Researchers at University of Toronto have developed a new microfluidic platform, ReSCUE, that allows for unprecedented control and manipulation of tumor shapes. This enables the formation, release, and transfer of patient-derived tumoroids, providing insights into how tumor shape predicts cancer cell behavior and aggressiveness.
A new type of cationic epoxy photoresist exhibits greater sensitivity to two-photon laser exposure, enabling fast writing speeds and fine features. The material was developed by a research team led by Professor Cuifang Kuang, who achieved lithography speeds of 100 mm/s and resolution of 170 nm.
Researchers use tongue and groove technique inspired by ancient East Asian wooden structures to create advanced ceramic microparticles with unprecedented complexity and precision. These particles can be used in various applications across microelectronics, aerospace, energy, and medical engineering.
Researchers developed a microchip that captures exosomes from blood plasma to identify signs of lung cancer, achieving 10x faster detection and 14x greater sensitivity. The chip uses twisted gold nanoparticles to distinguish between healthy patients and those with lung cancer.
A new method combines confocal fluorescence microscopy with microfluidic laminar flow to detect nanoparticles and viruses quickly and accurately. The approach uses a 3D-printed Brick-MIC setup for sensitivity and specificity improvements, potentially changing virus detection in clinical settings.
Researchers at Tohoku University developed a new quantitative testing system called the Express Biochecker, which uses Janus particles to detect coronavirus N protein. The system is simple, rapid, and low-cost, with potential applications for other viral illnesses and biomarkers.
Researchers at Kyoto University have developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip that mimics in vivo renal physiology. This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity.
A new approach developed by researchers could streamline the forensic analysis pipeline and reduce delays in processing DNA evidence. The technique, using differential digestion with digital microfluidics, simplifies the process of isolating an assailant's DNA from a single sample, reducing manual steps from 13 to five.
Researchers from HKUST developed a novel magnetic actuation platform enabling the efficient production of sperm-like micro-robots, which demonstrate excellent motility and precision in targeted drug delivery. The Vortex Turbulence-Assisted Microfluidics (VTAM) platform streamlines the production process, paving the way for promising bi...
A new SERS microfluidic system was developed by Shanghai Jiao Tong University researchers, achieving a detection limit lower than 10 ppt of harmful substances. The system uses femtosecond laser-induced nanoparticle implantation into flexible substrate for sensitive and reusable microfluidics detection.
Researchers developed a faster and more precise method to separate particles in fluids, enabling quicker sorting of cells in blood samples and removal of pollutants in water. The improved technique uses specially engineered channels and high polymer concentrations to guide particles and increase accuracy.
Researchers introduced a novel method for improving anti-cancer drug detection using advanced three-dimensional cell culture technology. The new platform enables more accurate assessment of chemotherapeutic agents by simulating physiological conditions that cancer cells encounter in the body.
Scientists studied Crassula muscosa and found its unique leaves pack tiny fins that manipulate the meniscus to direct liquid transport. An artificial mimic, CMIAs, mimics this effect, enabling real-time directional control of fluid flow in various technologies.
A new technology combines femtosecond laser-designed lubricated slippery surfaces with electrostatic interactions to manipulate droplets. This allows for diverse working conditions and functions, including driving droplets on inclined surfaces, manipulating various liquids, and sorting particles.
Researchers at NC State University have developed a technique to create miniature soft hydraulic actuators that can move small soft robots, allowing for exceptional control and delicacy. The actuators use shape memory polymers and microfluidic channels to control the motion and shape change of the soft robots.
Researchers at Texas A&M University developed vessel-chip technology to create a platform for preclinical drug discovery, reducing the need for animal testing. The system mimics human circulatory systems using tissue-engineered microfluidic devices.
A team from Osaka University demonstrates greater control of ion passage through a nanopore membrane by applying a voltage to a gate electrode. This leads to a six-fold increase in osmotic energy efficiency and a power density of 15 W/m^2, enabling the potential for scaling up the technology.
A team of researchers created a microfluidic human cervix model that replicates the complex interactions between cervical epithelial cells, mucus production, and microbiome. The Cervix Chip technology offers a new testbed for bacterial vaginosis therapeutics and other treatments, addressing a key women's health gap.
Researchers at Toyohashi University of Technology developed a novel integrated immunoassay device with autonomous control functions, reducing analysis time by one-third to 30 minutes. The centrifugal microfluidic chip can perform complex fluid control without extensive user training or manual labor.
Elastic turbulence, a chaotic fluid motion in non-Newtonian fluids, exhibits universal power-law decay of energy and intermittent behavior. This study reveals its unexpected similarity to classical Newtonian turbulence, paving the way for developing a complete mathematical theory and predicting flow patterns.
A novel acoustofluidic micropump has been developed to efficiently drive liquid in energy and space, providing robust technical support for portable systems. The micropump exhibits high volume efficiencies and superior energy efficiency, exceeding reported values.
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
A team of researchers from Kyoto University has developed a microfluidic co-culture vasculature chip that mimics the microenvironment of alveolar soft part sarcoma (ASPS), a rare cancer. The chip enables scientists to study cell-to-cell interactions and angiogenic mechanisms, which may lead to new strategies for treating ASPS patients.
Researchers developed a unique microfluidics-based diagnostic system that combines optical tweezers with stimulated Raman spectroscopy to enable fast and accurate diagnosis of leukemia. The device can identify cancer cells based on their metabolic activities and metabolites, providing tailored treatment options.
Researchers from Tokyo Metropolitan University have engineered a micro total analysis system that quantifies target chemicals in a microfluidic chip without pumps or expensive detectors. The device uses gas production to drive ink flow and measure the original chemical concentration.
A microfluidic chip can remove undifferentiated cells that could form tumors before they are implanted in a patient, improving the safety and effectiveness of cell therapy. The device can sort over 3 million cells per minute without causing damage to fully-formed progenitor cells.
Researchers have developed a new microfluidic system that utilizes porous inverse colloidal crystal structures to dramatically improve the efficiency of microdroplet generation. The system can produce droplets around 1,000 times faster than traditional devices, enabling applications in medicine, food, cosmetics, and more.
Researchers from Duke University and Virginia Tech pioneered the integration of aerosol jet printing technology into SAW microfluidic devices. The method reduces fabrication time from 40 hours to 5 minutes per device, offering a faster, more adaptable alternative to traditional methods.
Researchers from Tohoku University and OIST have introduced a miniaturized rotational thermal drawing process, enabling the rapid prototyping of three-dimensional microfluidic systems. This innovation facilitates precise biofluid manipulation and unlocks endless possibilities for combining diverse materials.
Researchers at RIKEN successfully spin artificial spider silk that closely matches natural production, mimicking the complex molecular structure of silk. The eco-friendly innovation has potential benefits for environment and biomedical fields.
Researchers have developed a novel microfluidic magnetic detection system that enables rapid and highly sensitive detection of tumor-derived exosomes, potential biomarkers for cancer diagnosis. The system's serpentine design enhances TDE capture efficiency, while DNA probes augment specificity.
McGill researchers have developed capillaric chips that can be 3D-printed in 30 minutes, enabling on-the-spot testing and potentially making diagnostic tests more accessible. The technology has the potential to speed up diagnoses, enhance patient care, and usher in a new era of accessible testing.
Scientists have found that by controlling ion flow through nanopores, they can achieve cooling. At high concentrations, increased heat was measured, but at low concentrations, negatively charged ions interacted with the nanopore wall, resulting in a decrease in temperature.
Researchers from Tokyo Institute of Technology developed a detailed understanding of microfluidic post-array devices, which are used to create monodisperse emulsions with controlled droplet size. The team found that effective capillary number and specific geometric parameters play crucial roles in droplet formation.
Researchers have developed a new method, SECRE, to identify genetic regulators of cytokine secretion in autoimmune diseases. The technique has been validated on cells known to play a crucial role in inflammatory bowel disease (IBD) and shows promising results for treating conditions with few therapeutic options.
A novel electrical impedance-based microfluidic platform provides rapid and accurate antimicrobial susceptibility testing within an hour, eliminating the need for long-term bacterial culture. The platform reduces human error and increases reliability, making it a promising tool in combating antimicrobial resistance.
Researchers at Xi'an Jiaotong-Liverpool University have developed a sensitive and robust pH sensor that can detect pH variation in just a few microliters of samples. The new sensor uses novel materials and methods to overcome the current method's limitations, which are not sensitive enough or fragile for commercial-scale use.
Researchers developed an integrated microfluidic chip for rapid antimicrobial susceptibility testing from positive blood cultures, reducing diagnosis time to under 3.5 hours. The chip demonstrated high accuracy in diagnosing clinical cases with a 93.3% agreement rate.
Researchers discovered a unique optical signature in magnetic beads, which can be used to detect pathogens like Salmonella. This technique enables quick detection within less than an hour, potentially revolutionizing food and water testing.
Researchers developed a microfluidic platform harnessing acoustic radiation force to manipulate droplets in air, achieving jump heights of up to 128mm. The platform allows for control over the direction and movement of droplets, enabling potential applications in scientific experiments and three-dimensional displays.
Researchers propose lab-on-a-chip platforms to continuously monitor stored RBC quality and match units to patient needs. This technology aims to improve transfusion safety and efficacy, particularly for critically ill patients and those on chronic transfusion regimens.
A novel microfluidic sweat lactate sensor has been developed to measure sweat lactate levels continuously during exercise without interruptions from air bubbles. The device uses a larger-than-usual sweat reservoir to trap air bubbles, preventing them from contacting the sensors' electrodes.
Researchers at Duke University have developed a new approach to building point-of-care diagnostic devices that uses gravity to transport and mix liquid droplets. The device relies on commercially available surface coatings that can tweak the wettability and slipperiness of the channels, allowing for complex fluid paths to be designed.
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
Scientists developed a microfluidic system to study luminal flow around villi in the small intestine, revealing diverse flow behaviors and underlying mechanisms. The device uses air-driven balloon actuators to deform intestinal tissue, generating dynamic flows that can be observed with microscopic fluorescent beads.
The iPODs system enables rapid-results testing with reduced error, cross-contamination, and sample loss by automating droplet transfer. The device shows strong linearity in bacterial detection, with an R-squared value of 0.999, making it accurate for point-of-care testing.
Cascaded microfluidic circuits successfully isolate and purify EVs directly from blood samples within 30 minutes, surpassing ultracentrifugation and dead-end filtration methods. The technology has high clinical potential for early cancer diagnosis and real-time monitoring of tumor development.
A team of researchers has developed a method that uses electric stimulation to accelerate wound healing, making it possible for wounds to heal up to three times faster. The technique involves applying an electric field to damaged skin, which helps guide skin cells in the same direction, promoting faster healing.
Researchers at Shinshu University developed a microfluidic device using acoustic focusing to collect microplastics from water. The device achieved a 105-fold enrichment of MPs, making it an efficient solution for removing microplastics from laundry and industrial wastewater.
Scientists have developed a new microfluidic sperm selection device to improve IVF success rates. The device replicates the natural sperm selection process, resulting in an 85% improvement in DNA integrity and a 90% reduction in sperm cell death.
A WPI researcher is leading a three-year project to investigate the effects of stretching and blood flow on cardiovascular cells in tissue-engineered heart valves. The project aims to expand understanding of mechanical forces that propel cells in the body, with potential applications in other fields like cancer and wound healing.
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
Researchers developed a self-driven lab, AlphaFlow, that uses AI to optimize complex chemical reactions and discover new materials. The system significantly reduces the time needed to develop new chemistries from months to hours.
Researchers at City University of Hong Kong identified lysyl hydroxylase 1 (LH1) as a key factor in promoting confined migration of liver and pancreatic cancer cells. The study found that LH1 promotes metastasis by stabilizing Septin2, which enhances the actin network.
Researchers developed a new device that detects and analyzes cancer cells in blood samples, enabling doctors to avoid invasive biopsies and monitor treatment progress. The Static Droplet Microfluidic device uses metabolic signatures to differentiate tumour cells from normal blood cells.
Key laboratory conducted a literature review on microfluidic actuated and controlled systems for lab-on-chip applications in space life science. The research highlights the challenges and advancements in microfluidic chip technology, including micropumps and microvalves.
Researchers developed a microfluidic model of vascular malformation caused by PIK3CA mutation, allowing them to study disease mechanisms and test treatment efficacy. The model successfully replicated the disease's manifestations and responded to alpelisib, a newly approved PIK3CA inhibitor.
The article analyzes digital microfluidics' (DMF) benefits for bacterial protocols, highlighting its versatility and potential applications in synthetic biology and diagnostics. DMF's electrostatic forces manipulate microdroplets on a plate, enabling sample preparation and nucleic acid detection.
Researchers developed a microfluidic device to model the spleen's filtration function in patients with sickle cell disease. The study found that low oxygen levels can cause the spleen's filters to become clogged, while boosting oxygen levels can unclog them, potentially explaining how blood transfusions help patients.
Researchers at IBS CSLM discovered pair quasiparticles in a classical system of microparticles driven by viscous flow. These long-lived excitations exhibit anti-Newtonian forces that stabilize pairs, similar to the behavior of Dirac quasiparticles in graphene.