Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Scientists have identified a novel mechanism of gel formation in synthetic polymers, which leads to the creation of worm-like structures. This breakthrough has significant implications for biofabrication and could lead to the development of new medical implants, contact lenses, and other applications.
Researchers have developed an implantable nanofluidic device that delivers CD40 monoclonal antibodies to shrink pancreatic tumors, reducing treatment dosage by fourfold. The device's long-term controlled release avoids systemic side effects, offering a promising alternative for cancer patients.
Researchers have developed nanodiscs based on the cell membranes of human red blood cells, which can effectively neutralize bacterial toxins. These nanodiscs, called RBC-NDs, are biocompatible and non-toxic, making them potentially useful as nanovaccines.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateMar 29, 2023
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
A new nanomedicine platform targets brain lipid metabolism to reduce food intake and body weight in mice, offering a promising approach for managing metabolic diseases like obesity. The study demonstrates the effectiveness of this novel treatment, which could potentially provide an innovative solution for controlling energy balance.
Researchers developed a novel pH-activated nanocytokine system using IL-12, which enhances immunity and eradicates tumors in murine models. The nanocytokine controls inflammation through spatiotemporal regulation, blocking counteractive immune responses and reducing toxicity.
A recent study by MSU researcher Morteza Mahmoudi found that less than 2% of proteins identified in nanomedicine analyses were the same across different labs. This extreme lack of consistency poses a significant challenge to ensuring the accuracy of diagnostics and treatments based on nanomedicines.
A wafer-thin device called NICHE has been developed to treat Type 1 diabetes by delivering islet cells and immunotherapy directly into the body. The device restored healthy glucose levels and eliminated symptoms for over 150 days, avoiding severe adverse effects of anti-rejection therapy.
Nucleic acid therapies aim to treat genetic disorders and diseases, but delivering therapeutics is a significant challenge. Researchers are investigating nanoparticle delivery systems to target specific cells and sub-cellular compartments for effective delivery.
SourceWiley·JournalWiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology·DateNov 23, 2022
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers developed bioresponsive polymers for targeted delivery and controlled release of therapeutic agents. However, achieving exclusive selectivity remains a challenge due to complex biology.
Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.
SUTD researchers leverage nanosecond electroporation to deliver cancer-related molecules into living cells with excellent viability. The platform enables pores to remain open for up to 720 minutes, paving the way for efficient drug delivery and other applications.
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
Researchers developed size-tunable PEG-grafted copolymers to target muscle tissues by exploiting the blood-muscle barrier. The optimal size range for extravasation was found to be between 11-32 nm, with accumulation in skeletal muscles of Duchenne muscular dystrophy model mice being significantly higher than in normal mice.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
Researchers developed nanoparticles with a changeable net charge that facilitates intratumor accumulation and penetration, achieving 32.1% of injected dose/g of tissue. This study suggests using the changeable net charge as a promising strategy for tumor-targeted delivery based on the EPR effect.
A multidisciplinary team at CSIC introduces silicon chips into living cells, allowing study of cell division processes and potential for interfering with the cell cycle. This research opens new lines of investigation in nanomedicine.
Researchers at Aarhus University have developed improved DNA nanostructures that can assemble biomolecules with multiple functions, increasing the effectiveness of cancer treatment. The new structures are more stable, non-toxic, and immune system-friendly than previous versions.
Recent progress in targeted nanomedicine for managing resistance and toxicity of cisplatin in cancer therapy is reviewed. The article highlights strategies to increase cisplatin sensitivity through improved intracellular concentration and combination therapy, as well as novel approaches targeting tumor microenvironment and immunotherapy.
Recent nanomedicines are being explored for brain cancer treatment due to their ability to improve bioavailability and evade the blood-brain barrier. These supramolecular nanomedicines show potential in promoting superior therapeutic effects by targeting brain tumors specifically.
Scientists have created a new technology using colour pigments from the food industry to stimulate nerve cells with the help of implantable mini solar cells. This innovation could lead to accelerated healing and prevention of complications in severe brain injuries, as well as potential applications in pain therapy and retinal implants.
Researchers at MUSC have developed a device to remove toxic chemotherapy drugs, such as doxorubicin, from the blood after cancer treatment. The device uses heat and an activated carbon filter to effectively remove the drug, potentially reducing harmful side effects.
Researchers have developed a novel nanocarrier system that synergizes poly(l-ornithine) for mRNA protection with charge-conversion polymer for endosomal escape. This innovation enhances protein expression efficiency by approximately 80-fold, outperforming traditional PLL-based systems.
Researchers at Tel Aviv University developed a drug delivery system based on lipid nanoparticles that utilize RNA to boost personalized cancer care. The nanodrug enhances chemotherapy effectiveness and reinvigorates the immune system, increasing sensitivity to cancer cells.
The team used a microscale diffuser to distribute ultrasound waves uniformly, reducing the risk of over-exposure or under-exposure. The device successfully stimulated cells in human embryonic kidney cells and neuron cells, as well as mice, with improved targeting.
A new fabric developed by MIT engineers can detect subtle heartbeat features and the direction of sudden sounds, enabling real-time monitoring of vital signs. The fabric works like a microphone, converting sound vibrations into electrical signals.
Researchers at Massachusetts General Hospital found that using nanomedicines at lower, more frequent doses can normalize the tumor microenvironment and improve cancer treatments. The study showed that this approach can help correct abnormalities that protect tumors and improve blood vessel function and immune activation within a tumor.
Researchers examine ways to target specific neurons using nanomedicine, aiming to improve treatment options for neurodegenerative diseases like Alzheimer's and Parkinson's. The study highlights the challenges of delivering drugs to specific populations of neurons in the brain.
Researchers at the University of South Australia have developed a new way to deliver chemotherapy drugs, using liposomal formulations that target tumors more effectively. This breakthrough could improve treatment outcomes for thousands of cancer patients, reducing side effects and improving quality of life.
Researchers have identified the impact of protein corona formation on nanoparticles' physiochemical and biological properties. This knowledge can be used to optimize carriers for nanomedical applications, improving the efficiency and effectiveness of biopharmaceutical delivery.
Researchers at Penn Medicine have discovered a new method to prevent the body's proteins from attacking treatment-carrying nanoparticles, allowing for more effective delivery of therapies. By coating nanoparticles with natural suppressors of complement activation, such as Factor I, the team has shown improved protection against immune ...
A new targeted nanomedicine treatment developed at the University of Chicago has shown promise in reducing vascular lesions caused by atherosclerosis. The treatment delivers medicine directly to inflamed cells, targeting the site of inflammation and inhibiting stenosis, the remodeling of vascular tissue that causes it to close off.
Researchers have developed a ferritin-based nanomedicine that targets diverse leukemia types, improving therapeutic efficacy and reducing toxicity. The nanomedicine delivers arsenic to leukemia cells, enhancing killing effects while minimizing harm to normal tissues.
Researchers created polymersomes that target highly invasive cancer cells, delivering anticancer drugs and preventing metastasis. The nanomachines showed strong antitumor effects in breast cancer models, inhibiting lung metastasis and prolonging survival.
A new antibody delivery technology enhances anti-PD-L1 antibody accumulation in glioblastoma by 33-fold, achieving a 60% complete response rate with long-term immune memory. The technology also suppresses immune-related adverse events.
Researchers developed an AI tool that can quickly and accurately identify suspicious proteins in the body by analyzing their movements. The method, known as diffusional fingerprinting, uses machine learning algorithms to predict protein behavior with over 90% accuracy.
Researchers have discovered that dendrimer tentacles can avoid detection by the complement system, part of our immune system. This could lead to developing a new system for delivering drugs into the body without triggering an immune response.
A new microneedle patch containing cerium nanoparticles has been designed to combat both primary causes of baldness: oxidative stress and insufficient circulation. The patch showed faster hair regrowth in a mouse model compared to a leading treatment.
Researchers have developed poly-ion complex (PIC) nanomicelles loaded with CPT1A inhibitors to deliver drugs into brain cells, reducing fatty acid oxidation and improving treatment for glioblastoma. The delivery system successfully increased cellular concentration of the cargo and biological activity.
Researchers explore integrating reactive oxygen species generation and prodrug activation to enhance cancer therapy. Stimuli-responsive nanomedicines can target tumors, generating ROS that activate drug release, offering promising synergetic therapy strategies.
Researchers explore connections between preclinical and clinical modeling to develop unique animal-based disease models. Integration of active-targeting ligands and smart materials enhances nanomedicine functionalities, paving the way for new-concept nanoparticle-based drugs.
Research by MSU's Morteza Mahmoudi suggests that Covid-19 vaccines developed with nanomedicine may have different efficacies for men and women due to sex-based differences. The study highlights the importance of considering sex in vaccine development and research, particularly in using nanomedicines.
Researchers developed polymeric nano-micelles that target specific levels of c-Myc expression, a key factor in cancer cell proliferation. The study showed varying efficacy depending on tumor c-Myc expression levels, with higher expression associated with better antitumor activity.
Researchers have developed a unique combination of microscopy techniques to study the biological effects of nanoparticles and their interaction with human plasma. This approach allows for an unprecedented view of the nanoparticle's 'corona', also known as its biological 'crown', which contains clues about how nanoparticles interact wit...
Researchers have developed ultra-small nanomedicines that stably deliver oligonucleotides to refractory cancers, such as brain tumors and pancreatic cancer. These nanomedicines use Y-shaped block copolymers and nucleic acid drugs, achieving high permeability in cancer tissues and stability in the bloodstream.
The authors review future directions of nanomedicine development focusing on the mechanism of nanoparticle entry into tumors. Designing better nanoparticles to achieve efficient clinical transformation can be informed by a deep understanding of the mechanism of nanoparticle entry or the mode of action.
The Kawasaki Institute of Industrial Promotion has opened a new website for Project COINS, which aims to establish an in-body hospital network by 2045. The initiative is part of the Center of Innovation Program (COI) and will focus on creating innovative healthcare and medical technologies.
Researchers at Eindhoven University of Technology prove the Velcro method enhances selectivity in drug particle binding based on receptor number and strength. This allows precise targeting of diseased cells while distinguishing them from healthy ones.
The BIO Integration Virtual Conference Series July 2020 examines the intersection of nanomedicine, biology, and technology. Key topics include the integration of naturally occurring bioactive compounds into nanomedicine and nanoparticles meditated LncRNA silencing for effective cancer radiotherapy.
Scientists propose advanced engineering strategies for gas-releasing nanomedicines to enhance bioavailability and safety of therapeutic gases. These nanomedicines aim to maximize profits in gas therapy by providing controlled release and targeting cancer cells.
A nanomedicine expert proposes a cancer care model for managing COVID-19, focusing on early detection, regular monitoring, and targeted treatment. This approach could improve patient outcomes by providing systematic management of the pandemic.
Researchers at Stockholm University discovered engineered silica particles can reduce food efficiency, leading to lower weight gain and improved metabolic profiles in mice. The study suggests these particles could be used to treat obesity and diabetes in humans.
Researchers developed an exosome-based nanomedicine that increases tumor accumulation and penetration after intravenous administration. The biocompatible nanomedicines combine natural biomaterials with synthetic nanoparticles, demonstrating potential for improved anticancer drug efficacy.
Researchers have developed a nanotherapeutic called S-HDL that reduces inflammation in blood vessels, halting plaque accumulation and vessel wall inflammation in animal models. The new production method boosts therapeutic yields by up to 80-fold, paving the way for human application.
Lauren Sciences LLC has received an AU$1 million grant from FightMND to advance its development of LAUR-301, a novel V-Smart Nanomedicine for ALS. The therapy aims to protect motor neurons and induce neuro-restoration, slowing or reversing the disease.
Researchers from NUS discovered that certain nanoparticles can widen the gap between blood vessel cells, making it easier for cancer cells to spread. This phenomenon, named NanoEL, accelerates tumor growth and causes circulating cancer cells to escape from blood circulation.
Recent review highlights latest advances in precise nanomedicine for intelligent cancer therapy, exploring metallofullerenol nanoparticles, supramolecular chemo-therapy, and DNA nanorobots. These strategies aim to improve cancer imaging and therapeutic applications while understanding nanotoxicity.