Articles tagged with Biotechnology
Research in SLAS Technology Vol. 40 explores smartphone glucose sensing and RNA-based therapeutics in Crohn's disease. The publication showcases innovative technologies and scientific advancements in life sciences discovery and development.
SLAS Discovery highlights innovative screening platforms and AI-driven analytics for treating oncology, infectious disease, and immunology research. The journal focuses on drug discovery sciences with a strong record of scientific rigor and impact, reporting on research that advances life sciences discovery and technology.
A new paper-thin robot powered by muscle cells can swim through a watery maze, offering a way to design small, efficient biohybrid robots. The robot uses a layer of live muscle cells that twitch in response to light, allowing it to control its direction and speed.
Researchers from Shibaura Institute of Technology used molecular simulations to investigate how an enzyme's shape affects molecular recognition and ligand retention. They found that enzyme shape influences ligand retention, with 75.6% of trajectories in the closed group retaining ligands compared to 55.1% in the open group.
Researchers have developed a laser-powered technology that accelerates antibody-antigen interactions to detect tiny amounts of a colorectal cancer biomarker within minutes. This technology has the potential to improve cancer diagnosis by increasing detection sensitivity and speed.
A new review in Microbiome and One Health examines China's microecology development and its contribution to the global One Health approach. The field has expanded to human health, agriculture, environmental restoration, and traditional Chinese medicine, with emerging tools like AI, multi-omics, and synthetic biology.
Researchers at MIT have developed a handheld device to collect living cells from specific locations in patient samples, enabling early cancer detection and personalized medicine development. The device uses a microfluidic channel to gently detach living cells from tissue, allowing for targeted sampling and cultivation for diagnostics a...
Researchers developed a soft, reusable smart contact lens that measures serotonin levels in tears, shedding light on stress-related physiological changes. The device, part of a broader tear bioelectronics platform, detects serotonin at low concentrations, enabling the tracking of small changes in stress levels.
Hot peppers grown in biochar and animal manure-amended soil exhibit higher heavy metal concentrations, particularly Zn and Cu. Bioaccumulation factors for certain metals exceed 1, indicating potential for remediation.
A three-herb preparation restored immune function in rats exposed to simulated weightlessness and challenged with bacteria, suggesting a nutritional way to help crew health on long-duration missions. The study also highlights the potential for the formula to support individuals on the ground who experience similar immune declines.
A study led by Göttingen University found that ethephon can delay flowering in sweet cherry varieties, potentially protecting them from frost damage. However, the treatment was not consistent across all varieties and regions, highlighting the need for further trials.
A team of researchers has developed nanoparticles that can activate nerve cells in degenerated retinas, potentially leading to a new type of retinal prosthesis. The nanoparticles, made from graphitic carbon nitride, trigger electrical and chemical processes that activate nerve cells and prompt signals towards the brain.
Researchers at MIT created a new computing platform that mimics the firing behavior of a neuron, enabling brain-inspired computing with low power and high efficiency. The device uses reconfigurable motion to remember and process information, similar to how neurons behave in the brain.
Researchers at Tulane University have developed a diagnostic platform that can identify the precise species of bacteria causing NTM lung disease infections within four hours. The platform, called CANDI, uses mucus from the lungs and other respiratory fluids to test for up to 15 clinically relevant species and subspecies of NTM bacteria.
Researchers have made breakthroughs in deleting yeast DNA using CRISPR, with potential to save lives from fatal candidiasis infections. The team is expanding the technology to diverse fungi and using AI models to predict its success.
Scientists have created the first global atlas of single-cell microbes living in the aphotic ocean, revealing unexpected functions and capabilities among deep-sea microorganisms. The new database, GORG-Dark, contains over 9,600 genomes from individual microbial cells collected across a broad range of depths and locations.
A Korea University study found that an mRNA-based influenza vaccine elicits a more diverse and broader serum antibody repertoire than traditional vaccines. This leads to greater binding and neutralizing breadth against diverse influenza strains, suggesting potential for broader, longer-lasting protection.
A novel laser-fabricated plasmonic chip combines 185 nm Raman resolution with deep learning to identify and sort cancer cells. The developed sorter achieves precise cell sorting without labeling, using spatially resolved Raman signals.
A team from Helmholtz Munich developed MemBrain v2, an AI tool that automates the analysis of cell membranes in 3D images, cutting work from weeks to hours. The tool locates specific membrane proteins and analyzes their spatial arrangement, showing how cellular processes are organized at the molecular level.
Researchers have developed the AlphaGenome Atlas, a comprehensive map of more than 9 billion possible single-letter DNA changes. The one-petabyte dataset provides artificial intelligence-generated predictions for the molecular effects of these changes, accelerating understanding of the human genome.
A new framework predicts AIE behavior using quantum chemical calculations, identifying key structural factors that control excited-state dynamics. The framework enables rational design of luminescent AIE materials for applications like OLEDs, bioimaging, and sensors.
Researchers at Ritsumeikan University discovered a bacterial selenoprotein that uses a unique selenium–sulfur–heme catalytic center to reduce polysulfides during elemental sulfur respiration. The enzyme, MccSep, is crucial for understanding the sulfur cycle and has implications for environmental monitoring and biocatalyst development.
A KAIST-developed micro-LED mask boosts skin rejuvenation and brightening through close skin contact, while PN injections provide synergistic benefits for skin regeneration and recovery. The mask achieves 340% greater improvement in deep skin elasticity than conventional LED masks.
scLS detects pseudotime-associated genes without explicit regression models, suitable for irregularly distributed data and complex cell trajectories. It offers a computationally efficient approach for downstream trajectory analysis, identifying dynamic and shifted gene expression patterns.
FAU will investigate how undergraduate STEM education can better connect scientific discovery with workforce preparation, leveraging industry partnerships and research infrastructure. The project aims to strengthen students' technical and professional skills, scientific problem-solving, and career confidence.
Pharmaceutical contamination in soil and air has severe ecological impacts, affecting animal, plant, and microbial communities. The review highlights the need for interdisciplinary research to understand the dynamics of pharmaceuticals in soil and their long-term implications for ecosystem health.
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
A research team at the Wyss Institute has engineered bacteria to produce higher amounts of siderophores, molecules that extract iron from silicate minerals, speeding up rock weathering and removing CO2 from the atmosphere. This process has the potential to be implemented at industrial scales, offering a new climate-regulating strategy.
Researchers at Ritsumeikan University developed a unique 'cut-to-fuse' strategy for molecular skeletal editing, transforming hydroxycoumarins into coumaranones under mild conditions. The method, published in JACS Au, demonstrates a new route to molecular scaffold construction, offering a valuable tool for medicinal chemistry.
Researchers at China Agricultural University have developed two novel Type I-C CRISPR systems, Aca I-C and Cja I-C, for efficient genome editing in maize. These systems enable targeted large-fragment deletion and expanded-window base editing, highlighting their potential for crop trait improvement.
Researchers discovered Stutzerimonas nitrititolerans bacteria in geese feces in China carrying carbapenem and tigecycline resistance genes. The bacteria showed high resistance to meropenem and reduced susceptibility to tigecycline. Genome sequencing revealed two distinct resistance-associated regions, one carrying bla PST-2 and the oth...
USC researchers have developed custom, 3D-printed MRI sensors that provide clearer images of small organs in infants and children. The sensors, which can be customized to individual patients, are made in under 10 minutes and cost around $30.
A joint team from NJU and PKU achieves single-shot high-fidelity lensless dynamic imaging by merging physical modeling with neural representation. This approach enables the recovery of clear and high-resolution images of moving samples, paving the way for flexible and practical lensless imaging applications.
A new study suggests that zinc oxide nanoparticles can improve key agronomic, nutritional and quality traits in direct-seeded rice, including increased zinc concentration, spikelets per panicle and 1000-grain weight, and reduced amylose content and chalkiness.
A new smartphone app called Mobilio uses AI, machine learning, and personalized audio cues to provide turn-by-turn directions, path guidance, and obstacle avoidance for people with blindness or low vision. The app completed outdoor navigation tasks 13% faster and reduced obstacle contact by 41% compared to Google Maps and a white cane.
A team from Osaka Metropolitan University created a coconut oil-based fuel that can be added to jet fuel without lowering performance. The fuel blend showed comparable thermal efficiency and reduced hydrocarbon emissions, making it a promising alternative.
Hiroshima University researchers demonstrate that food processing liquid waste can be reused to produce omega-3 fatty acids by cultivating Aurantiochytrium sp. The study shows that three types of pickle seasoning waste can be utilized by the thraustochytrid to produce DHA and EPA. Reusing the waste medium also produces DHA and EPA, but...
Researchers from Institute of Science Tokyo and Kyoto University created hierarchical DNA networks using DNA polymerase and kinesin nanomachines. The study demonstrates the importance of active molecular motion in network formation, a step toward materials that assemble and organize themselves like living systems.
Researchers at Hiroshima University found that changing the carbon source for bacterial fermentation produces high-value biomaterials with promising biomedical and industrial applications. The study shows that sugarcane molasses produces EPSs with superior antioxidant and antibacterial activities.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Researchers examine recent progress in chitosan-alginate composite beads for sustainable wastewater treatment, highlighting their potential as cost-effective and reusable solutions. The study also explores future applications of these biopolymer composites in precision medicine, smart agriculture, and the circular bioeconomy.
Researchers at Dongguk University have developed an innovative gene switch that uses electromagnetic fields to control gene expression. The switch, which targets the Lgr4 gene, demonstrates precise activation with no detectable adverse effects, making it a promising platform for non-invasive gene therapies.
A study from Institute of Science Tokyo reveals how histone variants direct DNA methylation to jumping genes, preventing accidental gene silencing in plants. This molecular framework enables plant cells to distinguish transposons from genes, ensuring precise epigenetic regulation across the genome.
Researchers developed a flexible microsystem to deliver light directly to internal cancer treatment sites, overcoming the limitation of traditional PDT. The system, powered wirelessly and containing tiny light-emitting components, shows promising results in laboratory tests, paving the way for more precise and effective cancer treatments.
Researchers explore bacterial extracellular vesicles as a tool for cancer diagnosis and treatment, with potential for targeted delivery of therapeutic molecules and immunotherapy. However, consistency and safety remain major challenges in this emerging field.
The new integrations provide enterprise AI agents direct access to live, structured research data from Dimensions' 430M+ interconnected records. This allows for AI-assisted analytics across one of the world's most comprehensive linked views of global research activity.
Scientists created a platform that pinpoints genetic triggers for microbes to produce new chemicals and materials. The method enables rapid, precise reprogramming of bacteria as biotechnology tools, supporting the domestic production of valuable products.
The University of Tennessee is expanding its research excellence with the addition of eight exceptional researchers, tackling pressing challenges in fields like precision health, advanced computing, and sustainable materials. The new faculty members bring expertise that builds on the university's strengths and solidifies its standing a...
Lehigh University researchers develop comprehensive mathematical model of the neural circuitry linking the gut and brain to regulate stomach function, opening new pathways for treating chronic digestive disorders through targeted vagus nerve stimulation. The digital twin could help accelerate therapy development and improve quality of ...
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Wearable sensors can track dynamic changes in uric acid levels, providing valuable information for assessing healing progress and adjusting treatment plans. Researchers have improved the accuracy and reliability of these sensors using new materials and technologies.
Scientists from the University of Osaka created an autonomous solid-state nanopore that can sense molecules, generate electrical signals, and retain memories of recent events. The device continuously changes its structure through chemical reactions, creating a dynamic sensing environment that responds to molecules passing through it.
A new wearable sticker system has been developed to simplify diagnostic sweat testing for cystic fibrosis, a genetic disorder affecting digestion and breathing. The innovative technology is reliably accurate and makes the test more accessible beyond specialized centers.
Researchers found perilla oil supplementation significantly prolonged platelet function and reduced inflammation in healthy smokers. The study also showed increased levels of omega-3 fatty acids and antioxidants in the body.
Researchers at the University of Manchester have developed a new family of antifungal agents that are more potent and less toxic than existing treatments. The compounds, which were discovered through genome mining, showed increased antifungal activity and improved solubility compared to existing drugs.
Researchers have developed an oxidation-free approach to oligonucleotide synthesis using P(V)-fluoridates, enabling rapid coupling and automated synthesis. The new platform offers improved efficiency and stability compared to conventional methods.
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
Researchers identify AXL as a previously unrecognized regulator of bone formation, promoting osteoblast maturation and increasing bone mass. Inhibiting Axl using BGB324 increases bone growth in mice without significant toxicity.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers developed a soft, stretchable antenna that can maintain stable wireless connections even during movement. The antenna's design allows it to compensate for changes in shape and size, enabling wearable devices to track vital signs continuously and reliably.