Researchers found that muscle wasting severity is related to the type, size and location of tumors in mice, with different tumors causing varying levels of wasting. The study's findings have crucial implications for understanding how different cancers affect muscle mass and developing effective treatments.
A new study by researchers at the Swiss Institute of Allergy and Asthma Research found that commercial dishwashers' rinse agents can damage the gut's epithelial barrier, leading to chronic diseases. The study used human intestinal organoids and analyzed the effect of detergents and rinse aids on gut cells.
Early stage clinical studies confirm 40Hz sensory stimulation is safe, with no serious adverse effects. The therapy also showed significant neurological and behavioral benefits, including improved brain activity, reduced brain atrophy, and better sleep patterns.
Researchers demonstrate the expanded use of a computational method called AFIR, predicting pericyclic reactions with accurate stereoselectivity based on target product molecule information. The technique successfully handles molecules up to 52 atoms and predicts stereochemistry for reactions that break Woodward-Hoffman rules.
The study found that Charisma Virtual Social Training improved recognition of emotions, inference of social intentions, understanding of perspectives, and description of pro-social qualities in youth. The research demonstrated significant benefits regardless of delivery model or ASD diagnosis status.
Through its Integrated Pest Management program, WVU Extension educates growers on safe techniques, including barriers, insect traps, and predatory insects. The goal is to reduce pesticide use and promote environmentally friendly practices.
UC San Diego researchers have developed a self-powered ingestible biosensing system that provides continuous monitoring of gut metabolites, unlocking new understanding of intestinal health and its impact on human health. The battery-free sensor is powered by glucose and can measure glucose levels in the small intestine for up to 14 hours.
Scientists at the University of York have identified an enzyme that makes Leishmania infantum parasite resistant to miltefosine, a medication used to treat visceral leishmaniasis in Brazil. The discovery opens up potential for developing a blood test to predict patient outcome and tailor treatment to individual patients.
A new study found that 1 in 10 women without pre-existing hypertension may develop it up to a year after childbirth, highlighting the need for extended blood pressure monitoring. Mothers at highest risk include those over 35, current or former smokers, and C-section deliveries.
Researchers at the University of Ottawa have developed a new technique to differentiate the mirror images of a chiral molecule, a problem that was believed to be unsolvable for nearly 20 years. The team used linear polarized helical light beams to enhance sensitivity and observed differential absorption in achiral molecules.
Researchers designed a wearable smart device for cows that captures kinetic energy from movement and uses it to power smart ranch technology. The device can be powered by even small movements, such as neck swaying or walking, and stores energy in a lithium battery.
Johns Hopkins researchers have developed a three-dimensional organoid model derived from human tissue to study gastroesophageal junction (GEJ) cancer. The dual knockout of genes in the model has identified key biological targets for treating GEJ cancers with existing drugs.
Researchers at Stockholm University discovered that plants use different combinations of LACCASEs to create specific lignin chemistries, allowing them to resist climate challenges. This adaptation enables plants to grow tall and survive extreme weather conditions.
A study conducted in Brazil reveals that only 75.8% of under-fifteen children in São Paulo have antibodies against measles, falling short of the ideal 94% target to prevent outbreaks. The finding is a warning sign that Brazilian children are not achieving herd immunity, making them susceptible to infection.
For adrenal lesions evaluated by single-phase dual-energy CT, fat fraction had significantly higher sensitivity than virtual noncontrast attenuation at both clinically optimal threshold and traditional ≤10 HU threshold. Fat fraction-derived metrics can help definitively diagnose incidental adrenal lesions as adenomas.
Researchers discovered a genetic mutation in the THBS1 gene linked to severe childhood glaucoma, which may improve disease screening and treatment. The finding could lead to earlier diagnosis and more targeted therapies for children at risk.
Researchers identified various feeding behaviors in nurse sharks, including vertical and ventral feeding, as well as 'pectoral positioning' where they flex their pectoral fins. This adaptable behavior suggests nurse sharks can thrive on different prey across various habitats.
A study found that managers demonstrate explicit and implicit bias toward marginalized groups, with biases varying by occupation and type. The researchers used data from Harvard University's Project Implicit to assess biases among managers and compared them to those in other occupational designations.
A Cardiff University-led study found that children with type 1 diabetes who struggle to manage their blood glucose levels are absent for 15 more sessions per year, compared to 7 for those with the healthiest levels. These absences result in lower educational attainment, including five grades lower in GCSEs.
A new study reveals ketamine dramatically changes neuronal activity patterns in the cerebral cortex, turning off active neurons and turning on silent ones. This switch in brain activity may impact our understanding of ketamine's antidepressant effects and future research in neuropsychiatry.
A new study found that postpartum visit attendance declined by 5.8% during the pandemic, with uninsured women, Black women, and women under 19 facing the largest decreases. The study highlights the need to address health policy and system challenges to reduce ongoing disparities in postpartum care.
Research from Rutgers University suggests that high-dose green tea extract may cause liver damage in individuals with specific genetic variations. The study found that two genetic variants, COMT and UGT1A4, were associated with increased liver stress after a year of consuming the supplement.
Professor Jan Grabowski's research on the Holocaust reveals untold stories of average citizens' roles in persecution. His work shows that rural counties contributed to terror, and non-Jews took initiative against Jewish communities.
A recent study led by the University of Nevada, Reno and the Pan American Health Organization suggests that the adoption of front-of-pack nutrition labeling can help reduce poor-nutrition related non-communicable diseases in the region. Improved FOPNL systems have been associated with improved diet quality and reduced risk of NCDs.
Researchers found that small pelagic fish, such as herring and sardines, are a cheap source of nutritious seafood. These fish can provide essential micronutrients like iron, zinc, and omega-3 fatty acids to vulnerable populations in low-income countries.
A new study reveals that children who survive firearm injuries are more likely to develop mental health diagnoses, particularly stress-related conditions and substance misuse issues. The research found that 35% of firearm-injured kids received a new mental health diagnosis in the year after the incident.
New research reveals that healthy newborn babies' gut bacteria do not contain multi-drug resistant strains of common hospital pathogens. The study found multiple synergistic relationships between different bacteria, which could potentially be harnessed to outcompete resistant or harmful bacterial strains.
A Queen Mary University of London study found that only 75% of children receive the first MMR vaccine on time, with poorest neighborhoods most affected. The researchers call for increased investment in vaccination services to ensure all London children are protected from measles.
A new study found that early-life experiences can alter gene expression in fruit flies, leading to improved health and extended lifespan. The researchers discovered that changes in chromatin packaging persisted across the lifespan, counteracting normal aging processes.
Researchers found that coral microbiomes shed nutrient-loving and pathogen-associated microbes while increasing nitrogen-fixing microbes during dormancy. This restructuring helps maintain the coral's microbial community structure.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
A study published in BMJ Open found that adolescents with hypermobile joints are at a higher risk of developing depression and anxiety. Researchers discovered that psychiatric symptoms were more severe among hypermobile participants, highlighting the need for targeted support and treatment.
A study published in PLOS Medicine suggests that primary vaccination provides moderate protection against Omicron infection regardless of prior infection history. However, the additional benefit of an original booster dose is unclear in people who have previously experienced COVID-19 infection.
Researchers developed an integrated approach to accelerate drug discovery by combining complex datasets from two screening platforms and next-generation metabolomics analysis. The new framework identified known compounds, confirmed mechanisms of action, and discovered novel compounds with unique biological signatures.
A study found that all types of alcoholic beverages increase cancer risk, with higher awareness for liquor than wine or beer. The researchers suggest educating the public about alcohol's link to cancer to prevent excessive use and related health issues.
A new study maps the global landscape of antimicrobial resistance, revealing surprising transmissions in Sub-Saharan Africa and highlighting the need for tailored strategies to combat resistance. The research, which analyzed sewage samples from 243 cities in 101 countries, found that resistance genes are more frequently transmitted acr...
Inequalities in sex and gender, access to antiretroviral drugs, and inadequate funding hinder global efforts to combat AIDS and other pandemics. UNAIDS Executive Director Winnie Byanyima and Deputy Director Matthew Kavanagh emphasize these disparities as critical obstacles to effective pandemic response
Research suggests that long COVID patients share similar lingering negative effects on physical, mental, and social well-being with individuals who have other illnesses. The study found moderate-to-severe residual symptoms in 40% of COVID-positive participants and 54% of those who tested negative.
The latest research evidence suggests that inflammation may play a causative role in Parkinson's disease. Multiple independent studies have provided evidence of the involvement of central and peripheral immune and inflammatory processes in PD, with increasing evidence suggesting an association with autoimmune conditions.
Research found that while broad T-cell response against SARS-CoV-2 spike protein is currently protective, recognition of seven out of ten T-cell targets mutated in COVID-19 variants is impaired. The study suggests ongoing mutation could lead to decreased overall immune system protection.
Researchers identified methane inhibitors and dietary changes that can decrease emissions with no negative effect on milk production. Increasing digestible forage intake or using the red macroalga Asparagopsis taxiformis may also be effective mitigation strategies.
Research from Aarhus University found that melting glaciers release around 10,000 microorganisms per millilitre of meltwater, leading to estimated annual releases of over 100,000 tonnes of carbon-dense microorganisms to surrounding ecosystems.
Researchers have identified optimal blood tests to detect Alzheimer's disease at its earliest stages. The study found that phospho-tau217 is a reliable marker for monitoring disease progression and selecting individuals for novel trials.
A study using a mouse model found that over-expression of the Esr1 gene increased the risk of developing estrogen receptor-positive breast cancer in older women. Giving anti-hormonal drugs to mice with Esr1 over-expression lowered or reversed this risk.
Researchers found viruses with Omicron-specific mutations in COVID-19 patients in six African countries two months before the variant was detected. The study suggests that Omicron emerged gradually, evolving from existing human immunity, and spreading rapidly across Africa before global detection.
Researchers developed a new approach to analyze coercivity in soft magnetic materials using machine learning and data science. The method condenses relevant information from microscopic images into a two-dimensional feature space, visualizing the energy landscape of magnetization reversal. This study showcases how materials informatics...
The updated guideline provides recommendations on managing HIV infection, including changing antiviral regimens, use of preexposure prophylaxis, care for pregnant persons with HIV, people aging with HIV, and those with substance use disorder. The guidelines also address new challenges such as COVID-19 and monkeypox virus infection.
Researchers developed a transparent thermally tunable microwave absorber using patterned vanadium dioxide film, achieving high optical transparency and large modulation depth. The absorber exhibited near-unity absorption at 15.060 GHz and temperature-tunable performance.
Researchers developed a method to measure overall fitness using wearable devices, outperforming current consumer smartwatches and fitness monitors. The model uses machine learning to predict VO2max during everyday activity, providing accurate predictions based on heart rate and accelerometer data.
Scientists used AI-driven PandaOmics platform to analyze gene expression datasets from DNA repair diseases, identifying biomarkers associated with treatment response. The study focused on genes that stratify cancer patients by survival outcomes, providing potential targets for personalized therapies.
A recent study published in Geriatrics found that age, education, social network, pain, and depression are significant predictors of physical activity in older adults. The findings suggest that modifying these factors through targeted interventions can increase physical activity levels.
A new study suggests that estrogen-blocking drugs can not only prevent breast cancer but also reduce the risk of dying from the disease. Researchers used computer models to determine the lifetime benefits and harms of these treatments for women at high risk, finding a significant impact on mortality.
Researchers discover a shared genetic basis between fibromuscular dysplasia (FMD) and abdominal aortic aneurysms (AAA), with males more likely to develop AAA when a family member has FMD. The study suggests that screening for AAA in male relatives of patients with FMD may be beneficial, along with established guidelines.
Researchers at UCLA Health have made significant breakthroughs in understanding deadly brain cancer and the role of housing interventions. A study found a cancer vaccine to be highly effective in treating glioblastoma multiforme, a nearly lethal brain cancer. Additionally, a survey highlighted the need for increased diversity in gastro...
A Phase 1 clinical trial presents promising results for a broadly neutralizing antibody (bnAb) HIV vaccine, inducing bnAb-precursor responses in 26 of 27 vaccine recipients. The germline-targeting immunogen was safe and feasible, supporting the concept of germline targeting for HIV prevention.
A team of researchers developed a neural network that can analyze digital biopsy images to diagnose breast cancer, identifying the presence of PD-L1 protein. The AI system outperformed human pathologists in 70% of cases, with high accuracy rates and potential for personalized medicine.
Researchers discover how E. coli bacteria manipulate the immune system to cause ileocolitis in susceptible individuals. The study reveals the key role of agr2-associated ER stress in promoting dysbiosis and triggering CD103+ dendritic cell IL-23-dependent inflammation.
Researchers discovered that synchronized neural oscillations in the right hemisphere of the brain induce empathic behavior in mice, allowing them to perceive and share each other's fear. The study identified the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and empathic responses.
Researchers developed a new method to target and treat visceral adiposity using positively charged P-G3 nanomaterials, which inhibit unhealthy lipid storage in enlarged fat cells. This approach also rejuvenates healthy fat cells, promoting metabolically healthy fat cell formation.
Researchers from City University of Hong Kong developed a new ultra-stable hydrogen evolution reaction electrocatalyst based on two-dimensional mineral gel nanosheets. The catalyst exhibits excellent electrocatalytic activity and long-term durability, with an overpotential of only 38.5 mV at 10 mA cm−2.