A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Researchers developed a facile hydrogen atom transfer method using xanthone as a promising ketone photocatalyst for activating carboxylic acids. The method generates minimal reaction waste and has broad applicability with over 40 examples. It also reveals a novel photocatalysis of ketones.
A multicenter study in China found that low-dose hydroxychloroquine (≤600 mg/day) is associated with reduced COVID-19 mortality among hospitalized patients, particularly those with severe illness. The study suggests that low-dose HCQ may confer mortality benefits while minimizing safety risks, supporting cautious use in severe cases.
A new online program aims to improve body image and wellbeing for people with Inflammatory Bowel Disease (IBD). The 10-module program uses mindfulness techniques, cognitive behavioural therapy, and self-compassion training to help patients overcome negative thought patterns and social comparisons.
Researchers discovered the spin configuration of excited states in a typical zero-dimensional metal halide material, challenging traditional views on dual-peak emission. The study reveals that the low-energy peak includes both bright and dark states, while the high-energy peak is from a pure bright state.
Researchers develop self-assembling nanoparticles that induce ferroptosis in bladder cancer cells while reprogramming the tumor immune microenvironment, boosting anti-tumor activity. The nanomedicine has dual functions as a multifaceted approach to overcome treatment resistance and is Clinically translatable.
Researchers analyzed PBMCs from individuals with phlegm-dampness constitution and non-Tanshi controls, identifying reduced MAIT cells and increased classical monocytes. Transcriptomic analyses revealed heightened inflammatory pathways, supporting the association between Tanshi constitution and metabolic syndrome.
Researchers introduce a novel method for generating topological optical textures using simple photonic crystal slabs, leveraging BICs to achieve alignment-free and high-fidelity topological light generation. This discovery paves the way for practical applications in communication, sensing, and data processing.
Researchers developed an AI-powered microscope system to measure soil fungi presence and quantity, providing insights into soil health and fertility. The low-cost optical microscopy with machine learning technology can be used by farmers and land managers worldwide.
A new study by Tel Aviv University's Moshe Dayan Center finds that 73.2% of Israel's Arab citizens support the inclusion of an Arab party in the government after elections, leading to a potential increase in voter turnout. This optimism is seen amidst low mood in Arab communities due to recent conflicts and violence.
Researchers developed a novel neuron-like interface material and bioelectronic platform that enables seamless integration and adaptive communication with neural systems. The platform, termed ferroelectric bioelectronics (FerroE), integrates neuron-like flexibility, surface topography, and functional behaviors into a single system.
Researchers from UCLA have developed innovative biomaterial strategies to mimic immunological synapses, enhancing T cell activation rates and long-term efficacy in CAR-T therapy. The approaches leverage flexible interfaces and mechanical properties to promote memory T cell formation and distribution.
Research reveals ADA2's critical role in monocyte differentiation and activation, modulating lysosomal adenosine levels and influencing inflammatory pathways. Elevated ADA2 levels correlate with increased pro-inflammatory cytokines, while low levels foster an immunosuppressive milieu.
Researchers at the University of Sydney developed a biological 'artificial intelligence' system called PROTEUS, which can accelerate cycles of evolution and natural selection to create molecules with new functions in weeks. The system has potential applications in finding new medicines and improving gene editing technology like CRISPR.