Articles tagged with Regenerative Medicine
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
Collymer is a regenerative collagen polymeric biomaterial designed for various medical applications. It can be engineered into materials with different shapes and properties to address unmet clinical needs in wound care, tissue reconstruction, aesthetics, orthopedics, and therapeutic cell delivery.
Researchers have made breakthrough in developing artificial kidney tissue from scratch, which could reduce the need for dialysis and transplantation. The study discovered a potential governor of kidney growth, tiny mechanical stress waves, to understand how nature builds the organ.
Danielle Mor, a neuroscientist at the Medical College of Georgia, has been awarded $2.3 million to study the progression of Parkinson's disease through the use of C. elegans and innovative research approaches. Her goal is to understand how misfolded proteins spread from the gastrointestinal tract to the central nervous system.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
A USC Stem Cell mouse study identifies a small subset of blood stem cells as the primary driver of immune aging. The researchers found that this subset overproduces innate immune cells, leading to an age-associated imbalance and increased disease risk. By targeting this subset, the study suggests a potential therapy to delay immune agi...
New research from Sharon Torigoe at Lewis & Clark College confirms the importance of low-affinity binding sites for Klf4 gene enhancers in naive-state pluripotent stem cells. This discovery advances scientists' knowledge of gene expression mechanisms and has implications for regenerative medicine and understanding human disease.
Researchers from USC and Caltech develop a new method to study hematopoietic stem and progenitor cells within the bone marrow without extracting them. This breakthrough could inform efforts to optimize bone marrow transplantation and provide insights into various health conditions, including cancer and heart disease.
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
Researchers discovered that DNA methylation patterns, like cellular memory markers, prevent reprogrammed cells from fully adopting new identities. This limitation limits the effectiveness of long-term treatments and therapies.
Researchers have discovered that administering regulatory T cells (Tregs) can enhance tissue healing, promoting bone volume, muscle growth, and skin wound closure. The key role of interleukin-10 (IL-10) in supporting tissue repair has also been identified.
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
Researchers will combine stem cell therapy with brain-computer interfaces to restore function to patients with brain damage. The goal is to create bidirectional connections between cultured brain cells and the living human brain.
Dr. Josephine Wu's project, OPTO-BIOPRINTING, aims to develop a novel platform for spatiotemporally guided tissue engineering using cellular self-assembly and light triggering. The goal is to create living organ replacements that can perform as well as native equivalents.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.
A new implant has been developed to encourage nerve cell repair after spinal cord injury. The implant uses electrical signals and a 3D-printed scaffold to bridge the gap and direct axons to grow back in the correct formation, promoting healing and recovery.
Holotomography offers a promising approach to biomedical research, providing high-resolution images of live cells and tissues at the organelle level. The KAIST research team has developed core technologies and demonstrated its applications in various fields, including regenerative medicine and cancer research.
The Wake Forest Institute for Regenerative Medicine is part of a new $18 million NSF initiative, COMPASS, aimed at enhancing global pandemic prediction and prevention capabilities. The collaboration will focus on understanding pathogen emergence and training the next generation of scientists to tackle this critical challenge.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Researchers developed a bioactive material that successfully regenerated high-quality cartilage in animal models, promoting enhanced repair and growth of new cartilage containing natural biopolymers. The material's effectiveness was tested in sheep with cartilage defects, showing promising results for potential use in humans.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
Researchers discovered that transferring regenerative genes from simple organisms into fruit flies can suppress age-related issues and promote greater intestinal stem cell division. This breakthrough has implications for developing new strategies to rejuvenate stem cell function and extend healthy lifespans, particularly in humans.
The new journal Cell Organoid aims to push the boundaries of knowledge in organoid research, fostering innovation and collaboration across disciplines. The journal seeks to advance personalized medicine and therapeutic interventions by addressing ethical, technical, and standardization challenges.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
Researchers have developed a biodegradable scaffold to facilitate bladder tissue growth, reducing complications associated with traditional augmentation procedures. An implantable sensor also enhances patient monitoring, paving the way for improved bladder surgery outcomes.
Scientists designed ring-shaped proteins targeting growth factor receptors to control human stem cell development. The resulting vascular networks formed tubes, healed, and absorbed nutrients, offering a new approach to repairing damaged hearts and kidneys.
Researchers at UCLA have identified a key protein MYCT1 that enables blood stem cells to sense and interpret signals from their environment. The study's findings could lead to the development of methods to expand blood stem cells in a lab dish, making life-saving transplants more available.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
Researchers at Osaka Metropolitan University have discovered that plasma irradiation can accelerate tendon repair, showing faster regeneration and increased strength in lab rats. This breakthrough could lead to shorter treatment times and more reliable tendon healing for athletes and individuals with sports-related injuries.
The Ottawa Hospital is receiving a $59 million grant to boost Canada's capacity for life-saving biotherapeutics, including vaccines, gene therapies, and cell therapies. The funding will support the construction and operation of a world-class biomanufacturing facility at its new campus.
Researchers have discovered a repurposed cancer drug that can convert acinar cells into insulin-producing cells, which could provide a new avenue for treating diabetes. The treatment partially improved hyperglycemia and persisted without additional treatment in diabetic mice and non-human primates.
Researchers at UMSOM identified a modified sugar molecule that enhances human neural stem cells' proliferation and transition into neurons, improving brain function and reducing anxiety and depression. The study provides a promising proof of concept for regenerative medicine in patients with cardiac-arrest induced brain injuries.
A team at Baylor College of Medicine found that cyclophilin A helps HSCs retain their regenerative potential by supporting proteins with intrinsically disordered regions. This mechanism may contribute to the longevity of HSCs, which can maintain a relatively youthful profile throughout an organism's life.
Researchers at University of Cologne discover Cnicin, a plant-based compound that significantly accelerates axon growth in animal models and human cells. This breakthrough has the potential to treat paralysis and neuropathy by enabling nerves to regenerate more quickly.
Jos Malda receives ERC grant to crack cartilage code and create regenerative treatments. By studying cartilage 'organ-on-a-chip' models and animal cartilages, researchers aim to recreate the intricate internal structure of cartilage.
Caterpillars of the Carolina sphinx moth have an extraordinary ability to instantly change their hemolymph's material properties, turning it into a viscoelastic fluid that helps stop bleeding. This discovery has potential applications for developing new drugs for humans to create fast-working thickeners of human blood.
Scientists have uncovered a crucial step in the wound healing process that is disabled in diseases like diabetes and ageing, promoting tissue repair and regeneration. The discovery highlights the importance of sensory neurons in orchestrating the repair and regeneration of tissues.
Kessler Foundation and collaborators win $1 million prize for proof-of-concept study on tablet-type controller StimXS, designed to help individuals with spinal cord injuries manage autonomic functions. The team advances to Phase 3 of the NIH Common Fund's Neuromod Prize competition.
The USC CIRM ASCEND Center will offer organoids, single-cell analysis, and spatial transcriptomics services to the California research community. The center aims to facilitate collaboration, technology transfer, and a competent workforce in personalized medicine.
Scientists create a hydrogel system that can remember its shape, allowing them to control cell adhesion behavior. The elastic modulus of the hydrogel is adjusted by compressing it into different thicknesses at high temperatures.
Researchers successfully printed full-thickness skin with potential for hair growth in rats, paving the way for more natural-looking reconstructive surgery outcomes. The bioprinting technology uses fat tissue and stem cells to create layered living skin and contains hair follicle precursors.
Children's Hospital Los Angeles will develop innovative stem cell approaches to treat children and adolescents with recurrent solid tumors using CAR T-cell therapy. The new approach targets B7H3, an immune marker on cancer cells, to identify and destroy them.
Researchers discovered a sensor that switches on when cells want to regenerate and off when they are restored. Deactivating SOX9 can promote kidney recovery in injured kidneys, offering new targets for drug development and non-invasive biomarker discovery.
Researchers from IOCB Prague and Ghent University have developed 3D-printable gelatin-based materials that can be easily monitored using X-rays or CT scans. This improvement enables the tracking of implant biodegradation and mechanical failures, allowing for tailored clinical requirements.
Researchers create a simple method to instantly bond layers made of the same or different types of hydrogels using a thin film of chitosan. The new approach has potential to broadly advance new biomaterials solutions for multiple unmet clinical needs, including regenerative medicine and surgical care.
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
Researchers at USC Stem Cell lab discovered nearly 40 genes associated with immune cell production, including those related to diseases like myelodysplastic syndrome. The study found that gene activity was linked to specific levels of immune cell production, offering insights for improving bone marrow transplantation strategies.
Researchers discover a virus, MERVL, plays a critical role in embryonic development by regulating gene expression and ensuring smooth transition from totipotency to pluripotency. This finding has significant implications for regenerative medicine and artificial embryo creation.
Researchers from Niigata University discovered a novel macrolide-DEL-1 axis that drives bone regeneration in aging individuals. The study found that macrolide-based molecules increase DEL-1 protein expression and promote new bone formation, suggesting a potential therapeutic avenue for periodontitis-induced bone loss in humans.
Researchers have successfully genetically modified pluripotent stem cells to evade immune recognition, offering a viable path forward for pluripotent stem cell-based therapies. The study's findings suggest that these engineered stem cells could pave the way for new treatments for diseases such as Type 1 diabetes and macular degeneration.
A clinical trial found that stem cell-based therapy reduced daily hardship and improved physical and emotional health in patients with advanced heart failure. Patients who received the treatment had lower death and hospitalization rates compared to those on standard care.
A new stem cell treatment using mRNA technology from COVID-19 vaccines has shown promise in regenerating liver tissue, potentially reversing chronic and acute liver diseases. The treatment stimulates the natural repair mechanism of the liver by activating specific receptors on stem cells.
Researchers created multicellular bots from human tracheal cells that move across surfaces and promote healing of damaged neurons in a lab dish. The discovery could lead to new therapeutic tools for regeneration, healing, and disease treatment using patient-derived biobots.
Scientists at University of Toronto and Sinai Health created transplants with genetic modification, persisting long-term in mice without immune suppression. This breakthrough may transform cell therapies for incurable diseases, making transplantation safer and more widely available.
Researchers at RCSI University of Medicine and Health Sciences have developed a material that can speed up bone healing while reducing the risk of infections. The implant combines antimicrobial treatment with gene therapies to repair bone and prevent infection.
Researchers have developed additively manufactured Ti-Ta-Cu alloys that exhibit improved biocompatibility and bacterial resistance, making them a promising alternative to traditional Ti6Al4V implants. The alloys were found to display remarkable synergistic effects in improving both in vivo biocompatibility and microbial resistance.
Researchers at Rensselaer Polytechnic Institute have successfully created hair follicles in human skin tissue using 3D-bioprinting techniques. This innovation has potential applications in regenerative medicine, drug testing, and understanding the complex interactions between skin and topical products.
Researchers from Tsinghua University provide an overview of biofabrication methods for single-cell feature building blocks to reconstruct engineered living systems. The techniques aim to replicate natural tissues with precise control over microenvironment and structure, benefiting biomedicine applications.