Articles tagged with Antibiotics
Researchers at the University of Bristol used computer simulations to study how bacteria destroy antibiotics, identifying enzymes that break down carbapenems quickly and slowly. This insight will help scientists develop new antibiotics with lower resistance rates.
A systematic review and meta-analysis found that frontline health workers can accurately diagnose bacterial infections in young infants, but access to antibiotics is limited. The study suggests that improving diagnosis and antibiotic access can help reduce neonatal deaths in low- and middle-income countries.
High-resolution cryo-electron microscopy reveals the structural changes in the bacterial ribosome that result in resistance to erythromycin. The study sheds light on how bacteria acquire resistance genes and how they interact with antibiotics.
The number of antibiotics available for clinical use has declined to 96 from a peak of 113 in 2000, with the rate of withdrawals being double the rate of new introductions. Pharmaceutical companies are leaving the antibiotic space due to financial constraints and patent law, forcing research universities to step in.
Antibiotic stewardship programs in hospitals improve care for hospitalized children by reducing unnecessary antibiotics and shortening hospital stays. Children who received program recommendations were less likely to be readmitted within 30 days.
A study analyzing over 8,000 episodes of Staphylococcus aureus bloodstream infections found no significant difference in mortality risk between patients with less and more susceptible strains to the antibiotic vancomycin. The study suggests that current standards for vancomycin MIC may not need to be lowered.
Researchers at ETH Zurich have studied the molecular structure of mitoribosomes, revealing new details about how proteins are synthesized. The findings will help design antibiotics that target only bacterial ribosomes, improving their effectiveness in treating human diseases.
Research at Uppsala University finds that plasmids with genes for resistance can be enriched by very low levels of antibiotics and heavy metals, suggesting environmental contamination contributes to the problem. This highlights the need to reduce antibiotic use and minimize exposure to heavy metals.
Researchers found that doctors are more likely to prescribe antibiotics for respiratory infections later in their clinic sessions due to fatigue. The study suggests that improving the work environment could lead to better patient care outcomes.
Overuse of medical tests and treatments can cause unnecessary harm to children, says a pediatrician. The Choosing Wisely campaign has identified over 250 procedures that are considered overused or inappropriate in pediatrics.
Researchers develop a novel antibiotic technique that uses the CRISPR enzyme to target specific DNA sequences in drug-resistant microbes, while leaving harmless bacteria intact. This approach shows promise in reducing the risk of secondary infections and preventing the spread of antibiotic resistance.
Researchers found that MRSA biofilms form in joint fluid, making infections resistant to antibiotics. Pre-treatment with an enzyme can inhibit biofilm formation and increase bacterial susceptibility to antibiotics.
A study found that selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) significantly reduced antibiotic-resistant gram-negative bacteria and ICU-acquired bacteremia. Patient survival rates were similar, but SDD showed a lower incidence of ICU-acquired respiratory tract infections.
A leading expert on respiratory medicine warns of the growing concern of antibacterial resistance in treating cystic fibrosis patients. The expert recommends further research and investigation into developing new compounds that can work against bacteria to make current antibiotics more effective.
A new class of antibiotics could be developed using the anticonvulsant drug lamotrigine, which inhibits bacterial ribosome assembly. Researchers at McMaster University discovered that lamotrigine stops ribosomes from being created in bacteria, a breakthrough in tackling antibiotic resistance.
Scientists at Scripps Research Institute have devised a new vancomycin analog that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria. The new compound has two distinct mechanisms of action, making it difficult for bacteria to develop resistance.
Research finds 70% of potential unnecessary therapies represented by three specific drug combinations used to treat anaerobic infections. This overuse can contribute to antimicrobial resistance and increase healthcare costs. The study highlights the need for hospitals to improve their antimicrobial usage efforts.
A new lab test, Carba NP, has been developed to detect carbapenem-resistant Enterobacteriaceae (CRE) in just 2.5 hours, with a specificity of 100%. The test is highly sensitive and specific for detecting carbapenemase production, making it a crucial tool for preventing the spread of CRE.
A hospital-wide program in New York reduced antibiotic use by half and saved over $600,000 annually. Antibiotic stewardship also led to a significant decrease in antibiotic-resistant infections.
The Life Sciences Discovery Fund awarded nearly $750,000 in Proof of Concept grants to Washington state organizations to translate health-related technologies from the lab to the marketplace. Funding supports development of products for lupus treatment and at-home lung function monitoring.
Researchers identified a unique interaction between cyclic-di-GMP and protein BldD, which controls the developmental switch in Streptomyces, turning it into an antibiotic factory. The small molecule assembles into a molecular glue, connecting two copies of BldD to regulate development.
Rice University scientists have successfully synthesized a newly discovered natural antibiotic, viridicatumtoxin B, which shows potent activity against Gram-positive bacteria. The simplified synthesis of this compound may pave the way for developing more effective antibiotics against superbugs.
A nationwide population-based study in Sweden found that six percent of men filled a prescription for antibiotics within 30 days after having a prostate biopsy, with a twofold increase in hospital admissions over five years. Men with prior infections or significant comorbidities were at highest risk.
The study found that gram-positive bacteria, including staph and strep infections, accounted for 95 percent of endophthalmitis cases. The findings suggest better treatment with targeted antibiotics, but also highlight increasing resistance to certain antibiotics.
A study found that clarithromycin, a widely used antibiotic, is associated with an increased risk of heart deaths in people over 40-74 years old. The absolute risk difference was 37 cardiac deaths per 1 million courses with clarithromycin.
Researchers found that antibiotics can alter the gut's bacterial ecosystem, increasing susceptibility to diseases like hypersensitivity pneumonitis. The study suggests that probiotics could be used to boost helpful bacteria and prevent disease.
Researchers found that a free fatty acid compound is equally effective as antibiotics in treating certain catheter-related bloodstream infections. The study suggests that these compounds could provide an alternative treatment option for preventing and treating intravenous catheter infections.
Long antibiotic treatments are ineffective against slowly growing bacteria that persist in tissues, leading to ongoing disease. Slowly growing pathogens dominate treatment, posing a risk for relapse despite effective initial therapy.
Research reveals that altering the intestinal microbiota during infancy can have lasting metabolic consequences, increasing the risk of obesity and diabetes in adulthood. Disrupting beneficial gut bacteria with antibiotics during critical developmental windows may lead to obesity and metabolic problems.
A new study suggests that early antibiotic exposure disrupts the gut microbiome, permanently altering metabolism in mice. Researchers found that mice exposed to low-dose penicillin during pregnancy or nursing were more susceptible to obesity and metabolic abnormalities than those exposed later in life.
A highly virulent, multidrug-resistant form of Pseudomonas aeruginosa has been discovered in patient samples in Ohio. The strain contains a gene for a drug-resistant enzyme called metallo beta-lactamase, making it resistant to multiple antibiotics.
A Canadian hospital reduced cardiac surgical site infections (SSIs) by 77% through a comprehensive safety program. The hospital implemented best practices in prophylactic antibiotic use, wound care, and patient warming to lower the SSI rate from 7% to 1.6%.
A new study published in The Lancet Infectious Diseases found that less than 1% of UK public and charitable funding was allocated to bacteriology projects, with only around 0.7% dedicated to antibiotic research. This inadequate funding poses a significant threat to tackling the growing crisis of antibiotic resistance.
A study published in Journal of Pediatric Urology found that for most children with antenatal hydronephrosis, continuous antibiotics are not needed. The research suggests that prophylactic antibiotics are only necessary for those with severe conditions, reducing the risk of urinary tract infections.
A study of 6,800 outpatients found antiviral therapy was given to only 19% of those at high risk for complications, while antibiotics were prescribed to 30%. The findings suggest a need for increased education on appropriate use in outpatient settings.
Despite limited evidence, antibiotics are still widely prescribed to terminal hospice patients, with 27% continuing use in final week of life. This raises concerns about unnecessary side effects, adverse events, and antibiotic resistance.
Researchers develop new technique to quickly uncover novel products produced by bacteria, reducing screening time from thousands to just a few dozen. The method uses genomics and mass spectrometry to detect reactive compounds, enabling the discovery of new antibiotics and anticancer drugs.
Researchers found that low-dose antibiotics can strengthen bacterial biofilms, leading to chronic lung, sinus, and ear infections in children. The study suggests developing routine screening methods to test the effects of antibiotics on biofilms.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched a Phase I clinical trial of CRS3123, an investigational oral antibiotic aimed at treating Clostridium difficile infection. The study aims to evaluate the safety and tolerability of the medication in healthy adults.
A study published in JAMA found that patients who underwent gall bladder removal without postoperative antibiotic treatment did not experience a higher incidence of infections compared to those who received antibiotics. The lack of antibiotic treatment was associated with similar length of hospital stay and readmission rates.
A recent study published in PLOS Medicine found that 50 pregnant women develop life-threatening maternal sepsis, often progressing rapidly, while antibiotics do not prevent progression to severe sepsis. The authors recommend closer monitoring of symptoms and follow-up for pregnant or recently pregnant women with suspected infections.
Researchers found that a low-dose gentamicin/citrate solution reduced mortality by 68% and bloodstream infections by 73% compared to heparin. Bloodstream infections are a leading cause of hospitalization and death in hemodialysis patients.
Scientists have discovered that bacteria can develop a biological timer to survive under antibiotic exposure, adapting their dormant period to match the treatment duration. This breakthrough has significant implications for slowing the evolution of antibiotic resistance.
Researchers at Oregon State University have successfully developed a new compound with improved antibacterial activity against multi-drug resistant strains of tuberculosis. The findings offer an important new avenue for treatment of the disease, which is responsible for over 1 million deaths annually.
Researchers at McMaster University have discovered a fungus-derived molecule called AMA that can stop the spread of the deadly antibiotic-resistant gene NDM-1. Testing revealed that the molecule rescues carbapenem antibiotics' activity, providing a new way to combat superbugs.
Researchers used experimental evolution to study E. coli populations under strong and mild antibiotic selection conditions. They found higher cross-resistance in strongly selected strains with increased pathway-specific mutations.
Scientists at the University at Buffalo are developing novel dosing regimens for polymyxin antibiotics to combat 'superbugs' like Acinetobacter baumannii and Pseudomonas aeruginosa. The research aims to maximize antibacterial activity while minimizing resistance and toxicity.
A study published in mBio found that fecal transplants partially restored a diverse community of healthy gut bacteria to recipients, reducing the amount of infectious Proteobacteria and increasing Firmicutes and Bacteroidetes bacteria. The transplants also improved metabolic pathways, including those involved in stress response.
Researchers have discovered that populating GI tracts with Bacteroides species producing beta-lactamase enzyme protects good commensal bacteria from antibiotics. This finding suggests a potential new strategy for preserving the gut microbiome during antibiotic treatment.
Scientists at Max Planck Institute have successfully generated new plant species through grafting, allowing for the transfer of entire genetic material between two species. The resulting plants exhibit improved growth rates and increased fitness compared to their parent species.
A new antibiotic, oritavancin, has shown effectiveness in treating methicillin-resistant Staphylococcus aureus (MRSA) and other skin infections with a single dose. The study found that the prolonged activity of oritavancin allows for a single-dose treatment, which could potentially prevent hospitalizations and reduce healthcare costs.
A study of nearly 65,000 older patients with pneumonia found that azithromycin reduced mortality by 17.4%, while increasing the risk of heart attacks by 5.1%. The treatment also had a slight increase in cardiac arrhythmias and heart failure
A study published in Clinical Infectious Diseases found that nearly seven million Americans seek medical attention for sore throats each year, with one in 10 cases being strep throat. The researchers concluded that performing a laboratory culture can help doctors and patients avoid both under-treatment and over-treatment of sore throats.
A small molecule peptide destroys biofilms and prevents their formation in various bacteria, including those resistant to antibiotics. The discovery offers a promising strategy to target bacterial biofilms and combat antibiotic-resistant infections.
Growing resistance to antibiotics demands a united global response, with experts calling for an independent body to oversee surveillance and set evidence-based targets. The world faces a future where simple infections become deadly diseases, with treatment relying on just one or two drugs.
The OU research team will investigate three specific antibiotic resistant pathogens, focusing on their structural components and physico-chemical properties. The goal is to develop a realistic predictive model that facilitates the design of effective antibiotics capable of penetrating the cell wall of these bacteria.
A new strategy to quickly screen whole libraries of compounds has been developed to find elicitors that turn on silent gene clusters. Two silent gene clusters were successfully activated, leading to the discovery of a new metabolite.
A recent study found that antibiotics were prescribed at a high rate for acute bronchitis in the US between 1996 and 2010, contrary to guidelines. The rate of antibiotic prescribing increased significantly during this time period, from 60-80% in the early 2000s to 71% by 2010.
Researchers have developed a class of chemical agents that targets new biological receptors in bacteria, changing their multicellular behaviors. These disaccharide derivatives mimic natural rhamnolipids and have potential applications in treating bacterial infections and inhibiting horizontal gene transfer.
A study found that C-section deliveries and early antibiotic treatment may alter a child's microbiota, increasing the risk of developing eosinophilic esophagitis. The condition is marked by irritation, inflammation, and constriction of the esophagus, and its symptoms mimic garden-variety gastritis.