Articles tagged with Nanomedicine
Researchers propose protein coronas as a dynamic navigation interface to shape how nanomedicines are recognized and delivered across the blood-brain barrier. The corona can be manipulated to bias circulation, targeting ligands, and intracellular trafficking for improved brain delivery.
Researchers have developed a novel treatment technique using sugar-coated nanoparticles to target and destroy glioblastoma cells. The method overcomes two major obstacles in glioblastoma treatment: delivering therapeutic agents through the blood-brain barrier and targeting tumors preferentially.
A modular nanorobot with a magnetic propulsion module and payload capsule has been developed by researchers at the University of Basel. The system can be adapted to different applications and has shown promise in delivering therapeutic agents to cancer cells, reducing viability by 16% within 72 hours.
Researchers developed DNA tetrahedrons with Vitamin E-derived molecules for targeted cancer treatment, enhancing cellular uptake and improving anticancer efficacy. The modification triggered oxidative stress in cancer cells, leading to programmed cell death.
A comprehensive review reveals how phospholipid asymmetry governs EV surface charge, providing a unified framework for classification, functional understanding, and standardization in nanomedicine. The study highlights the importance of membrane lipid composition and surface charge in determining EV function.
Breast cancer diagnosis and treatment have been enhanced by nanotechnology, improving outcomes for patients. Various formulations such as lipid nanoparticles, nanoemulsions, polymeric nanoparticles, and metal-based nanoparticles offer improved bioavailability and overcome limitations of conventional therapies.
Researchers at University of Michigan Engineering and Michigan Medicine used protein nanoparticles to genetically modify several types of human cells, including liver cancer and immune cells. The goal is to develop a safer method for delivering gene therapies without using modified viruses.
Oregon State University researchers have developed a new class of lipid nanoparticles that can safely deliver gene-editing tools at lower doses, resolving a longstanding challenge in the field. The breakthrough was made possible by a DNA-based barcoding test that measures how efficiently different nanoparticle designs release their cargo.
Emerging biochar-based nanomaterials show promise in tackling global challenges such as climate change and healthcare innovation. These materials may support cleaner energy systems, improved health technologies, and resilient infrastructure through their unique properties and applications.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
A new HPV cancer vaccine developed by Northwestern University scientists has shown promising results in a preclinical model. The vaccine's carefully organized structure dramatically enhances the immune system's ability to attack tumors, shrinking them and extending animal survival.
Researchers at Oregon State University developed a new nanoparticle that enables the removal of melanoma tumors with a low-power laser. The system uses resonance energy transfer to heat up and destroy cancer cells without harming healthy tissue.
The University of Texas MD Anderson Cancer Center has made significant advancements in cancer care through its collaborative efforts between clinicians and scientists. These breakthroughs include an immune-targeting vaccine that shows promise in intercepting cancer in patients with Lynch Syndrome, a novel immunotherapy that demonstrate...
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
Researchers developed Zr-IR825 nanoparticles by combining IR825 with biocompatible metal zirconium, improving water solubility and stability. The material exhibited outstanding photothermal conversion capabilities under near-infrared light, effectively killing tumor cells while showing low toxicity to normal cells.
A Northwestern University study found an injectable regenerative nanomaterial helps protect the brain during a vulnerable window after most common type of stroke. The therapy successfully crossed the blood-brain barrier and reduced brain damage, showing no signs of side effects.
Researchers have developed a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis by suppressing macrophage foam cell formation and inflammation. The study found that mPEG@ELA-11 reduces atherosclerotic plaque area and necrotic core size compared to free ELA-11.
Researchers from Okayama University and Tohoku University have identified a promising way to breach the physical and biochemical barrier created by fibrosis in pancreatic cancer. By blocking collagen signaling through DDR1, they improve drug delivery and enhance treatment response.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers developed a noninvasive approach using nasal drops to deliver potent tumor-fighting medicine to the brain, boosting the immune response and eradicating glioblastoma tumors in mice. The nano-sized medicine successfully activated the STING pathway and armed the immune system to fight the cancer.
Researchers at The University of Osaka have developed an eco-friendly method to produce highly stable and biocompatible gold nanoparticles using microalgae. This breakthrough enables the creation of safer and more effective cancer therapies with fewer side effects for patients.
Anticancer nanoparticles pose risks from drug payloads, nanomaterial accumulation, and bio-corona formation. Measures to improve safety include biodegradable materials, surface engineering, and organ-specific delivery systems.
Scientists re-engineered a common chemotherapy drug to make it more soluble and effective, targeting cancer cells while leaving healthy tissues unharmed. The new nanomedicine significantly extended survival in animal models of leukemia, showing promise for improved cancer treatment.
Researchers have developed lipid-based nanoplatforms (LBNCs) to overcome liver disease treatment barriers, including low drug accumulation and side effects. LBNCs exhibit biocompatibility, versatile drug-loading capacity, and tunable targeting, improving therapeutic effects on fatty liver and HCC.
Researchers propose a novel, data-driven solution using machine learning to predict optimal nanocarrier design for individual patients' tumors. The approach enhances synchronization between drug release and peak tumor proliferation rates, increasing its by a factor of 2.8 compared to traditional static nanocarriers.
Researchers developed DNA-based signaling cascades to report and quantify molecule concentrations in blood, enabling point-of-care devices for optimizing treatment. The breakthrough aids efforts to build affordable and portable devices for monitoring medication levels at home.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
A UVA researcher has created a new way to deliver sustained medical treatments using a polymer-based system that assembles itself inside the body. The technology uses hierarchical assembly to create precise, stable structures that hold and release multiple vaccine components over time.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
Researchers at Carnegie Mellon University's Ren lab have developed AggreBots, microscale living robots made from human lung cells that can be controlled to deliver therapeutic or mechanical interventions. The biobots use cilia, nanoscopic hair-like propellers, for movement and can be programmed to perform specific tasks.
Researchers have created a new class of lipid nanoparticles (LNPs) with complex internal arrangements, expanding their potential for carrying small-molecule drugs, proteins, metal ions, and mRNA. The breakthrough offers flexibility in designing delivery systems for different therapeutic molecules.
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
Researchers at Northwestern University have developed a new CRISPR delivery system that triples efficiency using DNA-wrapped nanoparticles, improving safety and effectiveness. The new system, called LNP-SNAs, targets specific cells and tissues, reducing toxicity and boosting gene-editing efficiency by threefold.
Researchers are using nanodiamonds and VEGF to design treatments for Congenital Diaphragmatic Hernia (CDH), a devastating disease affecting 1 in 3,000 newborns. The treatment aims to stimulate lung growth before birth and improve survival rates.
The seminar, part of a DAAD-JSPS collaboration, will cover the latest topics on drug design and treatment protocols for photodynamic therapy. Researchers from Japan and Germany will present their recent research results on PDT, including nano-DDS applications.
Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers developed pH-responsive graphene-based nanocarriers that can target cancer cells, achieving efficient and safe drug delivery. The material's surface charge adapted to the acidic tumor environment, allowing it to bind and enter cancer cells while avoiding healthy tissues.
Researchers at Nagoya University have developed a new lipid nanoparticle that delivers mRNA five times more efficiently, allowing better delivery of genetic instructions to cells. The study showed significant improvements in mRNA delivery and effective suppression of tumor growth in mice.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
Researchers develop self-assembling nanoparticles that induce ferroptosis in bladder cancer cells while reprogramming the tumor immune microenvironment, boosting anti-tumor activity. The nanomedicine has dual functions as a multifaceted approach to overcome treatment resistance and is Clinically translatable.
Researchers developed breathable and protective HPPT materials with micro/nano-network structures, balancing protection and comfort in medical clothing. The new materials demonstrate exceptional performance, positioning them as promising candidates for next-generation healthcare and wearable protection.
Researchers developed nanomachines that can efficiently deliver antisense oligonucleotides to sentinel lymph nodes, reducing TGF-β1 levels and reactivating depleted CD8-positive T cells. This enhances cancer treatment outcomes for advanced breast cancers with no effective treatments.
Researchers developed self-propelled ferroptosis nanoinducers to enhance cancer therapy by inducing programmed cell death. The nanotherapeutics exhibited enhanced diffusion and deep tumor penetration while maintaining biocompatibility.
Researchers developed a technique to separate and quantify ions, nanoparticles, and aggregates in nanomedicines, improving quality control for advanced pharmaceutical products. This method ensures the safe use of metal-based nanomedicines by distinguishing between their different forms.
Scientists have developed a sugar-coated nanotherapy that effectively traps misfolded proteins, neutralizing their toxic effects on neurons. The treatment significantly boosts the survival of lab-grown human neurons under stress from disease-causing proteins.
Researchers develop nanoparticle-based therapy combining hydroxyl-enriched fullerenol and mTOR inhibitors to disrupt cancer cells' organelle communication system. The approach triggers a synergistic "nanomaterial + metabolic modulation" anticancer strategy, establishing a new hope for treating aggressive cancers.
Researchers at Northwestern University propose a new approach to therapeutic development using structural precision in nanomedicine. By fine-tuning the interaction between nanomedicines and the human body, scientists can design interventions that are more effective, targeted, and beneficial for patients.
A new nanomedicine, ZnDHT NM, selectively targets cancer stem-like cells (CSCs) and tumor cells, promoting CSC differentiation while inhibiting EMT. This approach also leads to the release of toxic compounds in tumor cells, inducing apoptosis/ferroptosis pathways.
The Terasaki Institute for Biomedical Innovation has announced the recipients of its inaugural Keith Terasaki Mid-Career Innovation Award. Dr. Liangfang Zhang and Dr. Aydogan Ozcan were recognized for their innovative approaches to translating groundbreaking research into real-world impact.
Researchers have discovered a green-produced nanosilver-chlorhexidine complex with enhanced antimicrobial and anti-tumor properties. The complex exhibits 18-fold stronger anti-melanoma activity compared to non-functionalized silver nanoparticles.
Researchers developed a novel approach using lipid nanoparticles to deliver mRNA and siRNA, restoring tumor suppressors and inhibiting tumor drivers in prostate cancer cells. This technique holds promise for treating various types of cancer by targeting specific pathways related to tumor growth and suppression.
A new blood test developed by RMIT University researchers could help personalize cancer treatments, making them safer and more effective. The test assesses how well different nanomedicines target cancer cells in the blood of leukemia patients, allowing for more tailored therapies.
Researchers at Chiba University have created an electronically controllable sliding molecular machine using a newly modified ferrocene molecule. The discovery overcomes the challenge of stabilizing the fragile ferrocene molecule on a flat surface, enabling precise control of its motion through electrical signals.
Scientists have captured 3D snapshots of individual RNA nanoparticles in motion, showcasing the dynamic and intricate folding process. This breakthrough uses advanced electron microscopy to study RNA's flexibility, enabling new insights into its structure and potential applications in molecular medicine.
A €9.3 million project will develop AI-powered nanoparticles with complex shapes to specifically bind to biological targets, reducing trial and error in design. The technology has potential applications in disease treatment and advanced communication systems.
Researchers developed a nanomedicine that attacks bacteria at the molecular level, reducing antibiotic resistance and side effects. The technology releases medication only when required, ensuring patients take exact amounts to fight infections.
Researchers developed a novel approach to optimizing siRNA-loaded lipid nanoparticles using NMR-based molecular-level characterization. Pre-mixed LNPs exhibit superior gene-silencing effects due to a stacked bilayer structure that enhances gene silencing.