Articles tagged with Nanomedicine
Liangfang Zhang's invention uses human cell membranes to cloak nanoparticles, making them deliver drugs and remove toxins more effectively. The approach has shown promise against bacterial toxins, including MRSA, and may potentially treat diseases without conventional drugs.
A team of researchers has demonstrated a novel nanomedicine approach to diagnose and treat ectopic pregnancy, showing promise in improving outcomes for women with this life-threatening condition. The new treatment uses magnetic nanoparticles to detect and disrupt ectopic pregnancies, reducing the risk of complications and mortality.
Researchers at IIT have created nanoparticles that can heat up using infrared light, release antioxidant substances, and stimulate cells when activated by ultrasound. These multifunctional nanotubes have the potential to modulate cellular activity and be used in regenerative medicine and neurostimulation.
Researchers at Memorial Sloan Kettering Cancer Center have developed nanoparticles that can selectively eliminate a small population of immune cells found to drive fibrosis, potentially paving the way for new approaches against immunotherapy-resistant tumors and fibrotic diseases. The approach could make immunotherapy work for more pat...
Researchers developed a nanomedicine that combines photothermal therapy, STING activation, and immune checkpoint blockade to convert
Scientists developed laser-carved microvalves to protect fragile brain catheters from backflow, enabling smooth delivery of therapies. The valves regulate fluid flow through geometry without moving parts, suppressing reverse pressure surges by up to 82%.
Two nanomedicine projects will be developed to combat cancer, with the first focusing on cholangiocarcinoma and the second on ovarian cancer. The projects will utilize intelligent nanomedicines capable of adapting to individual tumor characteristics and energy supply, with the goal of more precise and effective therapies.
A modular nano-adaptor approach tunes T-cell activation to control CD3 activation and prevent toxicity, increasing therapeutic effectiveness in solid tumors. The platform has identified promising lead designs for multispecific nanoantibody configurations.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
Researchers at IIT Gandhinagar develop a gold nanorod-based platform for ER-targeted cancer treatment, combining targeted drug delivery with photothermal therapy. The approach induces ER stress-mediated autophagy and apoptosis in cancer cells.
Researchers at Kumamoto University have created a mobile drug delivery platform using polyrotaxanes to simplify targeting the liver. The platform achieves cellular uptake efficiency comparable to conventional systems, while reducing manufacturing complexity.
Researchers from Pusan National University developed an injectable system to deliver radiation directly within keloid tissue, providing a minimally invasive approach to treat abnormal scars. The microgels enabled rapid and efficient radiolabeling, and therapeutic efficacy was demonstrated in mice carrying patient-derived keloid tissue.
Researchers developed a method to inhibit lipid nanoparticle migration into the liver by coating hepatic sinusoidal walls with polyethylene glycol. This coating reduced liver accumulation by several dozen times and increased protein expression in the spleen, promoting safer nanomedicine with lower dosages.
Recent research explores the use of nanomaterial-based drug delivery to increase treatment efficacy for glioblastoma, a type of brain tumor with poor prognosis. Stimuli-responsive and biomimetic nanomedicines are designed to overcome the blood–brain barrier and deliver drugs selectively within tumors.
Researchers develop world's first oral microbiome-based nanomedicine to enhance immune cells' ability to attack cancer cells. The new drug, Prodrug 201, significantly increases bioavailability and effectively directs stem-like T cells into tumor sites.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
Emerging non-endocytic delivery strategies enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools, providing new opportunities for biomedical therapies. The review discusses their application prospects in gene therapy, macromolecular drug delivery, and cellular engineering.
A research team has overcome two major hurdles for photo thermal therapy, a less invasive treatment option than surgery and radiation. They created a new biodegradable protein called IDP1 that helps nanoparticles avoid immune detection, and developed an ultra-thin endoscope to deliver laser light directly into tumors.
Researchers developed a nanoparticle system that uses cancer cells' own copper resources to activate cuproptosis, eliminating tumor cells while protecting healthy tissue. The targeted nanoparticles showed enhanced cellular uptake and were more lethal to breast cancer cells than non-targeted versions.
Researchers created nanozyme proximity labeling (NPL) to visualize protein interactions and trafficking pathways of nanoparticles in live cells. The technique provides a high-resolution, in situ snapshot of how surface modifications influence nanoparticle destinations.
A new imaging technology at UH helps scientists study exosomes, tiny particles released by human cells that may be targets for diseases. The technology uses advanced lighting at the nanoscale to analyze exosomes one at a time, measuring features to pinpoint good drug targets.
Researchers propose protein coronas as a dynamic navigation interface to shape how nanomedicines are recognized and delivered across the blood-brain barrier. The corona can be manipulated to bias circulation, targeting ligands, and intracellular trafficking for improved brain delivery.
Researchers have developed a novel treatment technique using sugar-coated nanoparticles to target and destroy glioblastoma cells. The method overcomes two major obstacles in glioblastoma treatment: delivering therapeutic agents through the blood-brain barrier and targeting tumors preferentially.
A modular nanorobot with a magnetic propulsion module and payload capsule has been developed by researchers at the University of Basel. The system can be adapted to different applications and has shown promise in delivering therapeutic agents to cancer cells, reducing viability by 16% within 72 hours.
A team at the University of Basel has developed a modular nanorobot with propulsion and payload modules that can be used in medicine to deliver active substances to specific locations in the body. The technology also has potential applications in industry and environmental technology.
Researchers developed DNA tetrahedrons with Vitamin E-derived molecules for targeted cancer treatment, enhancing cellular uptake and improving anticancer efficacy. The modification triggered oxidative stress in cancer cells, leading to programmed cell death.
The study uses DNA barcodes to track and compare dozens of gold nanoparticle designs in living tumour models, identifying those effective at reaching mitochondria. Two formulations emerged as standout performers, achieving high tumour regression when combined with RNA therapy and photothermal treatment.
A comprehensive review reveals how phospholipid asymmetry governs EV surface charge, providing a unified framework for classification, functional understanding, and standardization in nanomedicine. The study highlights the importance of membrane lipid composition and surface charge in determining EV function.
Breast cancer diagnosis and treatment have been enhanced by nanotechnology, improving outcomes for patients. Various formulations such as lipid nanoparticles, nanoemulsions, polymeric nanoparticles, and metal-based nanoparticles offer improved bioavailability and overcome limitations of conventional therapies.
Researchers at University of Michigan Engineering and Michigan Medicine used protein nanoparticles to genetically modify several types of human cells, including liver cancer and immune cells. The goal is to develop a safer method for delivering gene therapies without using modified viruses.
Oregon State University researchers have developed a new class of lipid nanoparticles that can safely deliver gene-editing tools at lower doses, resolving a longstanding challenge in the field. The breakthrough was made possible by a DNA-based barcoding test that measures how efficiently different nanoparticle designs release their cargo.
Emerging biochar-based nanomaterials show promise in tackling global challenges such as climate change and healthcare innovation. These materials may support cleaner energy systems, improved health technologies, and resilient infrastructure through their unique properties and applications.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
A new HPV cancer vaccine developed by Northwestern University scientists has shown promising results in a preclinical model. The vaccine's carefully organized structure dramatically enhances the immune system's ability to attack tumors, shrinking them and extending animal survival.
Researchers at Oregon State University developed a new nanoparticle that enables the removal of melanoma tumors with a low-power laser. The system uses resonance energy transfer to heat up and destroy cancer cells without harming healthy tissue.
The University of Texas MD Anderson Cancer Center has made significant advancements in cancer care through its collaborative efforts between clinicians and scientists. These breakthroughs include an immune-targeting vaccine that shows promise in intercepting cancer in patients with Lynch Syndrome, a novel immunotherapy that demonstrate...
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
Researchers developed Zr-IR825 nanoparticles by combining IR825 with biocompatible metal zirconium, improving water solubility and stability. The material exhibited outstanding photothermal conversion capabilities under near-infrared light, effectively killing tumor cells while showing low toxicity to normal cells.
A Northwestern University study found an injectable regenerative nanomaterial helps protect the brain during a vulnerable window after most common type of stroke. The therapy successfully crossed the blood-brain barrier and reduced brain damage, showing no signs of side effects.
Researchers have developed a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis by suppressing macrophage foam cell formation and inflammation. The study found that mPEG@ELA-11 reduces atherosclerotic plaque area and necrotic core size compared to free ELA-11.
Researchers from Okayama University and Tohoku University have identified a promising way to breach the physical and biochemical barrier created by fibrosis in pancreatic cancer. By blocking collagen signaling through DDR1, they improve drug delivery and enhance treatment response.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers developed a noninvasive approach using nasal drops to deliver potent tumor-fighting medicine to the brain, boosting the immune response and eradicating glioblastoma tumors in mice. The nano-sized medicine successfully activated the STING pathway and armed the immune system to fight the cancer.
Researchers at The University of Osaka have developed an eco-friendly method to produce highly stable and biocompatible gold nanoparticles using microalgae. This breakthrough enables the creation of safer and more effective cancer therapies with fewer side effects for patients.
Anticancer nanoparticles pose risks from drug payloads, nanomaterial accumulation, and bio-corona formation. Measures to improve safety include biodegradable materials, surface engineering, and organ-specific delivery systems.
Scientists re-engineered a common chemotherapy drug to make it more soluble and effective, targeting cancer cells while leaving healthy tissues unharmed. The new nanomedicine significantly extended survival in animal models of leukemia, showing promise for improved cancer treatment.
Researchers have developed lipid-based nanoplatforms (LBNCs) to overcome liver disease treatment barriers, including low drug accumulation and side effects. LBNCs exhibit biocompatibility, versatile drug-loading capacity, and tunable targeting, improving therapeutic effects on fatty liver and HCC.
Researchers propose a novel, data-driven solution using machine learning to predict optimal nanocarrier design for individual patients' tumors. The approach enhances synchronization between drug release and peak tumor proliferation rates, increasing its by a factor of 2.8 compared to traditional static nanocarriers.
Researchers developed DNA-based signaling cascades to report and quantify molecule concentrations in blood, enabling point-of-care devices for optimizing treatment. The breakthrough aids efforts to build affordable and portable devices for monitoring medication levels at home.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
A UVA researcher has created a new way to deliver sustained medical treatments using a polymer-based system that assembles itself inside the body. The technology uses hierarchical assembly to create precise, stable structures that hold and release multiple vaccine components over time.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
Researchers at Carnegie Mellon University's Ren lab have developed AggreBots, microscale living robots made from human lung cells that can be controlled to deliver therapeutic or mechanical interventions. The biobots use cilia, nanoscopic hair-like propellers, for movement and can be programmed to perform specific tasks.
Researchers have created a new class of lipid nanoparticles (LNPs) with complex internal arrangements, expanding their potential for carrying small-molecule drugs, proteins, metal ions, and mRNA. The breakthrough offers flexibility in designing delivery systems for different therapeutic molecules.
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
Researchers at Northwestern University have developed a new CRISPR delivery system that triples efficiency using DNA-wrapped nanoparticles, improving safety and effectiveness. The new system, called LNP-SNAs, targets specific cells and tissues, reducing toxicity and boosting gene-editing efficiency by threefold.
Researchers are using nanodiamonds and VEGF to design treatments for Congenital Diaphragmatic Hernia (CDH), a devastating disease affecting 1 in 3,000 newborns. The treatment aims to stimulate lung growth before birth and improve survival rates.
The seminar, part of a DAAD-JSPS collaboration, will cover the latest topics on drug design and treatment protocols for photodynamic therapy. Researchers from Japan and Germany will present their recent research results on PDT, including nano-DDS applications.
Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.