Articles tagged with Antibiotics
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A study by Anglia Ruskin University has identified potentially dangerous Pseudomonas bacteria in 21% of wild bird faeces collected from locations near the River Cam. The bacteria, which can be passed on to humans through cross-contamination, were resistant to multiple antibiotics.
A rapid same-day test has been developed to identify secondary infections in COVID-19 patients on intensive care, allowing for targeted antibiotic treatment and reduced risk of antimicrobial resistance. The test uses nanopore sequencing technology to analyze bacterial and fungal pathogens present in patient samples.
Scientists at the University of Southampton have created nanoparticles that can target and kill deadly bacteria hiding in human cells. The breakthrough could lead to a new treatment method using injectable or inhalation-based antibiotic-laden capsules, potentially saving thousands of lives annually.
A new study found that regular antibiotic treatment with penicillin significantly reduced the risk of underlying rheumatic heart disease progression in children and adolescents. Early screening was critical in preventing serious disease progression and death in young children.
A new study found that low-dose CT scans are as accurate as standard-dose scans in diagnosing appendicitis and differentiating between uncomplicated and complicated cases. This breakthrough could lead to reduced radiation exposure for young patients, improving treatment outcomes.
Research identifies way of using nanoparticles to target and disrupt bacterial cells, making them more susceptible to standard antibiotic treatments. Laboratory studies show a strong effect in killing a range of bacteria, including some linked to hospital-acquired infections.
A new study found that heat and antibiotics alone and in combination degrade soil microbe efficiency, resilience, and ability to trap carbon. This could diminish soils' resilience to future stress and exacerbate climate change effects.
Researchers at Penn discovered a new suite of antimicrobial peptides, hidden within the human genome, which showed promising natural antibiotic potential. The peptides displayed antimicrobial activity against various pathogens, including E. coli and staph infection-causing bacteria.
The need for new antibiotics is critical due to rising antibiotic resistance, which kills over 35,000 people annually in the US. Research by Harvard Medical School aims to develop better antibiotics by targeting essential bacterial proteins.
A new report highlights the alarming global impact of Group B streptococcus, which can lead to up to 150,000 infant deaths annually. Maternal vaccination is seen as a cost-effective solution to reduce this toll, with significant health benefits in all regions.
A new study reveals that iboxamycin effectively fights both gram-negative and gram-positive drug-resistant bacteria in mouse models. The researchers discovered the molecular mechanism that allows this drug to overcome resistance, which is important for developing new antibiotics.
A study published in The Lancet Infectious Diseases found that temocillin was effective in treating febrile urinary tract infections with fewer resistant bacteria. Temocillin acts specifically against E. coli and other intestinal bacteria, reducing the risk of treatment failure.
Scientists found ancient bacteria in permafrost resistant to streptomycin, spectinomycin, chloramphenicol, and tetracycline. Genome analysis revealed limited differences between ancient and modern strains, suggesting a potential threat to human health due to global warming.
Researchers revealed that β-lactam antibiotics like penicillin kill MRSA by forming small holes in the cell wall, which gradually enlarge and lead to bacterial death. This discovery provides new avenues for treatment developments against antibiotic-resistant superbugs.
A new research discovery at Monash University has found a way to make antibiotics more effective against 'superbugs' by attaching chemoattractants to antibiotics, enabling the recruitment of immune cells and improving killing ability. The findings have shown a 2-fold increase in effectiveness with lower doses.
Researchers have recorded the sharpest images of living bacteria, revealing a complex architecture that makes them harder to kill by antibiotics. The study found that bacteria with protective outer layers may have stronger and weaker spots on their surface.
The Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) trial found that nearly 7 in 10 patients with antibiotics avoided an appendectomy within three months. By four years, just under 50% had the surgery, suggesting both treatments are safe and valuable to patients differently based on unique symptoms and circumstances.
Researchers at Cornell University used machine learning to predict the spread of antibiotic resistance genes among bacteria, identifying potential networks of exchange and driving factors. The approach could help control the spread of antibiotic resistance and develop new targets for novel antibiotics.
Researchers at the University of Bonn discovered a novel resistance mechanism in Staphylococcus aureus, which protects the bacteria from vancomycin. By binding vancomycin to its cell wall, the strain prevents the antibiotic from reaching the membrane and killing the bacteria.
Researchers at Berkeley Lab have successfully engineered microbes to produce novel chemicals and developed a new technique for studying enzyme reactions in real-time. This breakthrough could lead to the production of sustainable fuels, pharmaceuticals, and renewable plastics.
A new study suggests that a novel treatment involving the administration of an enzyme that degrades neutrophil nets may prevent brain swelling and improve waste clearance in rats with bacterial meningitis. The treatment could be combined with antibiotics if needed.
A new hydrogel treatment kills drug-resistant bacteria, including MRSA, and induces the expression of naturally-existing antimicrobial peptides in human skin cells. The gel is non-toxic, biodegradable, and scalable.
Researchers at the University of Oklahoma have contributed to a study on a new antibiotic that may cure Lyme disease and eradicate its occurrence from the environment. The antibiotic, hygromycin A, targets the ribosomes of the bacteria Borrelia burgdorferi and shows promise in treating the disease.
Researchers from EMBL Heidelberg and University of Tübingen discovered that certain antibiotics, like tetracyclines and macrolides, can kill specific gut microbes. Combining antibiotics with non-antibiotic drugs may reduce collateral damage by preserving antibiotic activity against pathogens.
Researchers at the University of Exeter develop a new method to mimic microenvironments in the human body, overcoming a major obstacle to using phage therapy. The study finds that phage can effectively kill bacteria in these environments without promoting genetic resistance.
Researchers tested spider silk from seven species and found no signs of antimicrobial activity, casting doubt on previous reports. The team attributed methodological shortcomings to compromised studies, suggesting that the silk may serve as a physical barrier rather than an intrinsic antimicrobial agent.
Researchers at IOCB Prague have developed a novel antibacterial material called NANO-LPPO that can prevent infection and facilitate treatment of skin wounds. The material combines lipophosphonoxins with a nonwoven nanotextile, which releases active substances in response to bacterial presence.
A new study by Oxford academics found that approximately 20% of flies and cockroaches carry carbapenem resistance, while 70-80% carry extended spectrum cephalosporin resistance. Climate change could lead to a doubling of insect populations and an increase in the global spread of antibiotic resistance.
A large trial found that antibiotic amoxicillin has little effect on relieving symptoms in children with uncomplicated chest infections. The study also highlights the need for 'safety-netting' advice to parents, explaining illness course and when re-attendance may be necessary.
A team of engineers and biotechnologists has developed a biosensor that measures antibiotic levels in breath, mirroring blood concentrations. This breakthrough enables on-site, personalized dosing to minimize resistant bacteria strains.
A systematic review found that azithromycin reduced low birth weight and prematurity in Africa and Asia but didn't lower infant deaths or hospital admissions. The study suggests the potential benefits of this intervention on neonatal outcomes may be limited, highlighting the need for further research.
Researchers at Duke University developed an antibiotic coating that can be applied to orthopedic implants before surgery, eliminating the risk of infection. The coating, made from two polymers and an antibiotic, prevents bacterial colonization and can be personalized for individual patients.
A new study from Cornell University has found that the antimicrobial properties of certain stem cell proteins can effectively reduce the viability of methicillin-resistant Staphylococcus aureus (MRSA) in skin wounds. The treatment also stimulates the surrounding skin cells to build up a defense against the bacterial invader.
Scientists have developed a new therapy that combines bacteriophages with antibiotics to treat antibiotic-resistant infections, specifically targeting Mycobacterium abscessus. The treatment, using the bacteriophage 'Muddy', showed significant improvement in survival rates and severity of infections when paired with rifabutin, demonstra...
A study found that adding melatonin to vancomycin treatment significantly reduces acute kidney injury in hospitalized patients, alleviating oxidative stress and restoring kidney function. The findings could lead to larger therapeutic breakthroughs and pave the way for further clinical studies.
A randomized clinical trial found that yogurt containing Bifidobacterium lactis BB-12 protected against harmful changes in the gut microbiome after antibiotic administration. The study also showed that levels of beneficial short-chain fatty acid acetate returned to baseline within 30 days.
Researchers suggest that protecting the microbiome is crucial in preventing and fighting off infections with harmful, drug-resistant bacteria. By preserving a healthy balance of beneficial microorganisms, individuals can reduce their susceptibility to these types of infections.
Researchers at Tel Aviv University have created a system that enables the production of 'good' bacteria capable of eliminating 'bad' bacteria. This breakthrough technology uses a toxin injection system to target specific types and amounts of toxins, offering an alternative to antibiotics.
Researchers at UC San Diego School of Medicine are studying the impact of antibiotics on breast milk and infant health. The team will investigate how antibiotics alter the composition of breast milk and impact the infant microbiome, metabolome and immune response.
A mechanical engineering faculty-researcher at RIT is developing a microfluidic device to improve the detection of drug-resistant bacteria in blood, which can cause severe infection and death. The goal is to detect these strains early, allowing for prompt treatment and recovery.
Patients with nontuberculous mycobacterial disease are hospitalized sooner and more often than their age- and sex-matched counterparts, according to a study published in CHEST. The risk is higher for people with compromised immune systems or damaged airways.
Researchers found that human antibiotic use increased resistance to antibiotics in bears' bacteria, affecting even those far from civilization. The study suggests that reducing antibiotic use can help decline resistance rates.
A CDC analysis of National Healthcare Safety Network data revealed a significant increase in four types of healthcare-associated infections in U.S. hospitals during the COVID-19 pandemic, with central line infections rising by 46-47% compared to pre-pandemic rates.
Researchers found a significant link between antibiotic use and an increased risk of developing colon cancer within five to ten years. The risk was highest for those taking antibiotics for over six months, with a 17% greater likelihood of colon cancer in the ascending colon compared to non-users.
Using sequential antibiotic treatment with similar but swapped antibiotics slows down bacterial adaptation to drugs, reducing cross-resistance. The study used Pseudomonas aeruginosa and found that fast switching between antibiotics constrained bacterial evolution.
Researchers analyzed oral bacteria of wild brown bears to track history of human antibiotic use and find significant decrease in antibiotic resistance after national policies were implemented. The study highlights the effectiveness of governmental policies in mitigating a major health threat on a national level.
Researchers discovered that human milk oligosaccharides can prevent GBS infections in cells and tissues, and in mouse models. The sugars may act as anti-adhesives and prebiotics to support good bacteria growth, making them a potential substitute for antibiotics.
The urgent demand for new antimicrobial agents is threatened by a lack of investment in research. Scientists propose concepts for sustainably bridging the gap between pure research and industrial implementation to create new, effective antibiotics.
A multicenter randomized trial showed acupuncture improved symptoms of moderate to severe CP/CPPS, with effects lasting over 24 weeks. Acupuncture was more effective than sham therapy in reducing symptoms and improving quality of life for men with chronic prostatitis/chronic pelvic pain syndrome.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
A study by Duke University researchers found antibiotic-resistant bacteria in the guts of lemurs living close to humans. The closer the contact, the more resistant bugs were found. Proximity to humans determined the type and abundance of resistance genes acquired.
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
The KAUST Metagenomic Analysis Platform (KMAP) enables researchers worldwide to analyze massive microbial data, eliminating the need for advanced bioinformatics skills. KMAP allows scientists to identify proteins and enzymes with potential applications in various industries, such as agriculture and pharmaceuticals.
Researchers at Washington University in St. Louis used comparative metabologenomics to study the genomes of Streptomyces bacteria and identify key factors that influence drug production. The study found that fine-tuning of specific nucleotides can control antibiotic production, offering new insights for next-generation drug discovery.
Researchers at KU Leuven found that certain antibiotics can effectively target melanoma cells' mitochondria, which are vulnerable to specific classes of antibiotics. This suggests that these antibiotics may be repurposed as anti-melanoma agents to buy time for immunotherapy.
A Rutgers study suggests that newborns at risk for Type 1 diabetes due to antibiotic exposure can have their condition reversed by receiving a maternal fecal transplant. The transplant restored key gut microorganisms and brought diabetes risk back to baseline levels.
Researchers at the University of Exeter have developed a novel method to measure bacterial acidity, which could help reduce antimicrobial resistance. The study found that certain bacteria can survive antibiotic treatment by maintaining an acidic pH, and the team is working on developing new antibiotics that target these persisters.
The study found that medications prescribed for children dropped by more than a quarter, with steep declines in infection-related medicines like antibiotics and cough-and-cold drugs. Chronic disease drug prescriptions also declined, but no change was observed in antidepressant prescriptions.
A new study found that antibiotic-resistant bacterial infections are killing children in Bangladesh, with 77% of pneumonia cases caused by gram-negative bacteria. Children with resistant infections were 17 times more likely to die than those without.
A Rutgers researcher found that penicillin alters the microbiome and gene expression in key brain areas, potentially leading to neurodevelopment problems. This study suggests reducing antibiotic use or alternatives could prevent these issues.