Articles tagged with Nanomedicine
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Researchers found that endothelial cells in breast cancer tumors are two times more likely to interact with medicine-carrying nanoparticles than healthy endothelial cells. This discovery could lead to more efficient and targeted delivery of cancer nanomedicines.
Researchers used HPICM to study the effect of H2O2 eustress on individual colorectal cancer Caco-2 cells, finding that low levels of H2O2 can increase cell stiffness and negatively impact antioxidant defense. The findings suggest a potential new target for colon cancer treatment, inhibiting GPX under H2O2 eustress.
Researchers developed a simple and efficient method for diversifying reactive end-groups on poly(2-oxazoline)s, enabling rapid exploration of poly(2-oxazoline)-based nanomedicine platforms. The approach was shown to produce POx-based lipid nanoparticles comparable in transfection capability to their PEGylated counterparts.
Researchers at Tokyo Medical and Dental University have developed a novel method for coating engineered messenger RNA molecules with polyethylene glycol (PEG), allowing selective delivery to the spleen. This breakthrough enables fine-tuned control over mRNA therapy, facilitating effective treatment of diseases previously considered inc...
A new nanofluidic implant has been shown to deliver an HIV drug with increased potency compared to existing oral medications, providing a potential breakthrough in addressing treatment nonadherence. The device is intended for long-term controlled release and avoids repeated systemic treatment, which can lead to adverse side effects.
Researchers at the University of Virginia Health System are developing a technique to 'paint' tiny nanoparticles on transplanted veins to prevent blockages, potentially sparing patients from repeated surgeries. This approach could significantly reduce the number of vascular reconstructions performed annually in the US.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
A new approach to fighting HIV has been developed using RNA, specifically small interfering RNAs (siRNA), which regulate gene expression in cells. This nanomedicine was shown to reduce HIV replication by 73% and is intended for vaginal application to prevent sexual transmission.
Researchers develop nanovector nanogels that selectively target glial cells involved in spinal cord injury inflammation, reducing damage and improving recovery. The treatment demonstrates potential for modulating glial cells in neurodegenerative diseases like Alzheimer's.
A team of researchers has developed a novel mixing device that produces nanomedicines directly at the point of care, enabling rapid and cost-effective synthesis of personalized vaccines. The technology has potential implications for cancer therapies and infectious diseases.
A team of researchers from Harvard and Texas developed a soft implantable device with dozens of sensors to record single-neuron activity stably for months. The device uses fluorinated elastomers and is 10,000 times softer than conventional flexible probes.
A team of researchers has devised a method to deliver mRNA into the brain using lipid nanoparticles, offering new hope for treating conditions like Alzheimer's disease and seizures. The approach uses a special keycard-like system to bypass the blood-brain barrier, allowing therapeutic agents to enter the brain and target specific cells.
Researchers successfully reduced bladder tumor size by 90% in mice using nanorobots propelled by urea. The nanomachines deliver a radioisotope to the tumour, attacking it with precision and efficiency. This breakthrough could lead to more effective bladder cancer treatments and reduced hospitalization costs.
Scientists in Germany developed a new analytical method to precisely elucidate the size of particles, structure, and RNA molecules in pharmaceutical products. This information can help evaluate product quality, enabling improved development of new products.
Researchers developed an immunodriven strategy to increase nanoparticle penetration through tumor vascular basement membranes, enhancing therapeutic effect. By breaking through the BM barrier, NPs can deliver drugs more effectively, increasing treatment efficacy.
Engineers developed a nanoparticle vaccine targeting S100A9, a protein that attracts cancer cells to the lungs. The vaccine significantly reduced lung tumor growth and improved survival rates in mice with metastatic breast cancer after surgery.
Jinglei Ping, a UMass Amherst engineering professor, has received a $1.9 million grant to investigate a new method of regulating exosome traffic using electronic signals. This approach aims to control cell communication in cancer and heart disease research.
Researchers developed a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors. The study showed that regulators being studied effectively inhibited complement activation by nanoparticles in human serum in vitro and animal models.
Researchers discovered age-related differences in how the liver filters the bloodstream, affecting nanomedicine distribution and effectiveness. Younger livers are more efficient at filtering out toxins but also filter out beneficial treatments.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers discovered that titanium micro-spikes with rough surfaces can effectively kill drug-resistant fungus and Candida species through apoptosis. The findings suggest that these surface features may be a promising approach to combatting superbug resistance.
Researchers at the University of Sydney have developed a nanoscale optical technique to monitor protein aggregates forming in cells, which can lead to neurodegenerative diseases such as Alzheimer's and ALS. The study provides a new window into the transition of proteins from liquid to solid phase.
Researchers at NUS have developed a new treatment method that reduces the size and increases the stability of atherosclerotic plaques in arterial walls. The treatment involves injecting omega-3 fatty acids into the bloodstream via nanomedicine, which helps to reduce inflammation and prevent plaque rupture.
Researchers at the University of Missouri have developed a new type of nanoclay material that can be customized to perform specific tasks. This breakthrough could lead to advances in fields such as medical science, environmental science, and more.
Researchers have developed a biodegradable fluorescent nanoprobe to detect diabetic retinopathy (DR) at its early molecular stage. The nanoprobe binds to VEGFR-2, expressed in the retinal microvessels, allowing for early diagnosis and intervention.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
Researchers have developed a new method to manipulate the shape of double-stranded DNA, known as triplex origami, which can create compacted structures with unique properties. This breakthrough has implications for gene therapy, nanoscale materials engineering, and our understanding of biological processes.
Researchers developed tiny nano-sized pores that can detect specific proteins in complex biological fluids, such as blood. The breakthrough enables fast and accurate disease diagnosis, potentially leading to earlier interventions and improved treatment outcomes.
A team of researchers from the University of Oklahoma and Yale University has developed a super-resolution imaging platform technology to visualize nanoparticles within cells. The technique, called expansion microscopy, enables 3-D imaging with resolutions as low as 10 nanometers, allowing for safer and more efficient nanomedicines.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Scientists have identified a novel mechanism of gel formation in synthetic polymers, which leads to the creation of worm-like structures. This breakthrough has significant implications for biofabrication and could lead to the development of new medical implants, contact lenses, and other applications.
Researchers have developed an implantable nanofluidic device that delivers CD40 monoclonal antibodies to shrink pancreatic tumors, reducing treatment dosage by fourfold. The device's long-term controlled release avoids systemic side effects, offering a promising alternative for cancer patients.
Researchers have developed nanodiscs based on the cell membranes of human red blood cells, which can effectively neutralize bacterial toxins. These nanodiscs, called RBC-NDs, are biocompatible and non-toxic, making them potentially useful as nanovaccines.
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
A new nanomedicine platform targets brain lipid metabolism to reduce food intake and body weight in mice, offering a promising approach for managing metabolic diseases like obesity. The study demonstrates the effectiveness of this novel treatment, which could potentially provide an innovative solution for controlling energy balance.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
Researchers developed a novel pH-activated nanocytokine system using IL-12, which enhances immunity and eradicates tumors in murine models. The nanocytokine controls inflammation through spatiotemporal regulation, blocking counteractive immune responses and reducing toxicity.
A recent study by MSU researcher Morteza Mahmoudi found that less than 2% of proteins identified in nanomedicine analyses were the same across different labs. This extreme lack of consistency poses a significant challenge to ensuring the accuracy of diagnostics and treatments based on nanomedicines.
A wafer-thin device called NICHE has been developed to treat Type 1 diabetes by delivering islet cells and immunotherapy directly into the body. The device restored healthy glucose levels and eliminated symptoms for over 150 days, avoiding severe adverse effects of anti-rejection therapy.
Nucleic acid therapies aim to treat genetic disorders and diseases, but delivering therapeutics is a significant challenge. Researchers are investigating nanoparticle delivery systems to target specific cells and sub-cellular compartments for effective delivery.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers developed bioresponsive polymers for targeted delivery and controlled release of therapeutic agents. However, achieving exclusive selectivity remains a challenge due to complex biology.
Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.
SUTD researchers leverage nanosecond electroporation to deliver cancer-related molecules into living cells with excellent viability. The platform enables pores to remain open for up to 720 minutes, paving the way for efficient drug delivery and other applications.
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
Researchers developed size-tunable PEG-grafted copolymers to target muscle tissues by exploiting the blood-muscle barrier. The optimal size range for extravasation was found to be between 11-32 nm, with accumulation in skeletal muscles of Duchenne muscular dystrophy model mice being significantly higher than in normal mice.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
Researchers developed nanoparticles with a changeable net charge that facilitates intratumor accumulation and penetration, achieving 32.1% of injected dose/g of tissue. This study suggests using the changeable net charge as a promising strategy for tumor-targeted delivery based on the EPR effect.
A multidisciplinary team at CSIC introduces silicon chips into living cells, allowing study of cell division processes and potential for interfering with the cell cycle. This research opens new lines of investigation in nanomedicine.
Researchers at Aarhus University have developed improved DNA nanostructures that can assemble biomolecules with multiple functions, increasing the effectiveness of cancer treatment. The new structures are more stable, non-toxic, and immune system-friendly than previous versions.
Recent progress in targeted nanomedicine for managing resistance and toxicity of cisplatin in cancer therapy is reviewed. The article highlights strategies to increase cisplatin sensitivity through improved intracellular concentration and combination therapy, as well as novel approaches targeting tumor microenvironment and immunotherapy.
Recent nanomedicines are being explored for brain cancer treatment due to their ability to improve bioavailability and evade the blood-brain barrier. These supramolecular nanomedicines show potential in promoting superior therapeutic effects by targeting brain tumors specifically.
Scientists have created a new technology using colour pigments from the food industry to stimulate nerve cells with the help of implantable mini solar cells. This innovation could lead to accelerated healing and prevention of complications in severe brain injuries, as well as potential applications in pain therapy and retinal implants.
Researchers at MUSC have developed a device to remove toxic chemotherapy drugs, such as doxorubicin, from the blood after cancer treatment. The device uses heat and an activated carbon filter to effectively remove the drug, potentially reducing harmful side effects.
Researchers have developed a novel nanocarrier system that synergizes poly(l-ornithine) for mRNA protection with charge-conversion polymer for endosomal escape. This innovation enhances protein expression efficiency by approximately 80-fold, outperforming traditional PLL-based systems.
Researchers at Tel Aviv University developed a drug delivery system based on lipid nanoparticles that utilize RNA to boost personalized cancer care. The nanodrug enhances chemotherapy effectiveness and reinvigorates the immune system, increasing sensitivity to cancer cells.
The team used a microscale diffuser to distribute ultrasound waves uniformly, reducing the risk of over-exposure or under-exposure. The device successfully stimulated cells in human embryonic kidney cells and neuron cells, as well as mice, with improved targeting.
A new fabric developed by MIT engineers can detect subtle heartbeat features and the direction of sudden sounds, enabling real-time monitoring of vital signs. The fabric works like a microphone, converting sound vibrations into electrical signals.
Researchers at Massachusetts General Hospital found that using nanomedicines at lower, more frequent doses can normalize the tumor microenvironment and improve cancer treatments. The study showed that this approach can help correct abnormalities that protect tumors and improve blood vessel function and immune activation within a tumor.