Articles tagged with Microfluidics
Researchers developed a label-free platform combining microfluidic cell sorting with AI to enrich and identify rare CTCs. The integrated strategy uses inertial microfluidic enrichment and YOLOv8-based deep learning for bright-field image recognition, achieving 96.0% accuracy in distinguishing tumor cells.
A review in Biomedical Analysis highlights the integration of microfluidic technologies to bring flow cytometry closer to point-of-care testing, enabling blood cell counting, leukocyte differential analysis, and imaging-based white blood cell classification
Scientists developed laser-carved microvalves to protect fragile brain catheters from backflow, enabling smooth delivery of therapies. The valves regulate fluid flow through geometry without moving parts, suppressing reverse pressure surges by up to 82%.
A novel laser-fabricated plasmonic chip combines 185 nm Raman resolution with deep learning to identify and sort cancer cells. The developed sorter achieves precise cell sorting without labeling, using spatially resolved Raman signals.
Researchers developed a portable AI-assisted microfluidic platform to detect sub-resistant bacteria, combining machine learning with the ancient 'six-four water diversion' principle. The platform provides a more refined view of bacterial drug response and can identify sub-resistant populations that conventional tests may overlook.
Researchers at Tohoku University have developed a new method for creating efficient micromixers inside polymer fibers, enabling rapid mixing of minute amounts of liquid. The twisted microchannels fabricated using this method promote mixing even at low Reynolds numbers, making it suitable for various applications.
Researchers create engineered extracellular vesicles from red blood cell lipids, evading immune cells and targeting cancer cells. The technology offers flexibility in cargo loading and packaging, enabling delivery of genetic material, proteins, and whole viruses.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
A UVA engineer is developing microfluidic devices and AI-powered computational tools to isolate and study rare circulating cells, which could lead to better treatments for diseases like cancer and infection. The technology aims to integrate with electronics and systems to measure single-cell physical properties on a microchip.
MIT researchers have developed low-cost, 3D-printed triaxial electrospray emitters that efficiently produce three-layered particles at scale. The devices can be used to manufacture time-release drug-delivery nanoparticles with potential applications in biosensors and tissue regeneration.
A new vertical design separates expensive electronic components from disposable plastic patches, allowing sweat to travel upward and make electrical contact with sensors. This separation prevents waste and makes continuous monitoring economically possible.
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
Researchers developed a microfluidic platform that squeezes individual breast epithelial cells to measure their mechanical age, revealing an unexpected insight: older cells are stiffer and at higher risk of cancer. The AI-powered platform provides a non-genetic test for women with unknown genetic risks.
A compact chip holder with integrated electrodes enables temperature control, electric actuation, pressure handling, and optical readout for nanofluidic systems. The platform supports studies on molecular transport, catalytic reactions, and protein aggregation in confined environments.
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
A new study finds hitchhiking bacteria dissolve essential ballast in ubiquitous
Researchers developed a dedicated microfluidics system to overcome limitations of existing methods in multiplexed super-resolution microscopy. The new platform precisely injects and removes solutions, allowing for high-quality imaging of proteins, specialized structures, and complex interactions within cells.
Researchers discovered that highly 'stiff' red blood cells play a crucial role in sickle cell disease, causing blockages and pain. The study's findings could lead to more effective, personalized therapies and new testing for early warning of symptoms.
Researchers develop optoelectrowetting-based system for ultra-precise microdroplets, achieving high volume consistency and reproducibility. The system uses programmable light patterns to control droplet formation, eliminating random pinch-off and improving accuracy.
Researchers at Materials Nanoarchitectonics (MANA) propose a novel strategy for controlling tiny droplets on surfaces, reducing friction and enabling precise control. The study demonstrates that particle-coated droplets can move with reduced force, opening new avenues in micro-scale systems and applications.
A new microfluidic chip combines digital droplet control with built-in 3D microstructures to enable cells to self-assemble into tissue-like clusters. The platform overcomes limitations of traditional two-dimensional cultures and existing microfluidic systems, offering a streamlined approach to 3D cell culture.
Researchers discovered that certain bacteria wrap their rotating flagella around their cell bodies to form a screw thread, allowing them to propel forward through narrow passages. This mechanism enables bacteria to navigate complex environments and even infect host insects.
Researchers developed a new diagnostic chip that can detect tumor cells in blood, allowing for real-time monitoring of brain cancer treatment effectiveness. The GlioExoChip uses extracellular vesicles to assess treatment response, providing a quick and minimally invasive way to inform doctors about chemotherapy efficacy.
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
Researchers at University of Illinois Chicago have developed a microfluidic device that can isolate pancreatic cancer cells from blood samples with high accuracy. The lidocaine infusion method has shown promise in reducing the aggressiveness of circulating tumor cells and may help lower the risk of metastasis.
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
Researchers developed a novel label-free biosensing platform to monitor cellular secretion of monoclonal antibodies in real-time. This approach enables rapid clone selection and cost-effective manufacturing of life-saving immunotherapies.
Researchers developed a palm-sized, portable multimaterial printer using electrowetting on dielectric technology to print conductive and insulating liquids. The printer allows for on-site fabrication of origami devices with customizable shapes and functions, enabling site-specific sensor deployment in resource-limited environments.
A joint team from The University of Osaka revealed that soft particles exhibit unique focusing patterns compared to rigid particles, influencing their focusing behavior. The study provides fundamental insights into the underlying physics, offering a new theoretical model explaining particle behavior under various flow regimes.
Researchers at DGIST developed an implantable wireless neural interface capable of delivering drugs precisely to deep brain regions without external equipment. The device's micro-pump and microchannel structure enable precise drug infusion, overcoming the blood-brain barrier's limitations.
Scientists discovered that human melanoma cancer cells behave like stem cells when forced through channels narrower than 10 micrometres, gaining traits to survive, spread, and form new tumours. Researchers created a biomedical device to simulate blood flow through narrow blood vessels, showing the mechanical pressure makes cancer cells...
A novel electrochemical microfluidic workstation detects additive concentrations in acidic copper plating solution with average relative errors below 10%. The system reduces single-test solution consumption to 220 microliters, enabling online monitoring of process stability and reliability.
Scientists from Institute of Science Tokyo create photo-switchable binding of DNA nanostructures that generate two distinct directional motions. The research paves the way for innovative fluid-based diagnostic chips and molecular computers.
A new microfluidic device promises to revolutionize kidney disease screening by enabling rapid, accurate, and low-cost testing of creatinine levels in urine. The uCR-Chip delivers clinically relevant results within 7 minutes and meets the sensitivity standards of existing point-of-care tests.
Researchers at Nagoya University developed an interface that creates programmable electric fields to sort graphene oxide without fixed microfluidic devices. The findings allow precise sorting of GO sheets, which can capture pollutants, solvents, and biomolecules based on their size-dependent properties.
Researchers are developing a cutting-edge blood test that can accurately track clot formation and breakdown. This innovative approach has the potential to improve patient treatment and reduce complications associated with current treatments.
Researchers from Tokyo Metropolitan University solved the drainage mystery in foams by discovering the pressure needed to rearrange bubbles sets the limit for liquid to drain out. The team found that dynamics play a crucial role in understanding soft materials and designing better foam products.
Researchers developed collagen-based scaffolds that can integrate with a vascular and perfusion organ-on-a-chip reactor to form complete tissue engineering platforms. The team demonstrated the ability to create non-planar 3D networks in soft, organic material by printing helical vascular networks modeled after DNA structure.
A new microfluidic chip design enabled precise control over interstitial flow and shear stress distribution, leading to sustained microvascular growth for over 12 days. The study found that rectangle chambers exhibited the highest network density due to uniform low shear stress, mimicking physiological capillary conditions.
Researchers at Carnegie Mellon University have developed a novel FRESH bioprinting technique that enables the creation of microphysiologic systems entirely out of collagen, cells, and other proteins. This advancement expands the capabilities of studying disease and building tissues for therapy, such as Type 1 diabetes.
A smart bandage called iCares has been developed to monitor chronic wounds in human patients, detecting biomarkers of inflammation and infection. The bandage can provide real-time data and deliver treatment, accelerating the healing process.
A new version of Caltech's smart bandage, iCares, has been shown to continually sample fluid from human patients with chronic wounds, providing real-time data on biomarkers present. The bandage can detect molecules such as nitric oxide and hydrogen peroxide, potentially up to three days before symptoms appear.
The companies have created a microfluidic device-based LNP production system that enables precise control over particle size, addressing previous productivity issues. The system can produce various types of LNPs in small-batch or mass quantities, from personalized medicine to vaccines for infectious diseases.
Researchers from The University of Tokyo developed a novel water-cooling system with three-dimensional microfluidic channel structures to enhance heat transfer. The new design achieved a significant increase in performance, reaching up to 10^5 COP, surpassing conventional cooling techniques.
A study presents a versatile electrodynamics simulation model to analyze driving forces in partially filled electrodes, optimizing structural parameters of digital microfluidic chips. The model reveals the effects of dielectric layer parameters, droplet electrical properties, and substrate spacing on droplet driving performance.
Researchers developed a microfluidic device to alleviate limitations of conventional blood-filtering machines used in treating hyperleukocytosis in children. The new device separates blood cells by size without platelet loss or adverse effects, enabling safe leukapheresis procedures.
A new study using a microfluidic device found that certain infections may not be as resistant to antibiotics as previously thought. The researchers tested three different antibiotic agents against Pseudomonas aeruginosa and found a gradient of antibiotic activity dependent on the flow rate.
Researchers at TIFR Hyderabad developed a novel porous thin-film approach to enhance catalysis efficiency in industrial reactions. The new methodology increases the density of catalytic sites and improves reactant diffusion rates, resulting in higher turnover frequencies and reaction efficiency.
Researchers at TIFR Hyderabad have developed a novel porous thin-film approach to enhance reaction efficiency in catalytic reactions. The new methodology integrates a porous heterogeneous thin film in a cross-flow microfluidic setup, allowing for faster reaction rates and increased catalyst reusability.
The Rice team created a low-cost, pump-free flow cytometer that uses gravity-driven slug flow to analyze cells with similar accuracy as conventional devices. The device is powered by AI and can count specific immune cells from unpurified blood samples within minutes.
Ebru Demir aims to study how groups of AI-driven microswimmers move in biological fluids for potential applications in drug delivery, fertility treatments, and other medical fields. Her research combines artificial microswimmers with machine learning to uncover the underlying physics governing their movement.
Researchers at NC State University have developed a new technique to tune the optical properties of quantum dots using light, reducing energy consumption and environmental impact. This method allows for precise control over the bandgap, enabling the creation of high-quality perovskite quantum dots for optoelectronic devices.
A new droplet microfluidic component library utilizes micromilling technique to produce devices at a fraction of the cost of traditional methods. The library includes versatile components for complex workflows, enabling high-throughput applications in biological and chemical research.
Researchers from Aalto University have created a synthetic surface inspired by lotus leaves and found that plastronic waves travel along the surface at speeds up to 45 times faster than capillary waves. The discovery could lead to new applications in biotechnology, materials science, and pharmaceuticals.
A novel lab-on-chip platform uses acoustofluidics to efficiently separate rare circulating tumor cells, enabling real-time diagnosis. The system's precision and energy efficiency hold promise for improved cancer diagnostics and personalized medicine.
A team of University of Florida chemical engineers has developed a microfluidic device for DNA purification that extracts genomic DNA without centrifuges or magnetic beads. The device uses fluid flow and electric fields to remove contaminants, resulting in more accurate results and reducing DNA fragmentation.
The study reveals that directional connections propagate signals in a downstream flow, leading to more complex activity patterns. Mathematical models also suggest that modularity and connectivity interact to foster dynamical complexity.
Researchers at Tohoku University developed lab-grown neurons that form complex networks resembling animal nervous systems. These networks exhibit diverse neuronal ensembles and can be reconfigured through repetitive stimulation, mimicking neural plasticity.
Researchers developed a microfluidic chip that can measure memory B cells' binding affinity to flu virus, helping track immunity. The device, Shear Activated Cell Sorting (SACS), can compare how well cells bind to original and new variants.
Researchers at Kyushu University develop a novel technique for building complex 3D microfluidic networks using plant roots and fungal hyphae in silica nanoparticles. This bio-inspired method enables the creation of intricate biological structures, opening new opportunities for research in plant and fungal biology.