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Researchers make major strides toward an all-purpose biosensor chip

The researchers have demonstrated significant improvements for chip-based sensing devices that can detect or analyze substances across widely varying concentrations. They developed signal-processing techniques that enable seamless fluorescence detection of a mixture of nanobeads in concentrations across eight orders of magnitude.

SourceOptica·JournalOptica·DateJun 22, 2023

Antibody alternatives for biosensing

Researchers developed an electronic biosensor using DNA aptamers to detect biomarkers in whole blood samples. The biosensor successfully detected clinically relevant levels of a marker protein for cardiovascular disease without further sample preparation.

SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateApr 18, 2023

Mind-control robots a reality

The University of Technology Sydney has developed a brain-computer interface technology that allows users to control devices such as robots and machines using only their thoughts. The technology has been successfully tested in various environments, achieving high accuracy rates of up to 94%. It also has significant potential in fields ...

SourceUniversity of Technology Sydney·JournalACS Applied Nano Materials·TypeExperimental study·DateMar 19, 2023

Pusan National University develops novel biosensor to detect DNA damage in real time

Researchers at Pusan National University have developed a novel FRET-based biosensor to detect double-strand breaks in DNA, providing real-time information on γH2AX. The sensor's sensitivity is higher than conventional immunostaining techniques, making it useful for identifying DNA damage factors and elucidating repair mechanisms.

SourcePusan National University·JournalBiomaterials Research·TypeExperimental study·DateMar 13, 2023

Fiber sensing scientists invent 3D printed fiber microprobe for measuring in vivo biomechanical properties of tissue and even single cell

Researchers at Shenzhen University have developed a compact fiber optical nanomechanical probe (FONP) to measure in vivo biomechanical properties of tissue and even single cells. The high-precision mechanical sensing system enables accurate measurements with spring constants as low as 2.1 nanonewtons.

SourceInternational Journal of Extreme Manufacturing·JournalInternational Journal of Extreme Manufacturing·DateFeb 10, 2023

Biosensor could lead to new drugs, sensory organs on a chip

A synthetic biosensor created at Cornell University enables the study of proteins in ways previously impossible, leading to potential applications in drug development and environmental sensing. The system uses cell-free synthesis to produce proteins directly into an artificial membrane, allowing for dual optical and electronic readouts.

SourceCornell University·JournalSynthetic Biology·DateFeb 7, 2023

INCIDER fluorescent sensors visualize sticky situations

Researchers from Osaka University developed a new fluorescent sensor system to visualize N-cadherin-mediated interactions between living cells. The INCIDER system enables accurate tracking of temporal changes in these interactions, with a fluorescence signal 70 times stronger than existing methods.

SourceOsaka University·JournalCommunications Biology·TypeImaging analysis·DateDec 15, 2022

Plants can measure the intensity of salt stress

Researchers at the University of Münster have identified a specific group of cells in plant roots that react to salt stress, forming a 'sodium-sensing niche' and triggering a calcium signal. This signal is controlled by a calcium-binding protein (CBL8) that helps pump out salt from the plant under severe stress conditions.

SourceUniversity of Münster·JournalDevelopmental Cell·TypeExperimental study·DateAug 25, 2022

UMass Amherst researchers pioneer nanoelectronic sensor that simultaneously measures electrical and mechanical activity in heart cells

Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.

SourceUniversity of Massachusetts Amherst·JournalScience Advances·TypeExperimental study·DateAug 24, 2022

Researchers recycle CDs into flexible biosensors

Binghamton University researchers have developed a way to turn CDs into flexible biosensors that can monitor electrical activity in human hearts and muscles, as well as lactate, glucose, pH, and oxygen levels. The sensors are fabricated in 20-30 minutes without toxic chemicals or expensive equipment, costing around $1.50 per device.

SourceBinghamton University·JournalNature Communications·DateJul 26, 2022

Fast, efficient COVID-19 biosensor under development

Researchers from Indiana University are developing a new biosensor that can analyze samples from 96 individuals in under three hours, with a sensitivity rate of 100% and specificity rate of 90%. The sensor detects not only the virus's spike protein but also the proteins created by the body to protect against the virus.

SourceIndiana University·JournalACS Applied Materials & Interfaces·DateJul 21, 2022

UMass Amherst researcher uses graphene for same-time, same-position biomolecule isolation and sensing

New research by UMass Amherst professor Jinglei Ping demonstrates the use of graphene for electrokinetic biosample processing and analysis, allowing for faster and more efficient detection of biomolecules. This breakthrough enables the creation of smaller lab-on-a-chip devices with improved time and size efficiencies.

SourceUniversity of Massachusetts Amherst·JournalACS Nano·TypeExperimental study·DateJul 18, 2022

NYU Abu Dhabi researchers develop new tool that brings missing sense of touch to minimally-invasive surgery procedures

Researchers from NYU Abu Dhabi have developed a simple yet effective approach for on-demand tactile sensing in minimally-invasive surgery. The Smart Laparoscopic Forceps (SLF) system measures grasping force and angle, providing surgeons with relative stiffness index of tissue to help with decision-making during operations.

SourceNew York University·JournalIEEE Journal of Translational Engineering in Health and Medicine·DateJun 23, 2022

Reliable diagnostics at the tip of your finger

Researchers developed a biosensor using nanostructured and nanoporous surfaces to detect biomarkers in clinical samples, overcoming technical challenges of small sample amounts. The new technology can provide quick and accurate diagnoses for diseases like prostate cancer without needing dilution or preprocessing steps.

SourceInstitute for Basic Science·JournalAdvanced Materials·TypeExperimental study·DateMay 17, 2022

Multi-tasking wearable continuously monitors glucose, alcohol, and lactate

A new wearable device can simultaneously monitor glucose, alcohol, and lactate levels, providing users with a comprehensive picture of their health. This technology has the potential to improve disease management for individuals with diabetes and other conditions, as well as enhance overall wellness through real-time tracking.

SourceUniversity of California - San Diego·JournalNature Biomedical Engineering·DateMay 9, 2022

With a whiff ‘e-nose’ can sense fine whisky

A new e-nose prototype, NOS.E, can distinguish between six whiskies by brand names, regions, and styles in under four minutes, with 100% accuracy for region detection and 96.15% for brand name identification. The technology has applications beyond whisky, including counterfeiting detection in perfume and wine.

SourceUniversity of Technology Sydney·JournalIEEE Sensors Journal·TypeExperimental study·DateApr 5, 2022

Living sensor research wins federal backing

The five-year grant aims to develop electrobiology techniques that enable applications like living sensors to quickly detect environmental pollutants. The project will involve multiple disciplines, including synthetic biology, protein engineering, soft materials, microsystems integration, and machine learning.

Development of semiconductor microchip that can detect prostate cancer markers with ultra-high sensitivity

Researchers at Toyohashi University of Technology developed a microchip capable of detecting ultra-low concentrations of prostate cancer antigens using flexible nanosheets. The chip's lower detection limit is comparable to that of large testing devices, enabling fast and accurate diagnosis.

SourceToyohashi University of Technology (TUT)·JournalSensors·TypeExperimental study·DateMar 3, 2022

Sensor monitors disease severity

Scientists at Hokkaido University developed a prototype sensor to rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples. The sensor's sensitivity allows for the accurate detection of these molecules, enabling rapid assessment of disease severity.

SourceHokkaido University·JournalBiosensors and Bioelectronics·TypeExperimental study·DateFeb 25, 2022

(Bio)sensing protein interactions

The study reveals new details about the conditions under which WDR5 starts and stops interacting with other proteins, allowing researchers to better understand its multitasking role in cancer. The biosensor's ability to recognize different types of protein connections will help develop more effective drugs to target WDR5.

SourceSyracuse University·JournalNature Communications·DateFeb 23, 2022

Illuminating real-time brain dynamics of neuropeptides with a fluorescent biosensor

Scientists have developed a genetically encoded biosensor called OxLight1, which enables them to study the action and release mechanisms of neuropeptides like orexin in living mice. The researchers found that the level of orexin release correlates with neuronal activity, revealing previously invisible aspects of healthy brain function.

SourceUniversity of Zurich·JournalNature Methods·TypeObservational study·DateFeb 10, 2022

Scientists test promising biosensor aimed for use in brain

Researchers developed a waterproof biosensor that can accurately detect changes in potassium and sodium ion levels important in TBI. The chip features electronic components that produce an electrical signal when sensing chemicals, and the team successfully tested it in artificial cerebrospinal fluid and human blood serum.

SourceOhio State University·JournalSmall·TypeExperimental study·DateFeb 3, 2022