cultivation.
Scientists from Delft University of Technology have developed living materials that can detect disease biomarkers, catalyze environmental pollutant breakdown, and function as self-healing composites. The materials are made by embedding bacterial spores in a protective barrier and can be programmed to perform specific tasks.
A nonsurgical approach has been demonstrated to quiet a specific brain circuit in an animal model by delivering engineered gene therapy only to the targeted region. The method uses low-intensity focused ultrasound to open the blood-brain barrier, allowing precise control over brain activity without impacting off-target areas.
Researchers developed a novel exoskeleton CASIA-EXO with subject-adaptive control, enabling efficient motor relearning and enhancing neural plasticity. The system uses intention-based trajectory planning and performance-based intervention adaptation to individualize training trajectories and intervention levels.
The partnership designates JMIR Bioinformatics and Biotechnology as the official journal of MCBIOS, ensuring high-visibility publication of cutting-edge bioinformatics research. The agreement also provides benefits such as a discount on article processing fees and virtual education and training for MCBIOS members.
Scientists at Southwest Research Institute (SwRI) have successfully replicated induced Pluripotent Stem Cells (iPSCs) using a new application of their cell-expansion bioreactor. The bioreactor's unique geometry allows for the growth of large quantities of iPSCs, which can differentiate into any other cell type in the body.
Computationally predicted protein target sites offer a strategic pathway for disease mechanism elucidation and therapeutic acceleration. Advanced frameworks like Markov State Models and Gaussian accelerated MD enable exploration of long-timescale dynamics.
Genetic engineers design gene circuits to program cells with new functions, but dilution causes loss of function. Researchers use liquid-liquid phase separation to form transcriptional condensates around genes, protecting genetic programs and maintaining stability across cell generations.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
The BioHub aims to complete over 24 pilot projects, train over 500 individuals, and create 3,000 new jobs within three years. Powered by breakthroughs in genetics, genomics, process engineering, and artificial intelligence, Central Massachusetts is poised to lead a new era of biology-based manufacturing.
Binghamton University scientists have developed a novel bioelectronics material that combines living liquid metal with electrogens to create next-generation devices. This innovation has the potential to revolutionize fields such as biomedical sensing and device integration.
Researchers have identified iron-manganese alloys as promising candidates for temporary bone fixation. These alloys combine strength, biocompatibility, and degradation properties, allowing them to support bone healing while degrading naturally. However, challenges remain, including controlling the release of manganese, which can pose t...
Advanced molecular dynamics simulations model complex RNA structures with high accuracy, enabling potential applications in RNA-based therapies and drug design. The study successfully simulated the folding of diverse RNA stem loops, revealing a distinct folding pathway for challenging motifs.
Dr. Xin Jin has been recognized for her groundbreaking work on genetic mechanisms of neurodevelopmental disorders, developing new technologies to accelerate the understanding of gene mutations in the brain. Her research aims to uncover fundamental principles of genome function and its impact on neural systems.
A team of scientists has successfully developed a new method for producing large amounts of xanthommatin pigment in the lab, using a nature-inspired approach. This breakthrough could lead to the creation of camouflage-inspired materials and cosmetics, as well as alternative materials for industries moving away from fossil fuels.
Researchers have successfully produced high-performance fibers from fermentation waste, offering a sustainable alternative to traditional materials. The new fiber requires significantly less water and land than cotton, making it an attractive solution for reducing the environmental impact of the fashion industry.
Researchers at ETH Zurich have successfully produced muscle tissue using a new biofabrication system called G-FLight in microgravity. The process enables rapid production of viable muscle constructs with similar cell viability and muscle fibers as those printed under gravity.
Australian researchers have developed tiny compartments to help supercharge photosynthesis, enabling plants to fix carbon more efficiently. The team engineered encapsulins that can house the enzyme Rubisco in a confined space, allowing for fine-tuning of compatibility for future use in crops.
A breakthrough gene atlas for oats has been developed, which could help plant breeders create better oat varieties with improved health benefits and climate resistance. The atlas will significantly expand genomic resources available to researchers.
A team of biomechanical engineers and surgeons has developed a 3D-printing soft robot that can accurately deliver hydrogels to the vocal cord surgical site. The device, which is only 2.7 mm in size, can reconstruct tissues removed during surgery and potentially prevent fibrosis and stiffening of the vocal cords.
Researchers at the University of São Paulo developed a low-cost, portable biosensor that can quickly identify altered levels of BDNF associated with psychiatric disorders. The device detects extremely low concentrations of BDNF in human saliva, which is crucial for growth and maintenance of neurons and development of brain functions.
A new study suggests that collecting and testing cancer cells in patients' blood could help doctors choose the right breast cancer treatment. The 'labyrinth chip' technology separates cancer cells from other blood cells, allowing researchers to identify biomarkers that distinguish aggressive treatments from less invasive ones.
The partnership creates a stable, high-impact venue for MCBIOS members to publish their research, particularly the output from the Society's annual conference. The designation of JMIR Bioinformatics and Biotechnology as the official journal provides maximum visibility for cutting-edge work in bioinformatics and computational biology.
A team of Pitt engineers has created self-powered spinal implant technology capable of transmitting real-time data from inside the body. The innovation utilizes new human-developed composites known as metamaterials to harvest energy and transmit signals wirelessly.
Researchers from The University of Osaka and The University of Tokyo have developed a novel technology that visualizes specific molecules inside living cells using light. The new photo-responsive alkyne tag enables precise visualization without disrupting molecular dynamics.
Researchers have developed biochar-supported microbial systems to tackle persistent organic pollutants, including polycyclic aromatic hydrocarbons and pesticides. These integrated strategies have achieved impressive results, breaking down pollutants in industrial wastewater, agricultural soils, and domestic environments.
Researchers at UC San Diego have discovered a new way to make yeast cells more efficient 'cell factories' for producing valuable plant compounds. The advance enables the sustainable manufacturing of plant-derived chemicals used to help plants defend against disease, repel pests, attract pollinators, and withstand environmental stresses.
The Stowers Institute has appointed its first AI Fellow, Sumner Magruder, to harness the potential of artificial intelligence in biological research. He will collaborate with researchers to design new algorithms and unlock insights from large datasets.
Researchers at the University of Texas at Austin have developed a novel gene-editing method that can correct multiple disease-causing mutations simultaneously. This approach uses bacterial retrons to protect the microbes from viral infection and has shown promising results in correcting scoliosis-causing mutations in zebrafish embryos.
The Science/Science Careers' 2025 Top Employers Survey ranked the top companies in biotechnology, biopharmaceuticals, and pharmaceuticals based on employee responses. The survey found that companies with strong reputations as employers prioritized innovation, leadership, and work culture.
A Moroccan ICU study shows that the plethysmographic perfusion index can help identify fluid responsiveness in critically ill patients with acute circulatory failure non-invasively. Two-thirds of patients were fluid responders, and PPI correctly identified responders with 70% sensitivity and 82% specificity.