The National Cancer Institute has approved atezolizumab, an immunotherapy drug, for the treatment of adults and children with advanced alveolar soft part sarcoma. The approval is based on a phase 2 trial that showed significant tumor shrinkage in about a third of patients.
Researchers have successfully demonstrated that human brain organoids implanted in mice can establish functional connectivity and respond to external sensory stimuli, including visual cues. The breakthrough uses a combination of transparent graphene microelectrode arrays and two-photon imaging, enabling real-time observation of neural ...
A recent study at the University of Helsinki found that singing-based group rehabilitation can increase communication and speech production in stroke survivors, while also reducing social isolation. The study's results suggest that this type of rehabilitation could be a valuable addition to existing aphasia treatment protocols.
Researchers developed a mathematical model of bacterial movement that includes cell division and death. The model predicts bacteria can form colonies through travelling waves of concentrated 'packages' of bacteria.
A team of researchers from top institutions has launched the SenNet Consortium to study senescent cells, which may contribute to aging and age-related diseases. The study aims to identify potential therapies that can remove senescent cells and improve human health as we age.
The study identifies four key drivers of political violence in the United States: toxic polarization, identity-based ideologies, erosion of democratic norms, and disinformation. These drivers contribute to increased acceptance of political violence and undermine democratic institutions.
A new form of thin-film device technology using alternative semiconductor materials could contribute to a more sustainable IoT. Wireless power harvesting from the environment using photovoltaic cells and RF energy harvesters is being explored.
A study found nearly one-fourth of breast cancer patients experience reconstructive burnout, characterized by incomplete or abandoned breast reconstruction. Risk factors include radiation therapy, higher body mass index, and tissue expander complications.
A recent study found that the APOBEC3G enzyme can cause numerous mutations in bladder tumor cells, leading to increased malignancy and mortality. The research suggests that this enzyme could be a potential target for cancer treatment strategies.
Researchers demonstrated high-visibility quantum interference between two independent semiconductor quantum dots, an important step toward scalable quantum networks. The observed interference visibility is up to 93%, paving the way for solid-state quantum networks with distances over 300 km.
Researchers developed a transparent temperature sensor that can measure rapid temperature changes in less than a few milliseconds. The sensor uses the thermoelectric effect and achieves high transparency, making it suitable for various photothermal bioengineering and medical applications.
Researchers identified seven exotic igneous clasts in Chang'e-5 samples, providing critical information about the Moon's lithological diversity and regolith gardening process. The findings indicate that there are still unknown geological units on the moon, which may aid future lunar exploration missions.
Researchers found that pyrethroid derivatives induce autophagy, increase reactive oxygen intermediates, and alter membrane fluidity in human primary cells. These findings suggest a potential risk for malignancies and highlight the need for further investigation into pyrethroid-related cancer risks.
A study of 578 mental health apps found that most offered basic features like psychoeducation and goal tracking, but fewer innovative features like biofeedback or specialized therapies. Privacy concerns remained a significant issue, with app popularity metrics providing little help in identifying more private apps.
During the COVID-19 pandemic, state-level cigarette sales varied significantly across the US. The analysis found lower per capita sales in eight states and higher sales in 22 states compared to expected levels. These findings may be related to differences in state responses to the pandemic and tobacco control policies.
Researchers at Hokkaido University identify a nerve pathway in the brain stem involved in processing rewarding and distressing stimuli, opposing a previously identified pathway. This finding could lead to developing drug treatments for mental disorders like addiction and major depression.
Researchers discovered a new situation where vertical perception is compromised - when the body pitches and moves at the same time. In real-world experiments on Hong Kong's Peak Tram, they found that participants misjudged their perceived verticality by up to 10 degrees.
Researchers found a significant association between restricting abortion access and increased suicide rates among women of reproductive age. The study's findings have clinical, policy, and ethical implications, highlighting the need for healthcare providers to approach suicide risk classification in this demographic differently.
Transition metal nitrides (TMNs) show high intrinsic electrocatalytic activities on hydrogen evolution reaction (HER), thanks to their unique electronic structures and properties. Recent strategies like facet, alloying, doping, vacancy, heterostructure, and hybridization have improved TMN performances.
Researchers reveal how cells use their sense of touch to make vital decisions during embryogenesis, including testing the surroundings and sensing tissue architecture. The study provides new insights into cell communication and may lead to the development of more robust synthetic tissues in tissue engineering.
Scientists at UC San Diego School of Medicine identified distinct patterns of cytokine and granzyme expression in tissue-resident memory T cells, highlighting their complex biology. These findings pave the way for a new branch of precision therapeutics targeting infection, cancer, and autoimmune diseases.
Researchers from Okayama University found that Actinidia arguta (Sarunashi) juice and its component isoquercetin inhibit lung cancer development in mice, accelerating DNA repair and suppressing Akt-mediated growth signaling. The study suggests Sarunashi juice as an attractive candidate for chemoprevention.
Researchers at the University of Basel have calculated that Andermatt-Sedrun-Disentis ski resort's 100-day ski season is unlikely by 2100 due to warmer winters. Water consumption for snowmaking will increase significantly, with an average winter requiring 540 million liters of water.