Researchers from City of Hope identified how a protein receptor targeted by 33% of all federally approved medications works. This discovery could facilitate pharmaceutical research and lead to the creation of innovative medicines with fewer side effects.
The NSF is funding projects that utilize the International Space Station (ISS) National Laboratory to advance tissue engineering and mechanobiology research. This solicitation aims to further drug discovery and therapeutic development through space-based research, with potential impacts on regenerative medicine and disease diagnosis.
Scientists from the University of Arizona have discovered a giant active mantle plume pushing the surface of Mars upward, causing earthquakes and volcanic eruptions. The finding suggests that Mars' deceptively quiet surface may hide a more tumultuous interior than previously thought.
A team of researchers proposes an intelligent routing scheme to optimize link load balancing in software-defined networks, achieving significant performance improvements. Their algorithms outperform traditional methods, reducing maximum bandwidth by 24.6 percent in real-world topologies.
A meta-analysis of over 884 studies found that certain micronutrients can benefit cardiovascular health, including omega-3 fatty acids, folic acid, and CoQ10. These supplements have been shown to reduce the risk of cardiovascular disease, stroke, and mortality.
A study by Marta Antonelli and colleagues highlights the pressing challenges in the Mediterranean region, including worsening water scarcity, biodiversity loss, and nutritional imbalances. The gap between North and South countries is expected to grow, with climate change exacerbating environmental pressures and threatening food security.
The use of smartwatches to screen for faulty heart rhythms needs more evaluation, according to a cardiologist. Smartwatch detection of AF can often point to cases of the disorder, but substantial work is needed to integrate this consumer-received information into optimized care. Recent studies have reported low rates of irregular heart...
Research highlights bullying as a significant concern for adolescent LGBTQ+ individuals, particularly females. Findings show rising trends in bullying and suicidal behavior across demographic subgroups of US adolescents.
A large study found that most Canadian children and adults younger than 60 had been exposed to SARS-CoV-2 through a combination of vaccination and infection. The study, conducted in British Columbia, shows a dramatic change in the proportion of the population with antibodies over the first 2.5 years of the pandemic.
A study using spatial single-cell transcriptomics reveals the spatial organization of cancer cells in patient tissues across ages and locations. The research highlights age- and location-dependent differences in tumor biology, suggesting that kids and adults with diffuse midline gliomas may need different treatments.
Researchers have developed a CAR-T therapy approach that effectively targets and eliminates rogue immune cells responsible for autoimmune diseases like multiple sclerosis. The treatment shows promise as a potential cure for debilitating conditions.
A recent study reveals that the SD6/ICE2 molecular module regulates seed dormancy in rice, controlling abscisic acid homeostasis. By editing this gene, researchers improved pre-harvest sprouting resistance in both rice and wheat, offering a promising strategy for improving crop yields.
A new analysis of Michigan bees reveals that both high-quality habitats and diverse species communities can positively impact bee health by reducing common viral pathogens. However, the researchers also found that improving habitat quality features like floral density may not necessarily benefit pollinator health.
A study by Alex Van Zant and colleagues found that sellers who lied during financial negotiations felt less satisfied with the outcome and more guilty than those who were honest. The researchers also discovered that having a greater incentive to lie did not reduce feelings of guilt, but rather increased them.
A new study has deciphered the mechanical code of DNA, revealing previously unknown ways in which nature encodes biological information. Researchers used a next-generation technology to show that local sequence determines local bendability of DNA.
The study found conserved structures of neuronal activity in the sensorimotor cortex of freely moving rats, revealing a clear gradient for contralateral bias. This breakthrough helps understand brain control of movements under natural conditions and enables further development of neuroprosthetic devices.
Researchers identify an off-patent liver disease drug that can prevent SARS-CoV-2 entry into cells, potentially offering protection against future variants. The study used a unique combination of 'mini-organs', animal studies, and human subjects to demonstrate the drug's effectiveness.
Researchers at ORNL developed a cleaner, more efficient method for making high-capacity cathode material without cobalt. The new hydrothermal synthesis approach reduces environmental impact and increases production speed.
Research by University of East Anglia reveals care home nurses were unprepared for the pandemic, impacting their mental health and wellbeing. The study suggests implementing a mental health and wellbeing strategy is crucial to promote recovery from trauma and moral distress.
Researchers successfully reconstructed a two-billion-year-old enzyme, shedding light on an ancient evolutionary mechanism that enables modern enzymes to work efficiently despite interruptions. The study reveals the ancestral enzyme is processive, removing correctly added nucleotide building blocks, and shows how bioinformatics and bioc...
Researchers at the University of Missouri are developing a wearable heart monitor using a breathable material with antibacterial and antiviral properties. The device will track heart health via dual signals, providing continuous monitoring for early detection of heart disease.
Researchers used high-resolution radar systems to reconstruct past ice streams in Greenland, revealing they can 'shut down' rapidly. This insight offers new information on the future behavior of ice streams and how it affects sea-level rise predictions.
The use of real-world laboratories can facilitate knowledge exchange between science and society, enabling the development of participatory research approaches to address the complex challenges facing our oceans. By involving all relevant stakeholders in co-designing research questions and testing potential strategies, these labs have ...
Researchers at the University of Illinois Chicago synthesized semiconductor quantum dots with extended radiative lifetimes and spatially localized electrons, enabling new applications in optics and time-gated single-particle imaging. The study's findings hold promise for energy-efficient displays and biomedical research.
A new study published in JAMA Neurology found that using hearing aids can decrease the risk of cognitive decline by 20%. The study, conducted by researchers at NUS Medicine, analyzed data from over 130,000 participants and found a significant association between hearing aid use and reduced cognitive decline. The findings suggest that t...
A new study found that 39 out of 43 California's coastal airports have assets exposed to projected flooding by 2100. Sixteen airports have assets within their boundaries, while 23 have assets outside their jurisdiction at risk from flooding. The study highlights the need for collaborative climate adaptation plans to address this issue.
A study of parrot vocal learning reveals species-specific differences in mimicking human speech, with some birds using words in context. Researchers also found that age and sex are weak predictors of vocal mimicry, highlighting the importance of conservation efforts for these complex communicators.
A new study found that consumer skepticism about whole-grain food labels contributes to low intake globally. Consumers prefer clear, straightforward labeling on product names rather than generic claims.
A new study suggests that a transcriptomic technique can help distinguish between infections and non-infectious causes of complications following knee and hip replacement surgery. The technique uses RNA sequencing to determine which genes are expressed and identifies specific immune cell types involved in the response to infection.
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers found a strong association between consuming more ultraprocessed foods and cognitive decline in adults. The study, which included over 10,700 participants, suggests that limiting such food intake may support current public health recommendations to protect cognitive function.
Researchers have created a method to edit the genomes of bacteriophages, viruses that infect bacteria, using CRISPR technology. This innovation has the potential to revolutionize the control of microbiomes and treat dangerous drug-resistant infections.
A systematic review of 23 studies found COVID-19 mRNA vaccine-associated myopericarditis is rare in adolescents and young adults with a low incidence rate. The condition generally has favorable early outcomes, but continued follow-up is recommended.
NUS researchers have developed a low-cost, non-invasive cancer testing method that sequences clinical samples heated to isolate cancer-specific signatures in patient blood. The Heatrich-BS assay has high sensitivity comparable to gold standard CT scans and costs around US$35 from start to finish.
Researchers synthesized multisource data to explore spatiotemporal variations of melt/freeze onsets, revealing a 3-month delay in basal freeze onset compared to surface. The study highlights the importance of synchronous monitoring of air-ice-ocean system and suggests a possible delay in Arctic sea ice loss due to climate change.
A new study by RCSI University of Medicine and Health Sciences found that the circadian body clock influences immune responses to vaccines. The research discovered that the shape of mitochondria in dendritic cells changes throughout the day, impacting their ability to break down vaccines.
Researchers at Tokyo University of Science have developed a unique 3D COF with scu-c topology, exhibiting efficient gas adsorption and drug delivery capabilities. The material has been shown to exhibit excellent hydrogen and methane adsorption properties.
Researchers found galectin-3 upregulation in macrophages following cardiomyocyte-derived IL-18, promoting cardiac inflammation cascades and fibrosis. A galectin-3 inhibitor effectively blocks cardiac injury one day after β-adrenergic insult.
A study found that over 25,000 adult deaths in the US between 1999 and 2019 listed cerebral palsy as the underlying cause, often paired with respiratory illness. The incorrect labeling hinders understanding of how cerebral palsy interacts with other conditions.
Researchers found that using portable home air purifiers improved markers of cardiovascular health in people with COPD. The study tracked participants' lung and heart health over six months, revealing a 25% increase in heart rate variability among those using active HEPA and carbon filters.
A study published in the Astrophysical Journal reveals a strong correlation between cosmic ray counts and the solar cycle at Mars and Venus. The research found that cosmic rays are suppressed during peak solar activity, highlighting the importance of understanding these interactions for future robotic missions and human exploration.
A group of biologists is exploring the potential of seed banks, frozen zoos, gene editing, and assisted gene flow to create second chances for species affected by climate change. By understanding local adaptation strategies, conservationists can design more effective conservation actions.
A systematic review and meta-analysis of 122 US-based COVID-19 clinical trials found female participants were underrepresented in treatment trials, while Asian and Black participants were underrepresented in prevention trials. Hispanic or Latino participants were overrepresented in treatment trials.
The American Heart Association has added a new $4 million grant to its $24 million Strategically-Focused Research Network (SFRN) on the Science of Diversity in Clinical Trials. The new center, led by researchers at Johns Hopkins University and Morgan State University, aims to identify ways to increase participation and recruitment of p...
Researchers modeled how genetic changes affecting protein synthesis speed can lead to misfolding and altered activity levels in proteins. This finding suggests the importance of kinetics alongside sequence for determining protein structure and function, with potential implications for fields such as biopharmaceutics and medicine.
The Southern Hemisphere is stormier than the Northern due to ocean circulation and mountain ranges in the Northern Hemisphere. Since the 1980s, storminess has increased in the Southern Hemisphere, while the Northern Hemisphere has seen negligible changes.
Researchers found that the NIH Toolbox Cognition Battery is a promising option for measuring cognitive change in people with intellectual disability. The study shows that the test is sensitive to developmental changes in children, teens, and young adults, which can help guide effective interventions.
Researchers at Brookhaven Lab and PNNL develop a new method to study the solid-electrolyte interphase in lithium metal batteries, revealing its convoluted chemistry. The team's findings provide a foundation for building more effective battery cells with higher energy density.
Researchers found that a one-year increase in retinal age was associated with a 10% higher risk of incident kidney failure over 11 years. Retinal age gap, a non-invasive biomarker based on retinal imaging, may help identify people at elevated risk for kidney failure.
A new app uses customized playlists to console, relax, and uplift users, aiming to improve emotional states. The app's creators found that relaxing and uplifting methods can significantly move listeners from negative to more positive emotional states.
A new study presents early data from an online prevention strategy aimed at reducing the risk of firearm injury and death in rural areas. The effort tailors messages about safe firearm storage and teen firearm suicide to a rural audience, with strong engagement reported by 86% of parents.
A new study shows that paying cash to people with obesity for losing a specific amount of weight works better than offering free tools like weight-loss programs and wearable fitness trackers. Incentives tied to actual weight lost were most effective in the short term, while goal-focused financial rewards performed better in the long run.
A new 16-week trial will test whether a medication that targets gut bacteria can improve irritability in teenagers with autism spectrum disorder. The study aims to reduce the entry of certain substances produced by gut bacteria into the brain via the bloodstream, potentially reducing traits of irritability and anxiety.
Researchers at the University of Bristol have created a new technique to construct rare molecules found in Bahamian sediments, which could lead to cheaper and more accessible treatments for diseases. The breakthrough reduces the production time of these complex molecules from over 20 steps to just 14.
A national US study found a 245% increase in child marijuana abuse and a decline in alcohol abuse over the past 20 years. The study tracked intentional misuse and abuse reported to the National Poison Data System from 2000 to 2020, revealing over 338,000 instances of child abuse or misuse.
Researchers analyzed over 4,500 documents to understand fungal dispersal across spatial scales. They identified four scales of movement, from microscopic to landscape, and found that climate change affects where fungi reside. More data is needed to understand the biodiversity of fungi and their movement in ecosystems.
Research published in Nature Food suggests that small pelagic fish like herring and sardines are abundant and affordable sources of nutrients, particularly selenium, omega-3 fatty acids, and zinc. The study found that these fish could help close nutritional gaps in sub-Saharan Africa and other low- and middle-income countries.
A Northwestern Medicine study found that online platforms are offering therapies to men who don't meet guidelines for testosterone deficiency, while failing to convey the risks and benefits of therapy. The study recommends seeing a provider with expertise in hypogonadism for accurate care.
A Swansea University study finds that a simple therapeutic method, counterconditioning, can overcome pandemic-related fear and avoidance by pairing pleasant stimuli with Covid-19-relevant images. The online counterconditioning technique led to diminished threat expectancy and reduced avoidance in participants.
Physicist Ferah Munshi is testing self-interacting dark matter with galaxy formation simulations to test CDM and SIDM paradigms. The study aims to reproduce diverse galaxy densities and shapes, shedding light on the universe's smallest-scale mysteries.