Articles tagged with Antibiotics
A new computer modeling tool integrates real-time data to help clinicians determine if a child with diarrhoea needs antibiotics. The tool shows promising results, reducing inappropriate antibiotic prescriptions by over 50%.
The researcher aims to identify common mechanisms among persister cells and their unique metabolic processes. The goal is to develop new strategies for understanding and combating bacterial persistence.
Research at Carnegie Mellon University reveals that certain bacteria can change their shape in response to antibiotic exposure, enabling them to overcome stress and resume fast growth. The study demonstrates how cell shape affects bacterial reproduction and survival, providing insight into the mechanisms of antibiotic resistance.
Research by Michigan State University finds that livestock workers are at high risk of acquiring antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The study highlights the importance of good hygiene practices and policies in minimizing the spread of livestock-associated MRSA.
Researchers have developed a method to simultaneously measure 77 antibiotics in various foods, including meat, eggs, milk, cereals, vegetables, and fruits. The new approach allows for the detection of multiple classes of antibiotics at trace amounts, which can contribute to increased antibiotic resistance and gut microbiome imbalance.
A new study found that exposure to antibiotics within the first 14 days of life is associated with reduced weight and height in boys up to age six. However, antibiotic use after neonatal period leads to higher body mass index (BMI) in both boys and girls during childhood.
Researchers found that membrane vesicles, which carry biological information between bacteria and cells, produce more info-rich bubbles in response to antibiotics. This may lead to the transmission of warning signals to neighboring cells and potentially foster antibiotic resistance.
A global analysis of antibiotic combination use reveals that 80% of commonly prescribed combinations are not recommended by the WHO. The study found that these inappropriate combinations can lead to inefficacy, toxicity, and selection for antimicrobial resistance.
A new study reveals that a single water molecule is essential for the binding of macrolide antibiotics to bacterial ribosomes, explaining why resistant bacteria are immune to these drugs. This discovery offers a promising lead in developing new antibiotics that do not require this water molecule for binding.
Researchers at Penn State have discovered a unique enzyme-catalyzed reaction in the production of thiostrepton, a potent antibiotic that can also target breast cancer cells. The breakthrough, detailed in a new Nature Chemistry study, could lead to the development of more effective human medicines.
Researchers used CRISPR/Cas9 genome editing to increase formicamycin production in Streptomyces formicae bacteria, which could lead to new antibiotics against MRSA. The over-producing strain can be used to purify enough formicamycins to study their mode of action and development as antibiotics.
A randomized clinical trial evaluated two antibiotic strategies for adults with uncomplicated acute appendicitis. The study found that one strategy resulted in lower rates of hospital discharge without surgery and recurrent appendicitis over a year.
A randomized controlled trial found no difference in infection rates and sinus symptoms between patients who received antibiotics and those who didn't after endoscopic sinus surgery. However, patients in the antibiotic group were more likely to report gastrointestinal side effects.
Researchers developed a new imaging method to track antibiotic distribution in infected tissues, revealing that some antibiotics only partially penetrate infected cells. This discovery could lead to more targeted treatments and reduced risk of antibiotic resistance.
Scientists at UC Santa Barbara have developed a new approach to addressing the challenge of antibiotic-resistant bacteria by replacing antibiotics with fluoride. The method uses a genetically engineered cell that can survive in the lab but dies when exposed to fluoride, preventing its propagation into the natural environment.
Researchers from Immanuel Kant Baltic Federal University develop novel compounds with potential as effective antibacterial drugs against drug-resistant tuberculosis pathogens. The new substances outperform existing antibiotics in sensitivity and minimal concentration needed for inhibition.
Scientists at University of Colorado Boulder develop new compound JD1 that targets Gram-negative bacteria by exploiting innate immune response, reducing survival and spread by 95%. Further studies underway to explore compounds like JD1 for commercialization.
A large study challenges the conventional practice of administering antibiotics before C-section incisions, finding them equally effective when given after clamping. This discovery may benefit newborns' developing microbiomes, potentially affecting immune system development and future health.
Researchers developed a method to reformulate gentamicin, reducing the risk of irreversible hearing loss. The new formulation, C2b, shows comparable effectiveness while minimizing toxicity.
Patients in precarious circumstances are less likely to use antibiotics appropriately, highlighting the need for sustainable development policies. Research suggests that improving living conditions can lead to better antibiotic use and tackle anti-microbial resistance globally.
The University of Huddersfield's Antimicrobial Stewardship in Wound Management course has been honoured at the Antibiotic Guardian Awards. Over 8000 healthcare professionals have completed the course with high praise, exploring antimicrobial resistance and implementing infection control measures.
Scientists have developed a potential new antibiotic for Mycobacterium abscessus, a pathogen resistant to medications with cure rates less than 50%. The compound T405 demonstrated superior potency against the bacteria, as well as an ability to prevent resistance when combined with avibactam.
A new device can detect antibiotic-resistant bacteria in just five hours by measuring naturally occurring electron transfers. The device, developed by Binghamton University researchers, has the potential to serve as an important point-of-care diagnostic tool in areas with limited resources.
Researchers at Penn State and the University of Michigan have developed an inexpensive therapy to prevent antibiotic resistance. The 'anti-antibiotic', cholestyramine, reduces fecal shedding of daptomycin-resistant bacteria by up to 80-fold, providing a potential solution to the growing problem of antimicrobial resistance.
A research team at RIKEN Center for Biosystems Dynamics Research successfully evolved Escherichia coli under antibiotic pressure, identifying mechanisms and constraints underlying drug resistance. The findings can be used to develop strategies that minimize the chance of bacteria developing resistance.
Researchers found that methacycline, a widely used tetracycline-based antibiotic, is effective at preventing brain infections and reducing neurological problems associated with Zika virus infections. The study also identified other potential candidates, including anti-inflammatory medicines and failed anti-Alzheimer's disease drugs.
A research team is working on developing new tools to guide the discovery and optimization of new antibacterial agents, addressing the growing challenge of antibiotic resistance.
A new model of CF lungs using pig lungs and synthetic mucus shows that S. aureus aggregates in mucus, rather than invading lung tissue, sparking debate over antibiotic treatment. This discovery could lead to reduced use of antibiotics and improved treatment for MRSA infection in cystic fibrosis patients.
Researchers found that PBT2 disrupts metals in polymyxin-resistant bacteria, resensitizing them to treatment and boosting survival rates in mice with sepsis. The compound may offer a solution to the growing threat of antibiotic resistance, which poses a grave danger to patients with bacterial infections.
Environmental scientists at TalTech have developed a new ozonation method to treat drinking water contaminated with pharmaceutical residues. The study compared the efficiency of ozone, ozone/hydrogen peroxide and ozone/persulfate processes in degrading sulfamethoxazole and trimethoprim, finding promising results for the O3/PS process.
Researchers found that children who received antibiotics before age 2 were more likely to develop multiple illnesses or conditions later in childhood. These include allergic rhinitis, food allergies, attention deficit hyperactivity disorder, celiac disease, and atopic dermatitis.
A study of 14,572 children found that antibiotic use during the first two years of life is associated with an increased risk of asthma, respiratory allergies, eczema, obesity and attention deficit hyperactivity disorder. Antibiotic exposure was also linked to metabolic diseases, immunological diseases and cognitive conditions.
A Harvard Medical School study found that clinicians who prescribe unnecessary antibiotics for viral infections increase the likelihood of patients seeking care for similar infections in the future. This leads to a significant increase in antibiotic prescriptions, exacerbating the problem of antibiotic resistance and unnecessary spending.
Researchers repurpose an antirheumatic gold drug, auranofin (AUR), to revive the potency of 'last-resort' antibiotics against multi-drug resistant superbugs. The combination therapy shows promising results in eradicating multidrug-resistant bacteria in animal models.
A new study demonstrates that pooling treatment recommendations from multiple prescribers using the 'wisdom of crowds' concept can improve decisions on antibiotic prescribing and reduce overuse. Using international survey data, researchers found that groups of three or more prescribers showed significant benefits in guideline compliance.
Researchers found that infant gut microbial ecosystems develop unique patterns of stability, with changes influenced by diet and antibiotic exposure. The study used genomic tools to analyze massive amounts of genetic data and identified individual strains within single species of the gut microbiome.
A study found that antibiotic use patterns and patient transfers drive the emergence of drug-resistant microbes, highlighting the need for individualized approaches to preventing resistance. The study suggests using alternative antibiotics like piperacillin-tazobactam instead of carbapenems may be necessary.
Doxycycline, an antibiotic, confers protection against sepsis by inhibiting mitochondrial protein production, reducing cell damage and promoting tissue repair. The study opens new possibilities for therapies targeting disease tolerance mechanisms to combat infections and diseases like sepsis.
Researchers at NUST MISIS have developed antibacterial nano-coatings based on boron nitride that are highly effective against microbial pathogens, including up to 99.99% efficacy against E. coli bacteria. The coatings work by releasing the antibiotic gentamicin locally, reducing the need for high doses and minimizing side effects.
Researchers developed a rapid, cost-effective method to predict lowest antibiotic concentration increasing resistance in wastewater. The SELECT assay can generate data quickly and inform decisions on safe levels of antibiotics.
Researchers found that antibiotics were not worse than surgery in terms of overall health status, allowing most people to avoid operations. Patients treated with antibiotics often returned home faster but missed less time from work and school.
The CODA trial found that antibiotics can avoid surgery for more than 70% of patients with appendicitis. However, patients with an appendicolith may face higher complications and a greater risk of needing surgery.
A new study published in the New England Journal of Medicine found that seven in ten patients who received antibiotics avoided surgery within 90 days, while four in ten with an appendicolith required surgery. Patients treated with antibiotics reported fewer workdays missed and hospital visits compared to those who underwent surgery.
The CODA Trial found that antibiotics were not worse than surgery in measuring overall health status, allowing most people to avoid operations in the short term. Patients treated with antibiotics more often returned to the emergency department but missed less time from work and school.
Researchers at the University of Tokyo have transformed an old antibiotic into stronger, safer versions using a synthetic strategy. They created over 4,000 variations of gramicidin A, identifying 10 promising future antibacterial drugs with improved specificity towards bacteria.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
Researchers developed a single-use treatment for ear infections that don't require refrigeration, addressing logistical challenges for some patients. The new treatment uses hydrogels to release an antibiotic, killing bacteria at a lower dose than traditional drops.
A major national study found that oral antibiotics are as effective as intravenous antibiotics in killing Pseudomonas aeruginosa, a common germ causing chronic lung infection in CF patients. This means CF patients with a new infection can be treated at home and saved from hospital admissions.
Researchers discovered unique bacterial profiles associated with each patient's medical condition, suggesting a personalized approach to care and antibiotic treatment. The study challenged long-held beliefs that the urinary tract is sterile.
The genome of Fleming's original Penicillium strain has been sequenced for the first time, showing that the UK and US strains use different methods to produce penicillin. The results suggest new routes for industrial production and could help inspire novel solutions to combatting antibiotic resistance.
Researchers at UCSF create customizable antibiotic molecules to evade bacterial resistance mechanisms. By redesigning existing antibiotics, they've found promising variations with activity against dozens of strains of pathogenic bacteria.
Researchers have developed magnetically propelled microbots derived from tea buds that can dislodge biofilms, release an antibiotic to kill bacteria, and clean away the debris. The T-Budbots showed promise in treating bacterial biofilms involved in hospital-acquired infections.
A new study finds growing acceptance of non-meat diets in both countries, with 44% of French and 58% of Germans willing to try cultured meat. In contrast, only 45% of German respondents identified as full meat-eaters, while 69% in France still consider themselves meat-eaters.
Researchers developed a new method to determine the effectiveness of combining two antibiotics, providing greater scope for customizing treatment. The CombiANT method allows laboratories to easily test interactions and can provide crucial information for treating bacterial infections.
A population-based cohort study found peritonsillar abscess risk low with or without antibiotics for respiratory infections. Antibiotic treatment may prevent only one case of peritonsillar abscess for every 1,000 prescriptions.
The Global Hygiene Council warns that poor home hygiene is a significant contributor to antibiotic resistance, with rates of resistance expected to exceed 40-60% in some countries by 2030. A targeted hygiene approach can help minimize the spread of infections and reduce antibiotic consumption.
Researchers found that standard CDS systems are ineffective in reducing antibiotic prescriptions in EDs. The study suggests tailoring CDS systems to the ED environment and provider needs can help reduce unnecessary antibiotic use.
A study found that antibiotics can alter the diversity and abundance of microbes in breast milk, particularly those with potential to influence growth and disease in newborns. The research suggests that antibiotic stewardship programs should focus on mothers as well as newborns.
Current understanding of safe antibiotic levels in rivers may not prevent evolution of antibiotic resistance and fully protect human health. The study suggests introducing thresholds to help combat the spread of resistant bacteria.
A joint study by University of Cologne researchers predicts the outcomes of combining certain antibiotics using mathematical models. The scientists found that interactions between antibiotics are often caused by bottlenecks in the translation cycle, allowing them to predict the effects of antibiotic combinations without trial and error.