Articles tagged with Regenerative Medicine
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
Researchers developed smart 4D-printed vascular stents that expand naturally at body temperature, eliminating the need for external heating. The stents balance mechanical flexibility and radial strength, demonstrating long-term biomechanical compliance.
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
A research team has developed a way to produce corticospinal-like neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury. The study uses a multi-component gene-expression system called NVOF to precisely fine tune regulatory signals, resulting in mature neurons with distinct characteristics.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
Researchers have shown that human hearts can regrow muscle cells after a heart attack, paving the way for new treatments to reverse heart failure. The discovery was made possible by pioneering techniques that use living tissue samples taken from patients during bypass surgery.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
A Korea University study successfully mimics heart mechanics in organoids using three-dimensional magnetic torque, enhancing cardiac differentiation, maturation, and vascularization. This breakthrough could improve drug safety testing by providing more accurate human-relevant models for cardiotoxicity screening.
Researchers at Sanford Burnham Prebys found that transplanted stem cells develop neurons with unique codes to navigate and form connections in the brain. These codes guide the growth of axons and explain why most neurons of a particular subtype send axons to specific brain regions.
A Northwestern University study found an injectable regenerative nanomaterial helps protect the brain during a vulnerable window after most common type of stroke. The therapy successfully crossed the blood-brain barrier and reduced brain damage, showing no signs of side effects.
Researchers discovered subtypes of chondrocytes that transform into bone-building cells, regulating bone growth and vascularization. The study found that these cells secrete Thbs4 to induce blood vessel formation, shedding insights for treating defective angiogenesis.
Recent studies by Brazilian scientists clarify key roles of STIP1 and Maspin in vital cellular processes, including embryonic development, cell communication, and tissue renewal. These findings contribute to cancer research, regenerative medicine, and understanding cellular homeostasis.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers at Terasaki Institute and Caltech will use stem cell-based models to identify factors influencing early human development. The goal is to gain insights into infertility, pregnancy loss, and developmental disorders.
Matricelf is manufacturing the world's first engineered nerve tissues for paraplegics, aiming to enable patients to walk again. The company partnered with Tel Aviv Sourasky Medical Center (Ichilov) to produce the implants in cleanrooms, meeting regulatory requirements.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
Scientists at Southwest Research Institute (SwRI) have successfully replicated induced Pluripotent Stem Cells (iPSCs) using a new application of their cell-expansion bioreactor. The bioreactor's unique geometry allows for the growth of large quantities of iPSCs, which can differentiate into any other cell type in the body.
The new approach uses lab-grown heart tissue made from reprogrammed adult stem cells, delivered through a tiny incision. In preclinical testing, the stem cell patch restored heart function and improved healing, offering a new way to repair damaged hearts.
The ISSCR and SCN are partnering to develop a global conversation on workforce development in regenerative medicine, examining current challenges and identifying skills gaps. The joint initiative aims to build the talent required for continued discovery and innovation in the field.
A new, fully degradable cranial clamp made from poly-L-lactic acid has been developed to address traditional fixation system drawbacks. The study compared its performance to Aesculap CranioFix through laboratory tests and a clinical trial involving 90 patients, showing improved safety and healing outcomes.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Researchers at Sanford Burnham Prebys have developed a new method to generate more and potent skeletal muscle progenitor cells. The study found that blocking the activity of Janus kinase 2 (JAK2) yields a twofold increase in cell yield, while also delivering more mature and effective cells for regenerative medicine treatment.
Global experts discuss the future of additive manufacturing in various applications, including bioprinting living tissues and creating smart consumer products. Researchers showcase advancements in machine learning, real-time sensing, and multi-material 3D printing.
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
Researchers at the Mayo Clinic have found that platelet-rich plasma (PRP) treatment can significantly improve genitourinary syndrome of menopause (GSM) symptoms in breast cancer survivors. After six months, GSM symptoms such as sexual function, urinary symptoms and quality of life improved, even among those taking estrogen blockers.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Christopher Chen, a renowned biomedical engineer, has been elected to the National Academy of Medicine for his groundbreaking contributions to cell and tissue engineering. His research may lead to lifesaving new treatments for disease, including heart attack cures and organ repairs.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
Researchers discovered a molecular circuit controlling AT2 cell fate plasticity, which could guide regenerative therapies for chronic lung diseases. The discovery highlights potential new targets for regenerative medicine and may lead to earlier detection and prevention of organ failure.
Researchers at the University of Cambridge have developed a new lab-grown human embryo model that replicates early human development, including the production of blood stem cells. The 'hematoids' model mimics the natural developmental process, offering potential medical advances in screening drugs and studying blood disorders.
Denis Evseenko and Toby Maher are developing a regenerative drug to block cells that promote fibrosis in the lungs, aiming to slow or reverse IPF damage. The team plans to test the safety and therapeutic potential of their drug-like molecules in animals and human cells.
Stem cell transplantation has been shown to reverse stroke damage in mice by regenerating neurons and restoring motor functions. The treatment also improved blood-brain barrier integrity, reduced inflammation, and promoted new blood vessel formation.
Researchers at UMC Utrecht developed a new AI-powered printer called GRACE that can print implantable tissues with improved cell survival and functionality. The printer uses computer vision and laser-based imaging to design and print complex structures, including blood vessels and cartilage layers.
Researchers create a device that prints bone grafts directly onto fractures and defects using a modified glue gun. The tool enables rapid creation of complex implants without pre-fabrication and demonstrates high structural flexibility, anti-inflammatory properties, and natural bone regrowth.
Researchers developed novel artificial bone scaffolds with high deformation recovery capabilities, exceeding those of natural bone and conventional metallic scaffolds. These scaffolds allow for flexible adjustments of properties like strength and modulus to meet specific implantation site requirements.
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
Aging cells disrupt bone renewal and repair processes, leading to weak bones and joint degeneration. Cellular senescence and inflammation are major drivers of skeletal decline, while senolytics and emerging therapies offer promising new paths for treatment.
Researchers developed a novel 3D printing technique called IPS 3DP to create personalized implants with specific mechanobiological properties. The method enables the creation of structurally complex hydrogels with hierarchical microstructures and strain-stiffening behavior, paving the way for advanced biomedical applications.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
The study uses Rapid Precision Run-On Sequencing (rPRO-seq) to uncover molecular drivers of cellular differentiation, offering a paradigm shift in understanding regenerative therapies. The technique allows doctors to analyze patients' disease states and treatment response in real-time.
Scientists have developed a breakthrough method to grow human kidney organoids from tissue stem cells, mirroring fetal kidney development over months. The organoids can be used for research and testing of new treatments for kidney diseases.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers at Washington University in St. Louis have successfully induced a reversible torpor-like state in mice using focused ultrasound, offering a novel strategy for medical interventions. This technology aims to reduce energy demand and preserve organs for transplantation, promising to transform medicine.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
Researchers at RCSI University of Medicine and Health Sciences have developed a 3-D printed implant that delivers electrical stimulation to injured areas of the spinal cord, enhancing nerve cell growth. The study has shown promising results in lab experiments and may enable new medical devices for traumatic spinal cord injuries.
Researchers at Duke University Medical Center discovered stress-induced regenerative capabilities in human ankle cartilage, which shares similarities with salamander's ability to regenerate severed limbs. This finding provides a new potential framework for joint repair and may lead to optimizing innate restorative function.
GeniPhys has received FDA clearance for its self-assembling collagen scaffold, Collymer Self-Assembling Scaffold (SAS), which supports cellular infiltration and vascularization. The technology is indicated for various wound types and anchors a growing intellectual property portfolio with nearly 20 issued or pending patents.
Researchers found that human stem cells can differentiate into bone cells simply by being squeezed through narrow spaces. This discovery could lead to the development of simpler and safer regenerative therapies by using physical signals instead of chemical cues. The study's findings have broader implications, including potential applic...
Scientists successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology. The AT2-like cells were generated in just 7 to 10 days, a significant reduction compared to conventional methods.
Hideyuki Okano has been elected President of the International Society for Stem Cell Research (ISSCR), an organization dedicated to promoting excellence in stem cell science. He will champion inclusive excellence, advance discovery, and ensure that the transformative promise of stem cell science benefits the world.
Scientists have created a novel method to distinguish between healthy and senescent cells using electric fields, marking a fresh start in ageing research. The frequency-modulated dielectrophoresis (FM-DEP) technique is label-free, rapid, and easy to apply, allowing for the characterization of cell type by measuring the cutoff frequency.
Researchers at Tufts University created Anthrobots by growing human cells in a novel environment, revealing that these tiny organisms can express ancient and embryonic genes without genetic manipulation. This process resets the cellular aging clock, making the Anthrobots biologically younger than their original adult cells.
Professor Garry Duffy joins RCSI with a unique combination of institutional knowledge and fresh leadership perspective, focusing on integrating excellence in health sciences education with innovative patient-centred research. He aims to build on the university's heritage by enhancing anatomical education and pioneering research in rege...
Researchers developed a new method to study mechanical proteins, revealing that disrupting protein titin causes muscle disease. The technique allows for targeted analysis of protein mechanics, paving the way for new therapeutic strategies.
The new 3D-printed device, STOMP, enhances tissue-engineering methods by allowing for precise control over cell types and spatial arrangement. This enables scientists to model complex diseases and recreate natural habitats of cells, paving the way for advancements in biomedical research.