A phase II trial found that PD-1 blockade with dostarlimab induced complete tumor clearance and resolved the need for surgery in patients with early-stage mismatch repair-deficient cancers. This approach showed promise for preserving organs, improving quality of life, and potentially increasing survival.
A topical BRAF-inhibiting gel, LUT014, improved acneiform rash in 69% of patients with grade 2 or 3 rash and received an EGFR-targeted antibody. The treatment also showed a 33% success rate for the placebo arm, but was associated with similar adverse events.
Researchers found that pretrained foundation models outperformed a standard baseline model in identifying nonmelanoma skin cancer from digital images. The models achieved accuracies of up to 92.5% in distinguishing between NMSC and normal tissue, significantly improving upon an older architecture.
A new AI-driven biomarker model analyzes imaging and clinical data to predict cancer cachexia with high accuracy, improving detection rates by up to 85% compared to standard methods. The model's skeletal muscle quantification function was trained using annotated CT scans and validated on a separate set of images.
A new CAR NK cell therapy has shown promising results in treating relapsed or refractory blood cancers, particularly AML. The therapy, SENTI-202, employs logic gating to improve specificity and reduce toxicity, and has been associated with complete remissions in seven of nine patients.
A phase III clinical trial found that adding pembrolizumab before and after surgery improved responses and survival in patients with previously untreated, locally advanced head and neck squamous cell carcinoma. Patients treated with pembrolizumab were at least 27% less likely to have experienced recurrence.
A phase I clinical trial found that zoldonrasib elicited objective responses and disease control in patients with KRAS G12D-mutated NSCLC. The study demonstrated the efficacy and tolerability of the oral agent, which selectively targets the active conformation of KRAS.
A new study found that staying active through moderate-to-vigorous physical activity is associated with significantly better processing speed, working memory, and executive function in older adults. Even small changes to daily activities can have big impacts on brain health.
Researchers have developed a highly sensitive method to detect nitazenes – highly potent synthetic opioids – and xylazine, an animal sedative not approved for human use, in Australian wastewater. The method achieved up to 1000-fold enrichment and detected trace levels of these substances, posing significant risks of overdose.
A team led by Prof. Liu Junwei from HKUST observed the first experimental evidence of a two-dimensional layered room-temperature altermagnet, validating theoretical predictions made in 2021. The research demonstrates C-paired spin-valley locking in a layered antiferromagnet compound, revealing new opportunities for developing high-dens...
A clinical trial found that LUT014, a topical BRAF inhibitor, significantly reduced the severity of acne-like skin rashes caused by targeted therapy for colorectal cancer. Patients who received LUT014 had improved quality of life and were able to continue receiving their cancer treatment with reduced side effects.
Researchers developed oscillating microbubble array-based metamaterials for efficient isolation of high-purity exosomes from undiluted whole blood. The technology, tested on whole blood samples, isolated exosomes with 93% purity in about three minutes without labeling or pretreatment procedures.
A Phase II trial found durable antitumor activity in patients with BRCA1/2 mutations treated with olaparib and pembrolizumab, with 8.3% complete response rate
Researchers explored CFRP-RC composites to overcome brittle failure and residual deformation in conventional shear walls. A refined size-effect correction model was proposed to address limitations in seismic performance prediction, paving the way for more resilient designs.
The consensus outlines evidence-based strategies for case selection, biomechanical principles, and clinical procedures to enhance clear aligner therapy. It introduces a novel difficulty-assessment tool and recommends tailored approaches for complex tooth movements, such as molar distalization and arch expansion.
New research shows that controlling key health risks like blood pressure, cholesterol, and lifestyle behaviors can significantly reduce premature mortality among hypertensive individuals. The study found that those who achieved high levels of joint risk factor control had no greater risk of early death than people without hypertension.
Iron-based magnetic nanomaterials have shown potential in drug delivery, magnetic hyperthermia, and iron deficiency treatment. They influence macrophage reprogramming through enzyme-like activities, modulating intracellular iron metabolism and regulating cell signaling pathways.
Researchers develop nanoparticle-based therapy combining hydroxyl-enriched fullerenol and mTOR inhibitors to disrupt cancer cells' organelle communication system. The approach triggers a synergistic "nanomaterial + metabolic modulation" anticancer strategy, establishing a new hope for treating aggressive cancers.
Researchers at H. Lee Moffitt Cancer Center & Research Institute have discovered a way to enhance immunotherapy for NRAS-mutant melanoma. Blocking nitrosylation triggers immunogenic cell death, attracting immune cells to destroy cancer cells and limiting tumor growth.
The AACR Trailblazer Cancer Research Grant Program awards $1 million grants to early-stage and mid-career investigators over three years. The program aims to advance cancer biology, drive translational science, and improve patient outcomes.
A phase 3 clinical trial shows that adding pembrolizumab to standard-of-care therapy increases tumor shrinkage and prolongs cancer-free survival by nearly two years. Patients with locally advanced head and neck cancers benefited from this addition, marking a significant change in standard-of-care for the disease.
The treatment demonstrated early signals of efficacy, with 65.7% of patients experiencing lasting stable disease, and was generally well-tolerated, with most adverse events being mild and manageable.
Researchers identified cartilage oligomeric matrix protein (COMP) as a key driver of abnormal collagen I accumulation in OSF. Targeting COMP's interaction with collagen XIV may halt or reverse the disease's progression, offering hope for more effective treatments.
The American Association for Cancer Research (AACR) announces its 2025 Scientific Achievement Award recipients, honoring outstanding contributions to cancer research. This year's awardees include Rakesh K. Jain, PhD, FAACR, and Han Liang, PhD, recognized for their groundbreaking work on tumor microenvironment and cancer bioinformatics,...
The American Association for Cancer Research (AACR) will honor Senator Tammy Baldwin and Senator Shelley Moore Capito for their national leadership in advancing cancer prevention and treatment. The organization also recognizes Larry Saltzman, MD, a cancer survivor who has surpassed his expected lifespan due to NIH funding.
Researchers discovered temperature influences plant cell fate by regulating epigenetic marks. Low ambient temperatures can rescue developmental defects by compensating for PRC2 loss, highlighting the importance of H3K27me3 in maintaining cellular identity.
Dr. Richard Pazdur, MD, receives the 2025 AACR Enduring Impact Award for his quarter century of service in cancer science and medicine. He has led an era of progress at the FDA, improving outcomes for patients with cancer through expedited development of novel therapeutics.
KIAA1199, a secreted protein from bone marrow cells, influences both fat storage and overall energy metabolism. Researchers found that mice lacking KIAA1199 exhibited reduced fat mass and improved insulin sensitivity, suggesting targeting the protein could lead to new treatments for metabolic disorders.
Researchers uncover pivotal role of ZmCCT2 in regulating maize mesocotyl length and adapting to high altitudes. Significant associations between genetic variations and mesocotyl lengths were found, highlighting the essential function of ZmCCT2 in promoting cell elongation.
Researchers developed atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes, showcasing high turnover frequencies and regioselectivity. The catalyst's efficiency surpasses both homogeneous and heterogeneous counterparts, with applications in tritium labeling.
Researchers developed a novel process for direct production of syngas via super-dry reforming of methane using solid oxide electrolysis cells. The system achieved high CH4 conversion and selectivity toward CO and H2, showcasing potential for CO2 utilization and renewable energy storage.
Researchers developed a 1.7-gram head-mounted microscope to capture neural activity and cerebral hemodynamics in freely moving mice. The device provided simultaneous imaging of neuronal burst firing and multi-parametric hemodynamics at high spatiotemporal resolution.
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
A cohort study of pregnant individuals with opioid use disorder found that buprenorphine treatment was associated with improved maternal and infant outcomes. The study highlights the need to improve access to treatment nationwide for these patients.
A study on donor lungs preserved outside the body demonstrated that HOPE is a safe and effective method for lung preservation, with no rejections and similar short-term outcomes compared to direct transplantation. The study found that extending perfusion times can optimize donor lungs for future therapies.
A phase 3 clinical trial showed that pembrolizumab before and after standard-of-care surgery significantly extends event-free survival and substantially shrinks tumors in head and neck cancer patients. This regimen has improved outcomes without delays in surgery, marking a potential new standard of care for this patient population.
The Pediatric Heart Transplant Alliance is a coalition of six leading organizations working to advance pediatric heart transplantation through research, education, and advocacy. The alliance aims to improve patient outcomes and quality of life for children with transplanted hearts.
Researchers at ISHLT marked the 10-year anniversary of modern DCD heart donation, significantly increasing transplant volumes worldwide. Comparable outcomes have been achieved with DCD hearts compared to traditional DBD hearts, leading to a surge in DCD programs globally.
Machine perfusion technology significantly extends the time donor hearts can be transported, enabling longer-distance transplants. This innovation has already led to more organs being accepted from regions previously unsuitable due to transportation constraints.
Pediatric hearts fail due to acquired and genetic disorders or congenital heart disease, requiring mechanical circulatory support (MCS) devices. However, adult devices are often used off-label in pediatric patients, deterring innovation and limiting access to life-saving technology.
A CFD simulation method based on biological experimental data analyzed the aerodynamic performance of pigeons during different flight stages. The study found that pigeons enhance lift during takeoff by attaching leading-edge vortex earlier and maintain stable lift during leveling flight.