Articles tagged with Regenerative Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The new international doctoral programme, RAMP-UP, aims to improve regenerative medicine and ATMPs in Europe by training 55 doctoral students from academia, healthcare, and industry. The programme has the potential to revolutionise healthcare with advanced therapies for genetic diseases and cancers.
Scientists have developed a sugar-coated nanotherapy that effectively traps misfolded proteins, neutralizing their toxic effects on neurons. The treatment significantly boosts the survival of lab-grown human neurons under stress from disease-causing proteins.
Dr. Ali Khademhosseini, TIBI Director, receives the 2025 MRS Mid-Career Researcher Award for his groundbreaking contributions to biomaterials science and tissue engineering. His research has revolutionized engineered tissue constructs for drug discovery and regeneration.
A UC Riverside-led study found that adult stem cells rely on histone chaperones to maintain their regenerative capacity. The researchers discovered that disrupting these proteins can lead to specific changes in stem cell identity, potentially guiding them into desired cell types.
Researchers have characterised how dying cells contribute to the body's regeneration process, suggesting a new mechanism for tissue repair. The study found that cells released from necrosis play a role in signaling the production of other cells involved in controlling natural cell death and inflammation.
Assembloids offer a next-generation approach to 3D tissue modeling for human biology, integrating multiple organoids or diverse cell types. This enables the study of large-scale biological phenomena such as neural circuitry formation and immune-tumor dynamics.
The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.
Researchers discovered a molecular switch, FLI-1, essential for blood stem cells to enter an activated state. Transiently producing FLI-1 in quiescent adult mobilized bone marrow stem cells activates them, improving their ability to expand and restore the blood cell supply in a new host.
Researchers developed a hybrid bioink that maintains physiological properties of adipose tissue, promoting differentiation and regeneration. Bioprinted adipose tissues promoted wound healing in mice by inducing re-epithelialization, tissue remodeling, and blood vessel formation.
Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
A team from Tokyo Metropolitan University has successfully implanted myoblasts onto healthy muscle in mice using an extracellular matrix scaffold. This breakthrough treatment could treat ageing-related muscular atrophy without scarring, offering a promising avenue for regenerative medicine.
A new Northwestern Medicine study reveals that macrophages in newborns use a process called efferocytosis to produce thromboxane, which triggers the production of a bioactive lipid that signals heart muscle cells to divide and regenerate. This process is less effective in adults, leading to scar-tissue buildup and often heart failure.
Researchers at Fujita Health University have developed a novel therapy using mesenchymal stem cells to treat inflammatory eye diseases, reducing inflammation and promoting tissue repair. The study found that adMSC injections effectively reduced inflammation in mice with GVHD without long-term complications.
The ISSCR International Symposium will commemorate the 20th anniversary of iPSC discovery, highlighting breakthrough achievements and new research advances. The event aims to celebrate the transformative power of scientific curiosity and its potential to unlock cures for previously untreatable diseases.
A global team of scientists has made a groundbreaking discovery of a new skeletal tissue called lipocartilage, composed of fat-filled cells that provide super-stable internal support. This unique tissue has immense potential for treating facial defects, birth injuries, and cartilage-related conditions.
The Wake Forest Institute for Regenerative Medicine is part of a major undertaking to bring together experts from around the country to develop vision-restoring whole eye transplants. The project, valued at up to $56 million, aims to overcome technical, biological, and immunological hurdles in whole eye transplant.
A new bone regeneration scaffold, Qx-D, shows promise in treating infected bone defects by exhibiting broad-spectrum antibacterial activity against various bacteria. The scaffold also supports the adhesion and differentiation of key cell types involved in bone regeneration.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
A clinical trial showed that an antibody blocking Nogo-A protein improves motor function in patients with incomplete spinal cord injuries. The treatment led to significant improvements in voluntary muscle activation and everyday life functional independence. Further studies are needed to confirm the findings.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
A QUT-led study found that surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions for treating bone defects. The researchers surveyed 337 surgeons and 99 scientists, revealing a significant gap between their optimism about future advancements and the slow adoption of these innovations in clinical practice.
Researchers have developed a novel strategy for bone defect repair using flat silkworm cocoon fiber scaffolds functionalized with magnesium ions. These innovative materials exhibit enhanced biological performance and simplify scaffold preparation, paving the way for cost-effective and efficient bone regenerative therapies.
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
A team of researchers has identified an 18-digit code within a protein called Wnt7a that allows it to attach itself to exosomes, enabling targeted delivery of proteins throughout the body. This discovery has major implications for the development of new therapies for diseases such as Duchenne muscular dystrophy.
A new gene therapy has reversed the effects of heart failure in a large animal model by increasing blood pumping efficiency and dramatically improving survival rates. The therapy restored critical functions of heart cells and improved heart function on the microscopic level.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
Gary E. Wnek and Arnold Caplan recognized for their pioneering work in polymer science and stem-cell biology, respectively. Their research has generated significant economic impact and improved quality of life through inventions and innovations.
A USC Stem Cell study has identified key gene regulators that enable some deafened animals, including fish and lizards, to naturally regenerate their hearing. The researchers found a class of DNA control elements known as 'enhancers' that amplify the production of a protein called ATOH1, which induces sensory cells in the inner ear.
Advanced research identifies potential molecular instructions determining echinoderms' ability to adapt and regenerate tissues. The breakthrough could lead to new regenerative therapies and smart collagen-based biomaterials for treating human health conditions.
Professor Robert Fledrich has been awarded an ERC Consolidator Grant for his research on the regeneration of peripheral nerves. His team aims to investigate the conditions required for successful nerve regeneration, focusing on glial cells' metabolic dynamics and communication pathways.
The NSF-Piedmont Triad Regenerative Medicine Engine has awarded $2.5 million in grants to six innovative companies to support the commercialization of regenerative medicine products. The funding is expected to catalyze technological advancements, strengthen the local economy, and drive regional competitiveness.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
Researchers have successfully regenerated human epidermal keratinocytes into sweat gland-like cells using a combination of chemicals. These cells, called ciSGCs, restored thermoregulatory sweating and released bioactive factors to stimulate tissue repair in burned skin.
FetTech and Novex Innovations partner to expand regenerative medicine, creating jobs and stimulating local economic growth. The collaboration is part of the NSF-funded Piedmont Triad Regenerative Medicine Engine's ecosystem.
Researchers at Karolinska Institutet discovered that patients with heart pumps can regenerate heart muscle cells at a rate more than six times higher than in healthy hearts, offering new hope for therapies to stimulate the heart's ability to repair itself after damage.
Researchers at Karolinska Institutet have identified a molecule that can promote mucosal healing through tissue regeneration, potentially treating inflammatory bowel disease and colorectal cancer. The study found that activation of the Liver X receptor suppresses tumor growth in colorectal cancer, offering new therapeutic strategies.
The joint Ph.D. program will combine engineering immersion, commercialization training, and clinical shadowing to produce medical innovators capable of addressing unmet clinical needs. Students will be trained in translational thinking, engineering design principles, and entrepreneurship to develop technologies for precision diagnostic...
Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.
The ISSCR has developed a comprehensive Continuing Education (CE) course on stem cell-based therapies, covering fundamental biology, clinical trials, and patient communication. The open-access course aims to equip healthcare providers with accurate information, empowering them to navigate the complexities of this evolving field.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
Collymer is a regenerative collagen polymeric biomaterial designed for various medical applications. It can be engineered into materials with different shapes and properties to address unmet clinical needs in wound care, tissue reconstruction, aesthetics, orthopedics, and therapeutic cell delivery.
Researchers have made breakthrough in developing artificial kidney tissue from scratch, which could reduce the need for dialysis and transplantation. The study discovered a potential governor of kidney growth, tiny mechanical stress waves, to understand how nature builds the organ.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
Danielle Mor, a neuroscientist at the Medical College of Georgia, has been awarded $2.3 million to study the progression of Parkinson's disease through the use of C. elegans and innovative research approaches. Her goal is to understand how misfolded proteins spread from the gastrointestinal tract to the central nervous system.
A USC Stem Cell mouse study identifies a small subset of blood stem cells as the primary driver of immune aging. The researchers found that this subset overproduces innate immune cells, leading to an age-associated imbalance and increased disease risk. By targeting this subset, the study suggests a potential therapy to delay immune agi...
New research from Sharon Torigoe at Lewis & Clark College confirms the importance of low-affinity binding sites for Klf4 gene enhancers in naive-state pluripotent stem cells. This discovery advances scientists' knowledge of gene expression mechanisms and has implications for regenerative medicine and understanding human disease.
Researchers from USC and Caltech develop a new method to study hematopoietic stem and progenitor cells within the bone marrow without extracting them. This breakthrough could inform efforts to optimize bone marrow transplantation and provide insights into various health conditions, including cancer and heart disease.
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
Researchers discovered that DNA methylation patterns, like cellular memory markers, prevent reprogrammed cells from fully adopting new identities. This limitation limits the effectiveness of long-term treatments and therapies.
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
Researchers have discovered that administering regulatory T cells (Tregs) can enhance tissue healing, promoting bone volume, muscle growth, and skin wound closure. The key role of interleukin-10 (IL-10) in supporting tissue repair has also been identified.
Researchers will combine stem cell therapy with brain-computer interfaces to restore function to patients with brain damage. The goal is to create bidirectional connections between cultured brain cells and the living human brain.
Dr. Josephine Wu's project, OPTO-BIOPRINTING, aims to develop a novel platform for spatiotemporally guided tissue engineering using cellular self-assembly and light triggering. The goal is to create living organ replacements that can perform as well as native equivalents.
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
A new implant has been developed to encourage nerve cell repair after spinal cord injury. The implant uses electrical signals and a 3D-printed scaffold to bridge the gap and direct axons to grow back in the correct formation, promoting healing and recovery.
Holotomography offers a promising approach to biomedical research, providing high-resolution images of live cells and tissues at the organelle level. The KAIST research team has developed core technologies and demonstrated its applications in various fields, including regenerative medicine and cancer research.
The Wake Forest Institute for Regenerative Medicine is part of a new $18 million NSF initiative, COMPASS, aimed at enhancing global pandemic prediction and prevention capabilities. The collaboration will focus on understanding pathogen emergence and training the next generation of scientists to tackle this critical challenge.