Articles tagged with Antibiotics
Researchers found a significant link between antibiotic use and an increased risk of developing colon cancer within five to ten years. The risk was highest for those taking antibiotics for over six months, with a 17% greater likelihood of colon cancer in the ascending colon compared to non-users.
Using sequential antibiotic treatment with similar but swapped antibiotics slows down bacterial adaptation to drugs, reducing cross-resistance. The study used Pseudomonas aeruginosa and found that fast switching between antibiotics constrained bacterial evolution.
Researchers analyzed oral bacteria of wild brown bears to track history of human antibiotic use and find significant decrease in antibiotic resistance after national policies were implemented. The study highlights the effectiveness of governmental policies in mitigating a major health threat on a national level.
Researchers discovered that human milk oligosaccharides can prevent GBS infections in cells and tissues, and in mouse models. The sugars may act as anti-adhesives and prebiotics to support good bacteria growth, making them a potential substitute for antibiotics.
The urgent demand for new antimicrobial agents is threatened by a lack of investment in research. Scientists propose concepts for sustainably bridging the gap between pure research and industrial implementation to create new, effective antibiotics.
A multicenter randomized trial showed acupuncture improved symptoms of moderate to severe CP/CPPS, with effects lasting over 24 weeks. Acupuncture was more effective than sham therapy in reducing symptoms and improving quality of life for men with chronic prostatitis/chronic pelvic pain syndrome.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
A study by Duke University researchers found antibiotic-resistant bacteria in the guts of lemurs living close to humans. The closer the contact, the more resistant bugs were found. Proximity to humans determined the type and abundance of resistance genes acquired.
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
The KAUST Metagenomic Analysis Platform (KMAP) enables researchers worldwide to analyze massive microbial data, eliminating the need for advanced bioinformatics skills. KMAP allows scientists to identify proteins and enzymes with potential applications in various industries, such as agriculture and pharmaceuticals.
Researchers at Washington University in St. Louis used comparative metabologenomics to study the genomes of Streptomyces bacteria and identify key factors that influence drug production. The study found that fine-tuning of specific nucleotides can control antibiotic production, offering new insights for next-generation drug discovery.
Researchers at KU Leuven found that certain antibiotics can effectively target melanoma cells' mitochondria, which are vulnerable to specific classes of antibiotics. This suggests that these antibiotics may be repurposed as anti-melanoma agents to buy time for immunotherapy.
A Rutgers study suggests that newborns at risk for Type 1 diabetes due to antibiotic exposure can have their condition reversed by receiving a maternal fecal transplant. The transplant restored key gut microorganisms and brought diabetes risk back to baseline levels.
Researchers at the University of Exeter have developed a novel method to measure bacterial acidity, which could help reduce antimicrobial resistance. The study found that certain bacteria can survive antibiotic treatment by maintaining an acidic pH, and the team is working on developing new antibiotics that target these persisters.
The study found that medications prescribed for children dropped by more than a quarter, with steep declines in infection-related medicines like antibiotics and cough-and-cold drugs. Chronic disease drug prescriptions also declined, but no change was observed in antidepressant prescriptions.
A new study found that antibiotic-resistant bacterial infections are killing children in Bangladesh, with 77% of pneumonia cases caused by gram-negative bacteria. Children with resistant infections were 17 times more likely to die than those without.
A Rutgers researcher found that penicillin alters the microbiome and gene expression in key brain areas, potentially leading to neurodevelopment problems. This study suggests reducing antibiotic use or alternatives could prevent these issues.
The mcr-1 gene, providing resistance to last-resort antibiotic colistin, has been detected in humans and pets worldwide since its first report in China in 2015. Research finds that household pets may be acting as reservoirs of the gene, aiding its spread in the community.
Women with recurrent urinary tract infections (UTIs) experience fear and frustration due to the risks associated with repeated antibiotic use. The study highlights the need for patient-centered research to address gaps in current UTI treatment algorithms, focusing on non-antibiotic options for prevention.
A WHO-sanctioned panel will discuss the need for more warnings before it's too late to address antimicrobial resistance. The world is facing a growing threat to modern medicine, with patients paying high prices for antibiotics due to a weak market and lack of access.
Researchers at Johns Hopkins Medicine have discovered an enzyme inhibitor, Q-VD-OPH, that boosts the immune system to fight antibiotic-resistant MRSA and other skin infections. The treatment works by reducing apoptosis of neutrophils and monocytes, leaving them in plentiful numbers to remove bacteria.
A study published at ESMO World Congress on Gastrointestinal Cancer 2021 suggests a link between antibiotic use and an increased risk of colon cancer, particularly in people under 50 years old. The research found that quinolones and sulfonamides/trimethoprim were associated with cancers in the first part of the colon.
Antibiotic use in India increased during the COVID-19 pandemic, particularly for mild and moderate cases, due to a lack of adherence to guidelines. The study highlights the need for policy changes to address antibiotic misuse and the potential consequences of drug-resistant infections.
New research from the University of Georgia reveals that 60% of cattle fecal samples contain multiple antibiotic-resistant salmonella strains, which can cause severe illness in people. CRISPR-SeroSeq technology identifies molecular signatures in bacteria's DNA, allowing for more sensitive detection of resistant strains.
Researchers developed transgenic strains of Drosophila suzukii that produce only males, using a common antibiotic as an off switch. The study found that releasing excess transgenic males into laboratory cage trials effectively suppressed female offspring.
Researchers at IU School of Medicine have made a breakthrough in treating and preventing kidney infections by utilizing the kidneys' own internal infection-fighting capabilities. The study found that intercalated cells can consume bacteria and secrete acid, offering a potential alternative to antibiotics.
Researchers have designed a miniaturized device using microplasma technology to treat middle ear infections. The treatment is effective in inactivating bacteria and may offer an alternative to antibiotics, which are often ineffective or lead to antibiotic resistance.
Researchers found that only about 30% of genes associated with aging control the body's internal clock, while the rest reflect the response to bacteria. Antibiotics extended fly lives by up to six days and altered gene activity in many hallmark aging genes.
Researchers have discovered that anaerobic fungi in herbivores' guts can produce novel antibiotic compounds, which could be used to fight disease. The fungi's ability to produce these compounds is crucial for their survival and competitiveness in the environment.
A study published in JAMA Internal Medicine found a significant decrease in respiratory virus detections during the COVID-19 pandemic. The researchers also observed a decline in antibiotic prescribing rates for respiratory tract infections, suggesting a shift towards more targeted treatment approaches.
Researchers have developed a new technique, native state mass spectrometry, to identify effective inhibitors against antibiotic-resistant bacteria. This approach analyzes the behavior of metallo-beta-lactamase inhibitors and could lead to the development of novel treatments for resistant infections.
Researchers at HKU have identified 38 authentic Ag+-binding proteins in Staphylococcus aureus, revealing silver's molecular targets and mode of action. The study shows that silver-based antimicrobials can potentiate the efficacy of antibiotics, resensitize MRSA to antibiotics, and slow down antibiotic resistance evolution.
Researchers at Duke University have demonstrated that living cells can construct semi-interpenetrating polymer networks (sIPNs) for biomedical applications. These cell-built materials exhibit medically relevant functions and could be used to release protective molecules, such as antibiotics, in a controlled manner.
Researchers developed a new framework to establish safe thresholds for antimicrobial release into the environment, addressing the global health threat of antibiotic-resistant bacteria. The framework provides guidance on risk assessment and could inform policy to reduce antimicrobial levels in water systems, helping to mitigate resistance.
Researchers at Kumamoto University developed a new analytical method to detect degraded beta-lactam antibiotics. Cysteine persulfide, a reactive sulfur species produced by bacteria, degrades and inactivates these antibiotics.
Researchers at Flinders University have discovered that fish oil fatty acids can render bacteria more susceptible to antibiotics. This discovery is vital in combating the rise of superbugs with unprecedented levels of antibiotic resistance.
A study found that travellers who returned from abroad acquired and spread destination-specific antimicrobial resistance genes in their gut microbiome. The diversity of these genes increased significantly after travel, with high-risk genes resistant to common antibiotics identified.
Researchers develop an iron-based catalyst that rapidly removes sulfadiazine antibiotic residues from water by activating H2O2 to generate free radicals. The catalyst shows high efficiency and stability, making it a potential solution for tackling micro-pollutants in water.
Researchers discovered that Ganoderic acid can increase the radiosensitivity of cancer cells, making them more susceptible to radiation therapy. This breakthrough provides new hope for cancer treatment and could lead to improved patient outcomes.
Researchers at Johns Hopkins Medicine found long-term exposure to PM2.5 increases the risk of losing one's smell by nearly twice, potentially due to airborne pollutants reaching the olfactory nerve. The study also highlights the need for better air pollution management, especially in vulnerable populations.
Researchers at the University of Texas at Austin have developed chemical probes to detect an enzyme that breaks down antibiotics, making bacteria resistant to treatment. The probes can also be used to study nutritional immunity and may help find alternative treatments for resistant bacteria.
A new study from the University of Copenhagen reveals that Danish one-year-olds carry several hundred antibiotic resistant genes in their bacterial gut flora. The presence of these genes is partly attributable to antibiotic use among mothers during pregnancy, and well-developed gut flora may reduce the incidence of resistant bacteria.
Researchers found that horned passalus beetles, known as bessbugs, have frass teeming with antibiotic and antifungal compounds produced by actinomycetes beneficial bacteria. This discovery could help speed the search for new antibiotics and improve strategies to prevent antibiotic-resistant infections.
A new study by UIC researchers shows that antibiotics designed for bacteria can also inhibit protein synthesis in human cells, potentially treating diseases like cancer and neurodegenerative disorders. The team engineered yeast ribosomes to be more bacterial-like, allowing them to respond to macrolide antibiotics.
A new study published in Nature Medicine proposes that microbes exist as networks, driving frequent flare-ups in patients with bronchiectasis. The research team analyzed over 400 respiratory samples and found negative interactions between microbes contributing to infection severity.
Researchers at UMD are exploring antimicrobials that can inhibit the pathogen on a biomolecular level, reducing the burden of Lyme disease and its symptoms like PTLDS. The grant will support preclinical testing to see whether treatment with new compounds can prevent infection.
A new study published in the New England Journal of Medicine found that surgically placing tympanostomy tubes in young children does not reduce recurrent ear infections compared to oral antibiotics. The trial also showed no increased bacterial resistance among children treated with antibiotics.
A portable, inexpensive testing platform, called PROMPT, can diagnose gonorrhea in under 15 minutes and determine its antibiotic resistance. The device has been shown to be 97% accurate in detecting the most common strain of gonorrhea and 100% accurate in determining its response to ciprofloxacin.
A portable, rapid testing platform can detect gonorrhea infections and determine antibiotic resistance in under 15 minutes. The platform's speed and low cost could combat the spread of drug-resistant strains and improve timely diagnoses for patients with gonorrhea or other STIs.
A new analysis found that third-generation fluoroquinolones are not associated with an increased risk of Achilles tendon rupture, unlike first- and second-generation antibiotics. The study suggests these newer antibiotics may present a reduced risk of tendon ruptures.
Researchers from Stanford University and the University of Chicago found that hospitals with more family physicians and midwives had lower cesarean delivery rates. Meanwhile, a study on depression treatment suggests combining psychotherapy and pharmacotherapy is more effective than separate treatments. Additionally, a new analysis on f...
A component of bacteria's cell walls, cardiolipin, may hold the key to fighting antibiotic-resistant microbes. Without it, the outer membrane becomes penetrable, making bacteria vulnerable to antibiotics.
A randomized controlled trial found that brief educational videos can reduce patients' expectations for antibiotic treatment of upper respiratory tract infections. However, the doctors' actual prescribing habits showed no significant change.
A groundbreaking study has identified IL-17 cytokine as the primary culprit behind excessive lung inflammation in TB patients. By targeting this pathway, doctors may be able to reduce disease harm and speed up patient recovery.
Researchers developed molecular tweezers to combat antibiotic-resistant bacteria by targeting biofilm. The study found that binding the tweezers to the biofilm disrupts its protective capabilities, making bacterial pathogens less virulent to the human body.
Researchers developed a microneedle patch that delivers vancomycin directly into the affected skin area, significantly reducing MRSA bacterial population. This innovative approach aims to transform the treatment of skin infections by improving quality of life for patients.
A research team at HKUST has discovered the mechanism of DNA melting and how an antibiotic called Myxopyronin inhibits this process. The study found that Myxopyronin binds to a partially closed form of the flexible clamp domain, diminishing the gate's ability to close and eventually inhibiting DNA melting.
A Swedish study of over 100,000 children found that early antibiotic exposure before birth and during the first year of life increases the risk of developing eczema. The research suggests a potential long-term consequence of antibiotic use on childhood skin health.
A large analysis of patient data suggests that delayed antibiotic prescribing is a safe and effective strategy for most patients, including those in higher risk subgroups. The study found no significant difference in symptom severity or duration between delayed and immediate antibiotics, but a slight benefit in reducing re-consultation...
Research shows that nearly half of fecal samples from wild chimpanzees contain antibiotic-resistant bacteria, highlighting the need for improved hygiene and proper antibiotic use. The study's findings will support the development of interventions to protect both human health and endangered species.