The new atomic fountain clock, NIST-F4, has been established as one of the world's most accurate timekeepers by NIST researchers. The clock measures a constant frequency in cesium atoms and has improved time signals used billions of times daily for various applications.
A new study reports on five patients with Canavan disease who have a novel variant identified through targeted long-read sequencing, revealing an SVA_E retrotransposable element that disrupts gene function. The findings enhance genetic diagnostics and enable improved guidance for families.
Research by NIOO-KNAW reveals that less intense farming practices, such as reduced ploughing and increased grass-clover mixtures, can improve soil health and multifunctionality in both conventional and organic agriculture. This approach, known as 'productive de-intensification,' aims to retain crop yields while enhancing soil functions.
The Arctic Great Rivers Observatory, a multinational project founded at the Marine Biological Laboratory, has been recognized as a National Champion by the Frontiers Planet Prize for its publication on recent trends in the chemistry of major northern rivers. This recognition highlights the value of sustained international collaboration...
A recent study suggests that computer science teachers have greater education and classroom experience compared to teachers of other subjects. The study found that students' learning in computer science was positively impacted by teachers' experience teaching the subject.
Three UTA faculty members, Kyrah Brown, Ben Jones, and J. Ping Liu, received top honors for their groundbreaking research contributions. Brown's interdisciplinary work focuses on reproductive and cardiac health among women, while Jones' research explores neutrinos to understand the universe's mysteries.
A Yale-related nonprofit, Mati Carbon, has won the four-year, $100 million XPRIZE Carbon Removal competition with its method of crushed rocks to remove heat-trapping CO2 from the atmosphere. The process, called Enhanced Rock Weathering (ERW), also improves soil health for farmers.
Researchers with City of Hope will present innovative clinical trial results, breakthrough diagnostic techniques, and advances in treatment options at the AACR Annual Meeting. Highlights include a phase 3 clinical trial showing promising results for novel immunotherapy against nasopharyngeal carcinoma.
A new study from Thomas Jefferson University investigates the use of ondansetron to ease withdrawal symptoms in newborns with neonatal opioid withdrawal syndrome (NOWS). Researchers found that a specific concentration of ondansetron can significantly reduce withdrawal symptoms.
Researchers at Thomas Jefferson University used computational biology to analyze blood samples from people with and without ALS, discovering different combinations of small non-coding RNAs associated with disease progression and survival times.
A new voluntary program, the Medicare Prescription Payment Plan (MPPP), could greatly reduce out-of-pocket costs for Medicare patients taking expensive oral cancer drugs. By spreading annual costs across 12 monthly payments, patients can avoid large upfront payments and make treatment more affordable.
The University of Tennessee and Volkswagen Group of America have partnered on strategic research projects accelerating technology discovery and commercialization. The two have collaborated on lighter composites, high-power wireless charging and material upcycling, influencing Volkswagen brands globally.
Researchers found that using rice malt instead of milled rice in beer brewing can decrease production costs by 2-12%. Malted rice also requires less crop-growing acreage, making it a viable alternative for craft brewers. The study suggests that malting could open up new markets for Arkansas rice and ensure its long-run sustainability.
The Westermarck Archives, stored at Åbo Akademi University Library, have been inscribed on the UNESCO Memory of the World Register. The collection contains correspondence, manuscripts, notes, and photographs from Westermarck's field studies in Morocco, providing insights into anthropology, sociology, and local cultures.
A misfolded protein in spinal fluid facilitates reliable Parkinson's diagnosis even in its early stages. The biomarker has a sensitivity and specificity of over 90%, making it a promising tool for disease management and potential therapy development.
Scientists have developed a cutting-edge technology to analyze protein turnover in individual cells, enabling them to identify treatment-resistant cancer cells and understand the impact of specific drugs. This breakthrough could lead to advancements in disease diagnostics and treatment strategies.
Researchers at Northwestern University propose a new approach to therapeutic development using structural precision in nanomedicine. By fine-tuning the interaction between nanomedicines and the human body, scientists can design interventions that are more effective, targeted, and beneficial for patients.
A recent study published in Journal of Experimental Medicine found that immune cells play a major role in the development of spastic paraplegia type 15. The research, led by Professor Elvira Mass and Dr. Marc Beyer, suggests that severe inflammation in the brain precedes neuronal damage and could be relevant to Alzheimer's disease.
The new Priority Program will focus on developing IT components utilizing altermagnetism, which combines the benefits of ferromagnets and antiferromagnets. Researchers aim to overcome current limitations and achieve a significant increase in efficiency and speed.
Researchers at City of Hope discovered a novel target for preventing age-related abdominal fat by identifying the cellular culprit behind midsection widening in middle age. The study found that aging triggers the arrival of new adult stem cells and enhances the body's massive production of new fat cells, especially around the belly.
Methyl eugenol has demonstrated notable antioxidant and antiproliferative activity, with potential therapeutic benefits for diseases like Alzheimer's disease and cancer. However, its toxicological risks, including hepatotoxicity and alterations in the gut microbiota, pose concerns for its application.
Researchers developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack, showing effectiveness up to five weeks after injection.
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
A recent study published in PLOS Biology found that behavioral experiments with insects exhibit a high level of non-reproducibility, with some results varying as much as 42%. Despite this, at least half of the findings could be successfully reproduced.
This study examines the effectiveness of combining microvascular decompression with nerve combing for patients with atypical trigeminal neuralgia, a chronic pain condition that does not respond well to conventional treatments. The procedure has shown promising results in reducing pain levels and improving patient outcomes.
Researchers have discovered important differences in how a targeted therapy behaves in the body over time, allowing for more tailored treatment strategies. A new PET/CT scanner also shows promise for accurate imaging with dramatically reduced exposure, especially for sensitive patients like children or those needing repeated scans.
A new study compares tropical mountain ice cores to climate model simulations, revealing discrepancies in Earth's average temperature trends. Researchers found that ice core data and computer models match for polar regions like Greenland and Antarctica, but not for tropical mountains.
A new NYU Langone Health study found that lung immune cell type nerve and airway-associated interstitial macrophages (NAMs) play a critical role in regulating inflammation during SARS-CoV-2 infection. NAMs promote disease tolerance by restraining the immune response, leading to better survival rates among infected mice.
Researchers at Tohoku University developed a surface reconstruction pathway to produce durable non-noble metal-based cathodes for efficient hydrogen evolution reaction (HER) performance, paving the way for affordable commercial production.
The study estimates that expanded Medicare coverage for GLP-1RAs would increase access to these treatments and reduce obesity-related comorbidities. However, this would come with substantial costs over a decade, projected at $8 billion, highlighting the need for further price reductions and cost-saving strategies.
Researchers at MD Anderson Cancer Center present promising results from clinical trials in three minisymposia abstracts. The studies explore personalized vaccine combination therapy for colorectal cancer, radiotherapy to avoid toxicities of systemic treatments for kidney cancer, and engineered exosomes to silence mutant KRAS in pancrea...
A team of researchers at POSTECH has identified a hidden mechanism in Electrochemical Random-Access Memory (ECRAM) technology, enabling faster and more efficient AI computations. This breakthrough could lead to significant improvements in data processing and reduced energy consumption.
The study reveals significant lattice-driven CDW fluctuations in KV₃Sb₅ at temperatures far exceeding its CDW transition, providing new insights into underlying mechanisms. The research team observed in-plane band folding and lattice distortions at temperatures up to 150 K.
A new study finds that radioiodine therapy significantly increases relative survival rates in differentiated thyroid cancer patients, with benefits observed across low-, intermediate-, and high-risk subgroups. The treatment reduces recurrence rates and improves long-term survival in high-risk groups, while also showing promise for low-...
Researchers found that super-Earths can exist far from their host star like gas giants do from the sun. The team's results suggest these massive worlds are prevalent across the universe, with at least one super-Earth present for every three stars.
Researchers developed Draw2Cut, a novel vision system that allows users to draw directly onto materials to be cut or milled. The system creates 3D CAD plans for CNC machines, reducing complexity in manufacturing.
Researchers are developing atomically dispersed catalysts to make industrial processes cleaner and more efficient. However, the field is plagued by common pitfalls, including inadequate testing and characterization. Experts like Jason Bates and E. Charles Sykes emphasize the need for repeatable, rigorous science.
A study led by IGTP identifies an epigenetic signature of 156 altered CpG sites in primary tumours that can help stratify patients according to their risk of developing distant metastases. The findings contribute to a better understanding of the disease and open new avenues for patient stratification and personalised treatment strategies.
Cigarette smoking prevalence is expected to decrease in the US by 2035, primarily among young adults in historically high-prevalence states. This trend is likely to slow health consequences, particularly for older adults.
Researchers from the University of Cincinnati Cancer Center presented abstracts highlighting contrasting effects of a protein on head and neck, breast, and lung cancers. The study found increased levels of IL-9 in patients with head and neck cancer correlated with decreased survival, while elevated IL-9 was associated with smaller tumo...
Researchers from Dana-Farber Cancer Institute are presenting findings across various cancers, including head and neck cancer, metastatic breast cancer, and lung cancer. A combination therapy showed promise in phase 1 results for patients with metastatic breast cancer.
A University of Ottawa-led study reveals that serotonin neurons are connected and interact with each other, controlling serotonin release in specific regions of the brain. This complex system has implications for understanding decision-making and developing targeted therapeutics for mood disorders.
The Taishan Antineutrino Observatory's unique plastic scintillator module design boasts exceptional performance in muon identification efficiency, surpassing 99.67% even at high thresholds. This scalable solution establishes a transferable technique for next-generation neutrino detectors requiring muon identification efficiency >99.5% ...
Yafang Cheng's research on atmospheric aerosols has brought fundamental insights and impactful public outreach, addressing grand challenges of global change. The Copernicus Gesellschaft e.V. recognizes her innovative work, promoting international collaboration in the geosciences.
The CoVaRR-Net network successfully bridged critical research and public health gaps exposed by the COVID-19 pandemic through interdisciplinary collaboration and innovative approaches like wastewater surveillance. Its achievements include 139 peer-reviewed publications, evidence-based public health decisions, and a global leader in ear...
Researchers created a comprehensive human T cell reference for 68 subtypes and states, alongside the STCAT tool, achieving 28% higher accuracy than existing methods. The tool allows users to browse T cell expression profiles and analyze customized scRNA-seq data.
A long-term shift towards drier conditions is reshaping landscapes and livelihoods globally, affecting 40% of Earth's land and 2.3 billion people. The research highlights solutions to adapt to a future where water is no longer guaranteed, including smarter irrigation strategies, data analytics, and restoring degraded land.
A new microfluidic chip design enabled precise control over interstitial flow and shear stress distribution, leading to sustained microvascular growth for over 12 days. The study found that rectangle chambers exhibited the highest network density due to uniform low shear stress, mimicking physiological capillary conditions.
Bonn researchers found higher numbers of type 3 innate lymphoid cells in duodenum tissue of FAP patients, producing interleukin-17A which stimulates ROS production and DNA damage. This suggests a local environment favoring cancer development, prompting a new approach to preventing duodenal cancer.
The VAST project seeks to understand the normal human virome, the vast ecosystem of viruses living in and on humans. By analyzing tens of thousands of samples from diverse populations, researchers aim to identify how a healthy virome shifts with disease or environmental factors.
Research finds that 40Hz sensory stimulation promotes broad-based restorative neurological health response in mice with Down syndrome. The study shows improved cognition, increased neural activity, and enhanced neurogenesis, suggesting potential therapeutic benefits.
A phase 1 trial involving 40 patients showed significant responses to the new cell therapy IMA203, with half of non-responders achieving lasting response. The therapy targets PRAME peptide produced by many tumors and was well-tolerated.
A research team developed a novel strategy to balance high catalytic activity and durability under industrial-level conditions. They constructed a MOF@POM superstructure that undergoes an in-situ transformation into a single-layer CoFe hydroxide catalyst, exhibiting exceptional performance in alkaline electrolytes.
The Coalition of Autism Scientists rejects false narratives about autism incidence and causes, urging HHS to focus on established research approaches. The group demands respect for autism research and calls for the Secretary's plan to be registered, with public comment and data sharing.
Researchers demonstrated CycloneSEQ's ability to sequence complete bacterial genomes with long-read data and hybrid assembly methods. This work has improved our understanding of microbial functions by closing gaps in genomic assemblies, particularly for complex bacterial communities.
A recent study used AI to discover that phosphoglycerate dehydrogenase (PHGDH) is a causal gene for spontaneous Alzheimer's disease. The researchers found that altering PHGDH expression levels can significantly impact the progression of the disease, suggesting a novel therapeutic target.
Dr. Robert C. Bast, Jr., a pioneer in cancer science, receives the AACR-Daniel D. Von Hoff Award for his decades-long dedication to nurturing the next generation of cancer research leaders. His groundbreaking discoveries have saved countless lives and transformed ovarian cancer detection and management.
The journal aims to advance cutting-edge research and engineering applications in flexible materials, devices, and systems. It covers topics such as biomedical materials, soft robotics, human-machine interaction, and energy storage.
Researchers found that 90% of participants had at least one sign of dry eye disease, with significant progression after one year. The study highlights the need for early detection and advice on managing the condition through simple methods such as taking screen breaks and maintaining a healthy lifestyle.
Researchers identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions. The study found that one subtype, C10, becomes more prevalent with age and is harder to kill with existing drugs.
A global survey of 156 institutions found that technical limitations, such as haptic precision issues, and financial constraints are significant barriers to the adoption of VR-haptic technology in dental education. The study suggests that cost-reduction innovations and targeted faculty training are needed to address these challenges.
Researchers developed collagen-based scaffolds that can integrate with a vascular and perfusion organ-on-a-chip reactor to form complete tissue engineering platforms. The team demonstrated the ability to create non-planar 3D networks in soft, organic material by printing helical vascular networks modeled after DNA structure.
The conference aims to facilitate interdisciplinary collaboration and promote academic-industry partnerships. Original research submissions are welcome across various fields of interest including electronics, communication systems, and intelligent science applications.
A recent study found that cigarette smoking continues to decline across the US, mainly driven by young adults. The states with historically high smoking rates have seen the most significant declines in smoking prevalence.
Scientists developed an injectable therapy that protects the heart from damage after a heart attack by blocking the interaction between two proteins, Keap1 and Nrf2. The study showed decreased inflammation, cell death, and improved cardiac function in animal models.
A new study found that climate change may undermine the capacity of Arctic fjords to serve as effective carbon sinks, leading to a decline in sequestration carbon. Rapid changes are transforming fjord ecosystems, with phytoplankton communities shifting due to melting ice and warmer waters.
The Hong Kong Bauhinia Genome Project has completed a decade-long effort to sequence the DNA of Hong Kong's floral emblem, revealing 28 complete chromosomes and solving the species' parentage. The project's T2T genome assembly provides insights into genetic mechanisms underlying its vibrant blooms and ecological adaptability.
Researchers found that both bonobos and chimpanzees console peers at similar rates, but with greater variation within each species. Older apes are less likely to comfort younger ones in both groups.
Researchers at EPFL discovered that iron-rich hematite exhibits new spin physics, enabling signal processing at ultrahigh frequencies and allowing repeated encoding and storage of digital data. This breakthrough paves the way for a more efficient and sustainable approach to spintronics.
Scientists at the University of Copenhagen have created 'super stem cells' that outperform regular stem cells by developing into multiple cell types. These 'super stem cells' show promise in improving fertility treatment, particularly IVF success rates, by producing essential tissue for early embryonic development.
A recent study found significant elevated expression of AID enzyme in B cells during Plasmodium falciparum malaria, linking the parasite to the development of Burkitt lymphoma. Elevated AID levels were also observed in Kenyan children with uncomplicated malaria.
Researchers used Minecraft to investigate how humans dynamically integrate asocial and social information in realistic contexts. The study found that adaptability is the most important driver of success, and that flexible switching between individual and social learning strategies amplifies human intelligence.
A new study finds that pregnant women treated with buprenorphine have significantly better health outcomes, including reduced preterm birth rates and lower risk of NICU admission. The research highlights the urgent need for expanded treatment access to vulnerable populations.
Researchers at Ohio State University have identified new targeted therapies for treating small cell lung cancer, predicting melanoma spread, and reducing endometrial cancer risk. A 31-gene expression profile has been developed to identify patients at high risk of melanoma spread, allowing for closer monitoring and earlier treatment.
A 20-year initiative that offered flexible screening options at a major health system doubled screening rates and cut cancer incidence by a third, halving deaths. The program eliminated racial disparities in outcomes, with Black patients' deaths declining from 52.2 to 23.5 per 100,000.
A new study found that artificial intelligence can better estimate the prevalence of physical abuse in children seen in emergency departments. The AI model correctly identified child abuse in over 35% of cases, outperforming traditional methods that relied solely on diagnostic codes entered by providers or administrative staff.
A recent study found that telehealth visits in pediatric primary care significantly reduced antibiotic prescriptions for acute respiratory tract infections. The research analyzed over 540,000 visits and showed that children treated with telehealth were less likely to receive antibiotics than those examined in person.
Researchers found that some shark bites are motivated by self-defense when sharks feel threatened or provoked. This discovery challenges the common perception of sharks as mindless predators and highlights the importance of respecting their space.
A recent study found that children with chronic conditions are hospitalized for respiratory syncytial virus (RSV) at twice the rate as healthy children. Researchers recommend that these children receive immunization against RSV in their first season to increase protection, regardless of maternal vaccination status.
Researchers used umbilical cord blood to analyze genetic changes linked to metabolic dysfunction in children. The study found multiple regions of altered DNA associated with metabolic issues later in childhood.
A multinational study found that erythropoietin treatment does not prevent death or disability in newborns with critically low levels of oxygen or blood supply to the brain. The research compared outcomes between babies treated with controlled cooling and those receiving both erythropoietin and cooling, but showed no benefit from the a...
Researchers identified five blood proteins that can predict liver disease up to 16 years before symptoms. The combined levels of these proteins achieved high accuracy in predicting disease onset and progression, suggesting potential for early diagnosis and treatment.
A nationwide study reveals that education about firearm safety significantly increases parents' likelihood of asking others about guns in homes their children visit. The research found that caregivers who received information from multiple sources were more likely to ask about firearms, emphasizing the need for ongoing and multifaceted...
Researchers identified four specific genes linked to lethal stomach cancers, enabling potential targeted treatments and less aggressive procedures for some patients. The study's findings support a more personalized approach to treatment based on each patient's tumor biology.
Researchers found that antibiotic exposure in the first two years of life was significantly associated with a higher body mass index (BMI) in childhood. The study followed 33,095 vaginally born children in Finland to see if antibiotics before pregnancy, during pregnancy, and after birth were linked to higher BMI at age two and age 12.
Researchers developed a new DNA-reading technology that identified more genomic imprinting in DNA, contributing to rare pediatric diseases. The study used HiFi long-read sequencing to analyze over 200 genetic samples and found widespread parent-of-origin effects on methylation at thousands of novel loci.